| Project/Area Number |
08671784
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | TAZUKE KOFOKAI MEDICAL RESEARCH INSTITUTE |
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Principal Investigator |
HARA Yasufumi Tazuke Kofukai Medical Risearch Institute Department III Oncology., 医学研究所・第3研究部, 主任研究員 (80281608)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Kumi Kiyoto University School of Medicine Department of Metabolism and clinixal Nutri, 医学研究科, 助教授 (30198204)
HIRAKATA Hideo Kiyoto University School of Medicine Department of Metabolism and clinixal Nutri, 医学研究科, 助手 (70271509)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Platelet / Propofofol / Sevoflurance / Halothane / cyclooxygenase / Inositol tri-phosphate / thromboxane / セボフルラン / イノシトール3リン酸 / トロンポキサン / 静脈麻酔 / アラキドン酸 / プロスタグランジン |
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| Research Abstract |
Dr.Hirakata, a co-worker of this sutdy, examined the effects of volatile anesthetics on platelet aggregation as the first step of the study. He revealed that halothane and sevoflurane, but not isoflurane, suppressed cyclooxygenase activity to inhibit platelet aggregation (Anesthesiology 85 : 1147-53,1996 and 87 : 1016-7,1997). He also examined the effects of volatile anesthetics on platelet aggregation in vivo and showed that platelet aggregation was impaired during anesthesia with sevoflurane but not with isoflurane (Can J Anaesth 44 : 1157-61,1997).
Dr. Hirakata, a co-worker of this study, showed that propofol had both enhancing and suppressive effects on platelet aggregation. He also revealed and reported that the mechanism of the suppressive effects of propofol on platelet aggregation was the suppression of cyclooxygenase activity (annual meeting of Japan Society of Anesthesiology, 1998). Finally, he confirmed that propofol increased inositol tri-phosphate in stimulated platelets to enhance platelet aggregation. He is submitting a scientific paper to Anesthesiology (the journal of American Society of Anesthesiologists) to publish above findings.
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