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Angiogenesis of human prostate cancer

Research Project

Project/Area Number 08671815
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionShimane Medical University

Principal Investigator

IGAWA Mikio  Professor of Urology, Shimane Medical University, 医学部, 教授 (30159587)

Co-Investigator(Kenkyū-buntansha) SHIRAKAWA Hiroki  Lecturer of Urology, Shimane Medical University, 医学部, 助手 (60263539)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordsprostate cancer / angiogenesis / bFGF / VEGF / color doppler
Research Abstract

We assessed the expression of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) in human prostate cancer cell line PC-3. The expression of b FGF and VEGF increased by the growth stimulation of serum. The growth of PC-3 cells was suppressed by anti-bFGF neutralizing antibody. Also, we investigated the association of transrectal color doppler signal detection in prostate cancer with biologic behavior as assessed by tumor Gleason grade and tumor stage. Histological examination of radical prostatectomy specimens revealed a close relationship between increased flow signals and tumor grade. Increased color doppler flow was evaluated by immunohistochemical study and high color doppler flow was associated with greater numbers of vessels. We may conclude that the angiogenesis is closely related to biologic behavior of prostate cancer.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Igawa M: "Immunohistochemical evaluation of proliferating cell nuclear antigen, prostate-specific antigen and α1-antichymotrypsin in human prostate cancer." British Journal of Urology. 77. 107-112 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Igawa M: "Association of nm23 protein levels in human prostates with proliferating cell nuclear antigen expression at autopsy." European Urology. 30. 383-387 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shiina H: "immunohistochemical analysis of estramustine binding protein with particular reference to proliferative activity in human prostatic carcinoma." Prostate. 32. 49-58 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Moriyama-Gonda N: "Heat-induced membrane damage combined with adriamycin on prostate carcinoma PC-3 cells : correlation of cytotoxicity, permeability and p-glycoprotein or metallothionein expression." British Journal of Urology. 82. 552-559 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary

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Published: 1996-04-01   Modified: 2016-04-21  

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