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Why dose calcium channel blocker facilitate the antinociception in the spinal cord.

Research Project

Project/Area Number 08671775
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionKINKI UNIVERSITY SCHOOL OF MEDICINE

Principal Investigator

WAKITA Katsutoshi  Kinki University School of Medicine・Department of Anesthsiology, assistant stuff, 医学部・附属病院, 助手 (80258053)

Co-Investigator(Kenkyū-buntansha) TUCHIYA Norio  Kinki University School of Medicine・Department of Anesthsiology, assistant stuff, 医学部・附属病院, 助手 (80288943)
OKUDA Takahiko  Kinki University School of Medicine・Department of Anesthsiology, assistant profe, 医学部・附属病院, 助教授 (00152421)
初岡 和樹  近畿大学, 医学部・附属病院, 助手 (00258055)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥600,000 (Direct Cost: ¥600,000)
Keywordsopioid / alpha 2agonist / Ca++ channel blocker / antinociception / Ca^<++>channel blocker / K^+channel blocker / カルシウム・チャンネル・ブロッカー / 脊髄 / カリウム・チャンネル・ブロッカー / α2アゴニスト / コリン作働薬
Research Abstract

We have concluded that opioid, alpha 2agonist and benzocliazepinehave the suppersive effect of the transmission of pain in the spinal cad.
Now our aim of this study was the relationship of ion-channel with the antinociception of these drugs. We clearedthat in behavior test Ca++ channel blocker facilitates the antinociception of opioid (fenranyl) and alpha 2agonist(clonidine). Thereforewe concludedthat ATP-sensitive K^+channel blocker facilitates the antinociception of opioid (fentanyl) and alpha 2agonist (clonidine), However Ca++dependent K^+channel blocker facilitates that of alpha 2agonist (clonidine) but not that of opioid (fentanyl). Thereforewe can suggest that the antinociception of opioid and alpha 2agonist included the relationship of Ca++ channel (especially, N-type) and K^+ channel, but there is the differenceof relationship with K^+ channel between opioid and alpha 2agonis.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 初岡和樹: "ラット脊髄におけるクロニジンの抗侵害刺激作用" 日本歯科麻酔学会雑誌. 27. 39-47 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 初岡和樹: "ラット脊髄におけるクロニジンの抗侵害刺激作用" 日本歯科麻酔学会雑誌. 27巻1号. 39-47 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 奥田隆彦: "Enhancement of clonidine in doced antinociceplion by diltiazem in spinalcond of rats." Pain Reserch. 12・1. 9-14 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 奥田隆彦: "Enhaicement of clonidine antincciceptive effect by dilfiazem in spin/con/of 解読負荷" Pain Research.(in press).

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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