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Research for the perinatal adaptation of fetus and newborn ; relation to apoptosis and growth factor

Research Project

Project/Area Number 08671895
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionOkayama University

Principal Investigator

HIRAMATSU Yuji  Okayama University Medical School Hospital, Lecturer, 医学部・附属病院, 講師 (80218817)

Co-Investigator(Kenkyū-buntansha) MASUYAMA Hisashi  Okayama University Medical School Hospital, Senior resident, 医学部・附属病院, 医員
MIZUTANI Yasushi  Okayama University Medical School Hospital, Assistant, 医学部・附属病院, 助手 (20294465)
KAMIMURA Shigehito  Okayama University Medical School Hospital, Assistant, 医学部・附属病院, 助手 (90281154)
NAKATA Takakimi  Okayama University Medical School Hospital, Senior resident, 医学部・附属病院, 医員
河原 伸明  岡山大学, 医学部・附属病院, 医員
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
Keywordsfetus / newborn / perinatal period / epidermal growth factor / polyamine / heme metabolism / diabetes mellitus / placenta / ポリアミン / DFMO / 胎児発育 / EGF / Apoptosis / 糖代謝
Research Abstract

Fetus and newborn show the many physiological and metabolic changes to adapt the dramatic environmental changes around the delivery. We investigated the hormones, growth factors and substances related to these changes.
EGF increased fetal weight by controlling the amino acid transport in placenta. Retinol, insulin and insulin like growth factor also increased amino acid transport. EGF promoted the functional and morphological development of neonatal rat intestine and this change was inhibited by DL-α-difluoromethyl ornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC).
Inhibition of polyamine synthesis by DFMO also induced intrauterine growth restriction. The depression of ODC activity in the placenta is the major factor of IUGR induced by DEMO administration, and polyatnines play important roles to carry pregnancy.
We investigated heme metabolism in placenta. Transcription levels of the non-specific δ-aminolevulinate synthase and heme oxygenase-1 in placenta at the terminal stage of pregnancy were increased markedly and these enzymes were exclusively expressed in the trophoblast. Both enzymes were influenced by acute fetal hypoxia and suggest that placental heme metabolism is influenced by the oxygen supply.
We established a sireptozotocin (STZ)-treated pregnant rat model with diabetes and signs and symptoms mimicking preeclampsia. This model closely is useful for basic study of the pathophysiology of pregnancy with diabetes.
These data suggest that many hormones, growth factors and substances such as EGF, polyamine, insulin, retinoids which related to cell growth play some important roll during the perinatal period.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Masuyama H: "Effect of epidernal growth foctor on placental aminoacid and regulation of epicurmal growth fortor receptor expression of hepetocyle in rat"J.Perinat.Mecl. 24. 213-220 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 西井 英: "Epidermol Growth Factor (EGF)の新生仔ラット消化管発育に及ぼす影響"第32回 日本新生児学会抄録集. 207 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 石原 剛: "胎児発育からみた妊娠中毒症の検討"日本妊娠中毒症学会雑誌. 4. 225-226 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 伊原 直美: "ラット胎生期におけるヘム代謝の動態に関する研究"日産婦栄代誌. 3. 53-54 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ishida M: "Effects of EGF and palyamine in fetal and reonatal growth"Acta Obstet.Gynecol.Scand.. Supple76(167). 95 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 平松 祐司: "胎盤と疾患 ―― IUGR"周産期医学. 28. 787-791 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Noomi Ihara: "Developmontal charges of gene expression in heme metabolic engymes in rat placenta"FEBS Letters. 439. 163-167 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 石田 理: "胎仔発育におけるポリアミンの役割に関する研究"日産婦誌. 50 Suppl. S220 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 石原 剛: "妊娠糖尿病とSyndrome Xに関する研究"日産婦栄代誌. 5. 44-45 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Go Ishihara: "Streptozoto cin induced diabetic pregnant rats exhibit the signs and symptoms mimicling preeclampsia"(in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Masuyama H, Hiramatsu Y, Kudo T: "Effect of epidermal growth factor on placental amino acid transport and regulation of epidermal growth factor receptor expression of hepatocyte in rat"J Perinat Med. 24. 213-220 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nishii E, Hiramatsu Y, Ishida M, Nakata T, Ihara N, Odaka K, Kamimura S, Kudo T: "Effects of epidermal growth factor on neonetal intestinal development in rats"Proceeding of the 32nd Annual Congress of Jaoan Society of Neonatology. 207 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ishihara, G: "Relationship and fetal growth and preeclampsia"Journal of Japan Society for the Study of Toxemia of Pregnancy. 4. 225-226 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ihara, N: "Developmental changes of heme metabolism in fetal period"J. Jpn. Soc. Study Women's Nutr. Metab. 3. 53-54 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ishida M, Hiramatsu Y, Nishii E, Odaka K, Mizutani Y, Kamimura K, Kudo T: "Effects of EGF and polyamine in fetal and neonatal growth"Acta Obstet Gynecol Scand. Suppl76, No 167. 95 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hiramatsu Y, Ishihara G, Kudo T: "placemta and Disease : Intrauterine growth restriction"Perinatal medicine. 28. 787-791 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Naomi Ihara, Reiko Akagi, Kohei Ejiri, Takafumi Kudo, Kazumichi Furuyama, Hiroyoshi Fujita: "Developmental changes of gene expression in heme metabolic enzymes in rat placenta"FEBS Letters. 439. 163-167 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ishida M, Hiramatsu Y, Nishii E, Nakata T, Masuyama H, Mizutani Y, Kudo T: "Roll of polyamine in fetal growth"Acta Obstet Gynecol Jap. 50 Suppl. S-220 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ishihara, G: "Study for the relationship between diabetes mellitus and syndrome X in pregnant women"J. Jpn. Soc. Study Women's Nutr. Metab. 5. 44-45 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Go Ishihara, Yuji Hiramatsu, Hisashi Masuyama, Takafumi Kudo: "Streptozotocin induced diabetic pregnant rats exhibit the signs and symptoms mimicking prceclampsia"Metabolism. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 伊原 直美: "ラット胎生期におけるヘム代謝の動態に関する研究" 日本産婦人科栄養・代謝研究会誌. 3・1. 63-64 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Maenyama,Y.Hiramatsu,T.Kudo: "Effecte of eprdormal growth factor on placeutal aminoacid transport and regulation of eprdermal growth factor receptor expression of hepatecyte in rat" J.Peprimotal Medicine. 29. 213-220 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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