Dura mater against invasive ossification by grafted periosteum
| Project/Area Number |
08671703
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kurume University |
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Principal Investigator |
NAGATA Kensei Medical department, Kurume University Professor, 医学部, 教授 (50140687)
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| Co-Investigator(Kenkyū-buntansha) |
IMOTO Hiroki Medical department, Kurume University Assistant, 医学部, 助手 (20289466)
SONODA Kyousuke Medical department, Kurume University Assistant, 医学部, 助手 (00289464)
有吉 護 久留米大学, 医学部, 講師 (50184297)
石橋 和順 久留米大学, 医学部, 助手 (20193352)
大橋 輝明 久留米大学, 医学部, 講師 (30167308)
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | dura mater / periosteum / mechanism of ossification / pretect of ossification |
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| Research Abstract |
The dura mater plays an important role in the protection of the spinal cord. In patients with ossification in the spinal ligaments, the ossification is occasionally reported to extend to the dura mater, which may lead to serious myelopathy. Previous studies have shown that the postoperative prognosis is poor when ossification in the spinal ligaments involves the dura mater. To investi gate whether the periosteum could also cause ossification in the dura mater, a study was per formed in which the periosteum of the radius was transplanted to the dura mater in rabbits. Forty rabbits each weighing 1.5-2.0kg were used as the experimental animal, and were divided into a control group and a grafted periosteum group. The former consisted of 20 rabbits that underwent only laminectomy at L5/6, while the latter consisted of 20 rabbits in which the periosteum was removed from the radius, and was grafted onto the dura mater at L5/6. We resulted that, in the control group, all animals showed an inflammatory reaction and scar tissue at the operation site around the dorsal aspect of the dura mater at L5/6, but showed no degeneration and no ossification. The dura mater remained normal, without any histological change. In the periosteum graft group, new bone formation induced by the periosteum graft was apparent around the dorsal site of the dura mater at L5/6 in all 20 animals. The dura mater was affected by the invasive ossification in the process of producing new bone formation due to the grafted periosteum. The dura mater in eleven (55%) of the 20 animals did not keep normal organization, and showed mild but morpho logically diverse changes. Such degeneration included edema, thinning, separation and atrophy in the collagen bundles of the dura mater. However, none (0%) of the animals showed ossification in the dura mater.
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Report
(4 results)
Research Products
(12 results)
