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Optimization of Drug Dosing Scheme Based on Bioimpedance Analysis

Research Project

Project/Area Number 08671770
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionKEIO UNIVERSITY

Principal Investigator

TSUZAKI Koichi  Keio University, Anesthesiology, Assistant Professor, 医学部, 講師 (90138107)

Co-Investigator(Kenkyū-buntansha) TATARA Tsuneo  Keio University, Anesthesiology, Assistant, 医学部, 助手 (30207039)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
Keywordsbioimpedance analysis / pharmacokinetics / body fluid composition / vecuronium / propofol
Research Abstract

This study was originally intended to clarify the relationships between pharmacokinteic parameters of intravenous drugs and the body fluid composition estimated from bioimpedance analysis (BIA). However, conventional (whole body) BIA may not adequately reflect the distribution of extracellular fluid, because such fluid distribution may be quite uneven among different body parts. In this regard, we have shown that segmental BLA from each body segments (arm, trunk and leg) is superior to whole body BIA which tends to underestimate the volume of extracellular fluid. On the other hand, inflammatory changes and edema due to perioperative tissue injury may have significant influences on both body fluid distribution and the fate of drug administered intravenously. Thus, we further evaluated the perioperative changes in BIA with the newly derived theoretical model based on the electrical property of colloid suspension. Although we found good correlation between BIA and the model, we still need the credibility of the model in utilizing those parameters to establish an optimized drug dosing scheme. Our goal is to extract clinically useful predictors for planning dosing strategy from BIA and further theoretical refinement is still remained to be established.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 多田羅恒雄: "多周波数生体インピーダンス法による重症患者の体液量モニタリング" ICUとCCU. 21・9. 789-797 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tsuneo Tatara: "Segmental bioelectrical impedance analysis improves the prediction of extracellular water volume changes during abdominal surgery" Crit Care Med. 26・3. 470-476 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tsuneo Tatara and Koichi Tsuzaki: "Multifrequency bioelectrical impedance analysis for boby fluid volume monitoring in critically ill patients" ICU & CCU. 21-9. 789-797 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tsuneo Tatara and Koichi Tsuzaki: "Segmental bioelectrical impedance analysis improves the prediction for extracellular water volume changes during abdominal surgery" Crit Care Med. 26-3. 470-476 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tsuneo Tatara: "Segmental bioelectrical impedance analysis improves the prediction of extracellular water volume changes during abdominal surgery" Crit Care Med. 26・3. 470-476 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 多田羅恒雄: "多周波生体インピーダンス法による重症患者の体液量モニタリング" ICUとCCU. 21・9. 789-797 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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