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CYTOKINE CONCENTRATIONS IN PREGNANT WOMEN AND RELATION BETWEEN CYTOKINE AND PRETERM DELIVERY

Research Project

Project/Area Number 08671854
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

SAGAWA Tadashi  Medical Hospital., Hokkaido Univ., Lecturer, 医学部・附属病院, 講師 (20170623)

Co-Investigator(Kenkyū-buntansha) FURUTA Itsuko  Fac.of Med., Hokkaido Univ., Instructor, 医学部, 助手 (70238682)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
KeywordsCERVICAL MUCUS / CYTOKINE / PREMATURE LABOR / PRETERM DELIVERY / PRETERM RUPTURE OF MEMBRANES / GRANULOCYTE ELASTASE / 顕粒球エラスターゼ / 顆粒球エラスターゼ / インターロイキン-1α / インターロイキン-1β / インターロイキン-6 / インターロイキン-8 / 細菌性腟症 / 頚管炎
Research Abstract

We assayed interleukin-1alpha , interleukin-1beta, interleukin-6 and interleukin-8 in specimens of cervical mucus to assess defense mechanisms against infection in the cervical canal during pregnancy. Two hundred thirty-nine pregnant women who attended the obstetrics outpatient clinic in our hospital were included as subjects. Cervical mucus was collected with a newly developed collection swab, and cytokines and granulocyte elastase in the samples of cervical mucus were quantified using enzyme immunoassay kits. Interleukin-1alpha , interleukin-1beta and interleukin-8 levels significantly elevated as the degree of cervical inflammation increased. High concentrations of interleukin-1alpha (75.36 * 19.93 pg/mL), interleukin-1beta (1005.29 * 238.75 pg/mL) and interleukin-8 (4822.4 * 633.2 pg/mL) were found in the specimens from the group with severe inflammation of the cervical canal. These cytokines may be involved in defense mechanisms against ascending infection from the vagina and influence the clinical course of pregnancy.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] T.Sagawa: "Cytokines concentrations in the cervical mucus of pregnant women. J.Obstet." Gynaecol.22. 517-522 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] S.Begum: "Screening for bacterial vaginosis and cervicitis aimed at preventing premature deliver" J.Obstct.Gynaecol.23. 103-110 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] S.Fujimoto: "Recent advance in diagnosis of preterm premature rupture of the membranes" Hokkaido University School of Medicine, 77 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Sagawa: "Cytokines concentrations in the cervical mucus of pregnant women.J.Obstet" Gynaecol.Res.22. 517-522 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] S.Begum: "Screening for bacterial vaginosis and cervicitis aimed at preventing premature delivery" J.Obstet.Gynaecol.Res.23. 103-110 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] S.Fujimoto: Recent advance in diagnosis of preterm premature rupture of the membranes. Hokkaido University School of Medicine, 1-77 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 佐川 正: "preterm PROMの予防は可能か" 臨床婦人科産科. 52・5. 668-673 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 佐川 正: "教室におけるpreterm PROM(PPROM)の診断・管理とその予防について" 日本産科婦人科学会雑誌. 50・9. N283-N286 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 佐川 正: "切迫早産の予知は可能か" 産科と婦人科. 64・3. 312-318 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 佐川 正: "妊婦の頸管粘液中のサイトカイン動態" 産婦人科治療. 75・5. 559-563 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 佐川 正: "破水を疑ったときの検査" ペリネイタル ケア. 16・12. 1147-1155 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tadashi Sagawa: "Cytokines Concentrotions in the Cervical Mucus of Pregnant women" J. Obstet Gynaecol. Res.22・5. 517-522 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 佐川 正: "子宮内感染と羊水情報" ペリネイタルケア. 15・6. 491-496 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sayeda Begum: "Screening for Bacterial Vaginosis and Cervivcitis Aimed at Preventing Premature Delivery" J. Obstet Gynaecol. Res.23・1. 103-110 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 藤本征一郎: "切迫早産の診断法と治療" 日産婦誌. 48・3. N43-N46 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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