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Study on fetal growth and hemodynamics in human multiple pregnancies

Research Project

Project/Area Number 08671902
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

SATOH Shoji  Kyushu Univ., Department of Obstet. Gynecol. Senior Lecturer, 医学部, 講師 (00225947)

Co-Investigator(Kenkyū-buntansha) TSUKIMORI Kiyomi  Kyushu Univ., Department of Obstet. Gynecol. Senior Lecturer, 医学部, 講師 (90253450)
KOYANAGI Takashi  Kyushu Univ., Department of Human Development, professor, 大学院・医学系研究科, 教授 (30136452)
NAKANO Hitoo  Kyushu Univ., Department of Obstet. Gynecol. Professor, 大学院・医学系研究科, 教授 (40038766)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1998: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordshuman fetus / twin pregnancy / fetoplacental circulation / fetal growth / twin-twin transfusion / discordant twin / placental pathology / 心拍数変動 / 卵性 / 生物時計 / 胎児循環動態 / Discordancy / 胎盤循環 / クラスター分析
Research Abstract

1) To clarify whether twin fetuses could be clustered quantitatively observing in utero cardiovascular system function, 71 twin-paired fetuses between 24 and 40 weeks' gestation were clustered with EDD, FS, RI in the umbilical artery and UPR. Three different groups were revealed. In cluster 1 (C1), larger fetuses showed a significant increase in both EDD and UPR, and a significant decrease in FS, while smaller fetuses had a significant increase in RI and a decrease in UPR. In cluster 2 (C2), smaller fetuses showed a significant increase in RI. Cluster 3 (C3) showed no significant deviations in any variable when referring to singleton pregnancies. C1 had a higher perinatal mortality rate than either C2 or C3, with the cause of death being cardiac failure in larger fetuses and renal failure in smaller fetuses. The frequencies of discordancy, hemoglobin difference above 5g/dl and monochorionic placenta in C1 were also higher than fetuses in C3. C2 also showed higher frequencies of discord … More ancy and small-for-gestational age than C3 fetuses. In C2 and C3, respiratory insufficiency was found to be the cause of neonatal death. The results revealed that C1 consists of twins with both larger and smaller fetuses displaying cardiac failure with an increase in renal perfusion and a decrease in renal and placental perfusion, respectively, and C2 consists of twin s with smaller fetuses having both placental insufficiency and intrauterine growth retardation. C3 consists of twins with both larger and smaller fetuses having normal circulation.
2) Qualitative analysis of blood velocity in the umbilical arteries and superficial placental vessels in 5 cases of twin pregnancy revealed abnormal patterns, permitting accurate antenatal diagnosis of artery-to-artery anastomoses, using color flow mapping and pulsed Doppler velocimetry. These 5 cases, of which 3 cases manifested clinical signs of twin-to-twin transfusion syndrome, had monochorionic-diamniotic placentas with superficial artery-to-artery anastomoses. These results indicate that periodic alterations of blood flow velocity waveforms are useful in detecting artery-to-artery anastomoses, a direct finding in monozygotic twins in utero. Less

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] S. Yanai, et al.: "Can twin fetuses be numerically clustered characterizing fetal cardiovascular system function?"Early Human Development. 48(1-2). 117-129 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T. Koga, et al.: "Prenatal diagnosis of vascular anatomosis on the placental surface in twin pregnancy"Advances in Obstetrics and Perinatology. 9. 113-117 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 柳井繁章ら: "発作性上室性頻拍を合併した胎児心房中隔瘤の1症例"日本産科婦人科学会雑誌. 51. 145-149 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Satoh S., et al.: "Clinical applications of the Doppler technique in monitoring the fetus"Clinics in Perinatology. 26. 853-867 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] S. Yanai: "Can twin fetuses be numerically clustered characterizing fetal cardiovascular system function?"Early Human Development. 48. 117-129 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T. Koga: "Prenatal diagnosis of vascular anastomosis on the placental surface in twin pregnancy"Advances in Obstetrics and Perinatology. 9. 113-117 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] S. Yanai: "Antenatal diagnosis of fetal atrial septal aneurysm possibly causing paroxysmal supraventricular tachycardia"Acta Obstetrica and Gynaecologa Japonica. 51. 145-149 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] S. Satoh: "Clinical applications of the Doppler technique in monitoring the fetus"Clinics in Perinatology. 26. 853-867 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] S.Yanai,et al.: "Can twin fetuses be numerically clutered characterizing fetal cardiovascular svstem function?" Early Human Development. 48(1-2). 117-129 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Koga,et al.: "Prenatal diagnosis of vasular anastomosis on the placental surface in twin pregnancy." Advances in Obstetrics and Perinatology. 9. 113-117 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] A.A.Banu: "Doppler velocimeutry in the umbilical and middle cerebral arteries in fetuses with intra-uterine growth retardation or fetal distress." Fukuoka Acta Medica. 89. 133-144 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 柳井繁章ら: "発作性上室性頻拍を合併した胎児心房中隔瘤の1症例" 日本産婦人科学会雑誌. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Yanai S.et al.: "Can twin fetuses be numerically clusrtered characterizing fetal cardiovascular system function?" Early Human Development. 48. 117-129 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yanai S.et al.: "Can twin fetuses be numerically clustered characterizing fetal cardiovascular system function?" Early Humen Development. (in press). (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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