| Project/Area Number |
08671684
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nara Medical University |
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Principal Investigator |
INADA Yuji Nara Medical University, Depertment of Emergency and Critical Care Medicine, Lecturer, 救急医学教室, 講師 (90254515)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUI Akihiro Nara Medical University, Depertment of Orthopedic Surgery, Assistant professor, 整形外科, 助教授 (90145847)
村田 景一 奈良県立医科大学, 医学部, 医員
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | Venous flap / Pedicled flap / Nerve / Venous Hap / areolar tissue / venous flap |
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| Research Abstract |
we evaluated experimentally the feasibility of transferring a pedicled venous flap with perivenous areolar tissue into an ectopic site, and investigated the role of each vein, the perivenous areolar tissue and nerve in the viability of pedicle venous flaps. Five groups of flaps were created Group 1 : (N=11) containing perivenous areolar tissue and a draining vein ; Group 2 : (N=10) perivenous areolar tissue, a draining vein and nerve ; Group 3 : (N=1O) only perivenous areolar tissue ; Group 4 : (N=6) perivenous areolar tissue and nerve ; Group 5 : (N=6) only draining vein.
Macroscopic, angiographic and histological assessments were performed 14 days after transfer. Total survival area including superficial necrosis of Group 1,2,3,4 and 5 were 52.7%, 825%, 0%, 225% and 0% respectively. There were significant differences in mean survival area and mean total survival area including superficial necrosis between Group 1 and Group 2 (p(]SY.di-substituted right.[)O.O5). In contrast, all flaps in Group 3 and Group 5 became necrotic. These data suggest that a preserved vein is the necessary condition and additional arterial flow through the preserved nerve and a small vascular network within the areolar tissue may play an important role in flap survival.
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