| Project/Area Number |
08671854
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
SAGAWA Tadashi Medical Hospital., Hokkaido Univ., Lecturer, 医学部・附属病院, 講師 (20170623)
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| Co-Investigator(Kenkyū-buntansha) |
FURUTA Itsuko Fac.of Med., Hokkaido Univ., Instructor, 医学部, 助手 (70238682)
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | CERVICAL MUCUS / CYTOKINE / PREMATURE LABOR / PRETERM DELIVERY / PRETERM RUPTURE OF MEMBRANES / GRANULOCYTE ELASTASE / 顕粒球エラスターゼ / 顆粒球エラスターゼ / インターロイキン-1α / インターロイキン-1β / インターロイキン-6 / インターロイキン-8 / 細菌性腟症 / 頚管炎 |
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| Research Abstract |
We assayed interleukin-1alpha , interleukin-1beta, interleukin-6 and interleukin-8 in specimens of cervical mucus to assess defense mechanisms against infection in the cervical canal during pregnancy. Two hundred thirty-nine pregnant women who attended the obstetrics outpatient clinic in our hospital were included as subjects. Cervical mucus was collected with a newly developed collection swab, and cytokines and granulocyte elastase in the samples of cervical mucus were quantified using enzyme immunoassay kits. Interleukin-1alpha , interleukin-1beta and interleukin-8 levels significantly elevated as the degree of cervical inflammation increased. High concentrations of interleukin-1alpha (75.36 * 19.93 pg/mL), interleukin-1beta (1005.29 * 238.75 pg/mL) and interleukin-8 (4822.4 * 633.2 pg/mL) were found in the specimens from the group with severe inflammation of the cervical canal. These cytokines may be involved in defense mechanisms against ascending infection from the vagina and influence the clinical course of pregnancy.
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