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HPV,host defense, and enviromental factors in histogenesis of cervical cancer

Research Project

Project/Area Number 08671860
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionTohoku University

Principal Investigator

KANNO Ryo  Tohoku Univ.Ob/Gyn.Lecturer, 医学部附属病院, 講師 (70271905)

Co-Investigator(Kenkyū-buntansha) TAKANO Tadao  Tohoku Univ.Ob/Gyn, Research Associate, 医学部附属病院, 助手 (40282058)
SATO Shinji  Tohoku Univ.Ob/Gyn.Lecturer, 医学部, 講師 (10142960)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1997: ¥300,000 (Direct Cost: ¥300,000)
Keywordscervical cancer / dysplasia / HPV (human papilloma virus) / p53 / apoptosis / bcl 2 / retinoid
Research Abstract

Alterations of the p53 gene are common in human malignancies. HPV infection contributes to carcinogenesis in cervical carcinoma. Inaddition, the abnormal expression of the bcl-2 protein inhibits apoptosis in some carcinomas. We investigated the expression of the p53 protein, p53 mutations, the presence of HPV DNA,and the expression of the bcl-2 protein in cervical squamous cell carcinomas. Some cervical carcinomas which have wild-type p53 protein may have developed from the inhibition of apoptosis secondary to bcl-2 protein overexpression. The present results suggest that oervical carcinoma differs from other common human malignancies in the manner in which p53 gene alterations are involved in carcinogenesis.
To evaluate the clinical significance of human papillomavirus (HPV) type, the grade of cervical intraepithelial neoplasia (CIN), and age on the progression of CIN.Clinical follow-up data, histopathologic diagnosis, polymerase chain reaction (PCR) detemined HPV DNA typing were analyzed. HPV positivity (P=.0466), especially HPV16 positivity (P=.0104), was significantly more frequent than HPV negativity in the progression group. Multiple logistic regression analysis revealed that HPV (odds ratio 2.23, P=.0103) and the grade of the lesion (odds ratio 3.30, P=.0002) in the initial biopsy strongly and independently correlated with progression of CIN.HPV status and histologic grade are independent predictive risk factors for progression and may be useful in the management of CIN.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Pqez, C, Kouno R et al: "Prevalence of HPVDNA in cervical lesions in Patients from Ecuador and Japan" Tohdcu J Exp Med. 180. 261-272 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 今野 良, 佐藤 信二, 他: "子宮頚癌とHPV" 産婦人科の実際. 45. 299-304 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 今野 良, 佐藤 信二, 他: "子宮頚部境界悪性病変" 臨床婦人科産科. 50. 990-993 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 今野 良, 佐藤 信二, 他: "子宮頚部異形成の悪性への進行とHPVとの関連" 産婦人科の世界. 49. 9-16 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Konno R, Sato S et al: "HPV,histologic grade and age.Risk factors for pognession of cervical intraepithelial neoplasia" J Reprod Med. (in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Paez.C,Konno R.et al: "Prevalence of HPV DNA in Cervical lesions in Patients from Ecuador and Japan." Tohoku J Exp Med. 180. 261-272 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Konno R,Sato S,et al: "HPD,histologic grade and age. Risk factors for progression of cervical intraepithelial neoplasia." J.Reprod.Med.(in press).(1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Paez,C, Konno R et al: "Prevulence of HPD DNA in Cervical lesions in Patients from Ecuador and Japan" Tohdcu J Exp Med. 180. 261-272 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 今野良, 佐藤信二、他: "子宮頚癌とHPV" 産婦人科の実際. 45. 299-304 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 今野良、佐藤信二、他: "子宮頚部境界悪性病変" 臨床婦人科産科. 50. 990-993 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 今野良、佐藤信二、他: "子宮頚部異形成の悪性への進行とHPVとの関連" 産婦人科の世界. 49. 9-16 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Konno R, Sato S et al: "HPV,histologic Grade and Age. Risk factors for progremin of cervical intraepithelial neoplasia" J Reprod Med.(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Paez. C, Kaino, R et al: "Prevalence of HPVDNA in Cervical Lesions in Patients from Ecuador and Japan" Tohoku J. Exp. Med.180. 261-272 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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