| Project/Area Number |
08671845
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Tokai University |
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Principal Investigator |
KITAMURA Makoto (1997-1998) Tokai University, Internal Medicine, Ass.Professor, 医学部, 講師 (00214817)
飛田 美穂 (1996) 東海大学, 医学部, 助教授 (20147169)
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| Co-Investigator(Kenkyū-buntansha) |
北村 真 東海大学, 医学部, 講師 (00214817)
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1998: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | renal failure / hemofiltration / recycle filtration / blood purification / recycle filtration / fluid purification / conventional membranes / endotoxin contamination / tap water |
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| Research Abstract |
A new recycle filtration (RF) system for blood purification was developed. This new system is as safe as a conventional dialysis against endotoxin back contamination form the dialysate ; does not require substitution fluid ; and can be applied to hemofiltration, continuous bemofiltration, hemodiafiltration and continuous hemodiafiltration therapies. An in vitro experiment using drain fiuid from hemofiltration showed that an increased recycle fluid flow is accompanied by increased urea nitrogen (UN) and creatinine (Cr) clearances in the dialysis unit and increased beta- 2- microglobulin (beta- MG) clearance in the filtration unit, and a lowered recycle rate. No significant decrease in beta- MG clearance with time in the dialysis unit was observed during 24 hours of continuous recycle. In an in vitro experiment using bovine blood and a polysulfone membrane in the first filter, endotoxin was not detected in the recycled fluid even with a dialysate reconstituted by tap water. At a blood flow of 210 ml/min and recycle fluid flow of 80 mVmin, the respective clearauce of UN,Cr and beta 2- MG was 80.9 * 1.0, 72.0 * 2.5 and 40.1* 0.9 mVmin. These results suggest that the RF system may be used in maintenance dialysis .Clinical efficiency of RFS were studied. Efficiency of reduction rate in urea UN, Cr, uric acid(UA), phosphate(IP), beta-MG with RF were no less than that of hemofiltration (HF) method. The efficiency was completely dose depending on regeneration fluid volume up to 20 litter. There was no significant change in blood analysis with RF.No clinical adverse effect was recognized of patients during PIP treatment. RF system was considered to be a useful hemopurification therapy for chronic and acute renal failure and also for treatment in intensive care unit.
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