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Fever as a defense system of the body to surgical stress-Its physiological investigation and relationship to anesthesia

Research Project

Project/Area Number 08671772
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionTokyo Women's Medical University

Principal Investigator

OZAKI Makoto  Tokyo Women's Medical University, Anesthesiology, Associate Professor, 医学部, 助教授 (30160849)

Co-Investigator(Kenkyū-buntansha) ATARASHI Kenji  Toyko Women's Medical University, Anesthesiology, Clinical Instructor, 医学部, 助手 (60184181)
NEGISHI Chiharu  Toyko Women's Medical University, Anesthesiology, Clinical Instructor, 医学部, 助手 (40189361)
OZAKI Kyoko  Toyko Women's Medical University, Anesthesiology, Clinical Instructor, 医学部, 助手 (00162561)
MORIOKA Nobutada  Toyko Women's Medical University, Anesthesiology, Clinical Instructor (60256518)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsAnesthesia / Cytokines / Fever / Pyrogen / Temperature / Hyperthermia / Surgical Stress / IL-1(α,β) / IL-6 / TNFα / INFα / MIP-1(α,β)
Research Abstract

No matter how strictly the surgeons perform operation aseptically, 90% of the 1^<st> post-operative-day patients have significant fever. We found these post-operative fever had tight relationship with cytokines such as IL-1 (alpha, beta), IL-6, TNFalpha, INFalpha, MIP-1(alpha, beta). Surgical stress also provoke the release of various types of cytokines, especially IL-6 is known as sensitive cytokines to intensity of surgical stress and depth of anesthesia.
In this study, we investigated the interactions between fever and plasma cytokines changes during surgery and post-operatively. We also studied volunteers, each was given an intravenous injection of 50,000 IU/kg of interleukin-2 followed 2 hours later by 100,000 IU/kg. Volunteers were assigned randomly to three doses of desflurane to induce anesthesia : (1) 0.0 minimum alveolar concentration (MAC ; control), (2) 0.6 MAC and (3) 1.0 MAC.Desflurane-induced anesthesia produced a dose-dependent decrease in integrated and peak core temperatures after administration for pyrogen, with 1.0 MAC essentially obliterating fever. Anesthetic-induced inhibition of the pyrogenic response is therefore one reason that fever is an inconsistent clinical response to inflammation during surgery.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 尾崎 眞: "麻酔・集中治療領域におけるさまざまな体温研究について" 麻酔. 45・7. 804-812 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Chiharu Negishi et al: "Desflurane Pednces the Febrile Responses to Administration of Interleukin-2" Anesthesiology. 88・5. 1162-1169 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Chiharu Negishi et al: "Paralysis Only Silightly Pednces the Febrile Response to Interleukin-2 during Isoflurane Anesthesia" Anesthesiology. 89・3. 648-656 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 尾崎 眞: "麻酔・集中治療領域におけるさまざまな体温研究について" 麻酔. 45・7. 804-812 (1996)

    • Related Report
      1998 Annual Research Report
  • [Publications] Chiharu Negishi et al: "Desflurane Reduces the Febrile Responses to Administration of Interleukin-2" Anesthesiology. 88・5. 1162-1169 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Chiharu Negishi etal: "Paralysis Only Slightly Reduces the Febrile Response to Interleukin-2 during Isoflurane Anesthesia" Anesthesiology. 89・3. 648-656 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Rainer Lenharolt, Makoto Ozaki: "Paralysis only slightly Reduces the Febrile Response to Interleukin-2 During Isoflurane Anesthesia" Anesthesiology. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 尾崎 眞: "麻酔と体温管理 in 麻酔科学レビュー'97" 総合医学社・東京, 214 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 尾崎 眞: "麻酔・集中治療領域におけるさまざまな体温研究について" 麻酔. 45. 804-812 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 新 健治,尾崎 眞: "セボフルレン,イソフルレンが術中体温と体温調節性末梢血管収縮域値に与える作用" 麻酔. 45. 818-823 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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