| Project/Area Number |
08671878
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | YAMANASHI MEDICAL UNIVERSITY |
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Principal Investigator |
YASUMIZU Takehiko YAMANASHI MEDICAL UNIVERSITY,MEDICAL FACULTY,ASSOCIATE PROFESSOR, 医学部, 助教授 (80107705)
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| Co-Investigator(Kenkyū-buntansha) |
IIJIMA Sumio YAMANASHI MEDICAL UNIVERSITY,MEDICAL FACULTY,ASSOCIATE PROFESSOR, 医学部, 助教授 (70114361)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Bone matabolism / PICP / ICTP / Bone mineral density / Pregnancy / Postpartum / Lactation |
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| Research Abstract |
(1) To reassess the clinical utility of serum pyridinoline cross-linked carboxy terminal telopeptide of type I collagen (ICTP), a promising but controversial indicator of bone resorption, we evaluated its performance as a biochemical marker in a 6-month study of a strictly selected population of 76 Japanese postmenopausal and healthy women, 33 recipients of hormone replacement therapy and 43 non-recipients. We measured bone mineral density (BMD) of the lumbar spine (L2-L4), and serum ICTP,carboxyterminal propeptide of type I procollagen (PICP) and other conventional serum biochemical markers at the entry and 6 months later. Among the biomarkers measured, the percent change in ICTP correlated with that in BMD to the highest degree (P<0.0001). We concluded that serum ICTP is a sensitive and useful bone resoption marker in the postmenopausal population, which strongly correlates with the change in BMD.
(2) A longitudinal study was performed to investigate postpartum changes in human bone m
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etabolism and the effects of lactation on them. The subjects consisted of two groups : 13 women who stopped breast-feeding within 3 months postpartum (short-term group) and 14 women who continued breast-feeding for more than 6 months postpartum (long-term group). Between prepartum and 3 months postpartum, the values and variations of serum PICP and ICTP were essentially the same in both groups. PICP was maintained at a constant and significantly higher level than the control value. In contrast, ICTP had increased markedly at 5 days postpartum, gradually decreasing thereafter. At 9 months postpartum, PICP and ICTP decreased to the control values in the short-term group. The postpartum time course of lumbar BMD showed a significant decrease in both groups at 3 months at 3 months postpartum and a recovery to the puerperal level in the short-term group but not in the long-term group at 9 months postpartum. In conclusion, bone resorption is stimulated by parturition as well as lactation resuting in postpartum loss of lumbar BMD. Less
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