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Evaliation of Intraoperative Deliberate Mild Hypothermia during Neurosurgery

Research Project

Project/Area Number 08671763
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionNara Medical University

Principal Investigator

KAWAGUCHI Masahiko  Nara Medical University Department of Anesthesiology Instructor, 医学部, 助手 (60275328)

Co-Investigator(Kenkyū-buntansha) FURUYA Hitosh  Nara Medical University Department of Anesthesiology Professor, 医学部, 教授 (70183598)
坂本 尚典  奈良県立医科大学, 医学部, 助手 (40275334)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsHypothermia / Neurosurgery / Anesthesia / Temperature / Shivering / 脳外科手術 / 脳循環
Research Abstract

Investigations in animals have demonstrated that mild degree of hypothermia (2-4゚C temperature reduction) are associated with substantial decrease in histologic damage in models of both global and focal cerebral ischemia. Therefore, we induced deliberate mild hypothermia in 130 patients who underwent intracranial operation using a water blanket and a convective device blanket. Anesthesia was maintained with nitrous oxide in oxygen, fentanyl and sevoflurane. The lowest temperature measured at the tympanic membrane during mild hypothermia was adjusted to 34.5゚C.Cooling and rewarming occurred at a rate of 1.3(]SY.+-。[)0.8゚C/h and 0.8(]SY.+-。[)0.3゚C/h, respectively. The cooling rate was mainly related to the weight to surface area ratio. Shivering was observed postoperatively in 30% and the occurrence of shivering was associated with age, weight, and core and peripheral temperature at the emergence from anesthesia. Intraoperative infusiion of prostaglandin E1 at a dose of 0.02 and 0.05mug/kg/h did not affect the changes in core temperature, although 0.05mug/kg/h of prostaglandin E1 increased the rewarming rate of rectal temperature. Intraoperative mild hypothermia did not affect the occurrence of postoperative wound infection and duration until the discharge compared with normothermia.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 川口 昌彦、坂本 尚典、他: "脳外科手術に対する術中軽度低体温療法における体温調節法および安全性の検討" 臨床麻酔. 20・11. 1617-1620 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 川口 昌彦、坂本 尚典、他: "脳外科手術に対する軽度低体温療法における冷却速度に関する検討" 循環制御. 18・4. 535-540 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 川口 昌彦、坂本 尚典、他: "脳外科手術に対する術中軽度低体温療法におけるシバリング発生因子の検討" 麻酔. 47・3. 262-268 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Masahiko Kawaguchi, Takanori Sakamoto, et al.: "The feasibility and safely of deliberate mild hypothermia during neurosurgery" J Clin Anesth (Jpn). 20. 1617-1620 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Masahiko Kawaguchi, Takanori Sakamoto, et al.: "Analysis of cooling rate during deliberate mild hypothermia for neurosurgery" Circ Cont. 18. 535-540 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Masahiko Kawaguchi, Takanori Sakamoto, et al.: "Analysis of postoperative shivering following the deliberate mild hypothermia during neurosurgery" Jpn J Anesth. 47. 262-268 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 川口昌彦、坂本尚典、他: "脳外科手術に対する術中軽度低体温療法における体温調節法および安全性の検討" 臨床麻酔. 20・11. 1617-1620 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 川口昌彦、坂本尚典、他: "脳外科手術に対する軽度低体温療法における冷却速度に関する検討" 循環制御. 18・4. 535-540 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 川口昌彦、坂本尚典、他: "脳外科手術に対する術中軽度低体温療法におけるシバリング発生因子の検討" 麻酔. 47. 262-268 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 川口昌彦: "脳外科手術に対する術中軽度低体温療法における体温調節法および安全性の検討" 臨床麻酔. 20・11. 1617-1620 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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