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High-dose chemotherapy with a support of autologous stem cell transplantation in advanced and refractory ovarian cancer.

Research Project

Project/Area Number 08671932
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionTokai University

Principal Investigator

SHINOZUKA Takao  Tokai Univ.School of Med.Associate Professor., 医学部, 助教授 (30110901)

Co-Investigator(Kenkyū-buntansha) OSAMURA Yoshiyuki  Tokai Univ.School of Med.Professor, 医学部, 教授 (10100992)
MURAMATSU Toshinari  Tokai Univ.School of Med.Instructor, 医学部, 助手 (90266437)
MIYAMOTO Tsuyosi  Tokai Univ.School of Med.Instructor, 医学部, 助手 (60209947)
MURAKAMI Masaru  Tokai Univ.School of Med.Assistant Professor, 医学部, 講師 (00190893)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
Keywordsovarian carcinoma / high-dose chemotherapy / autologous bone marrow transplantation / prognostic factor / long-term follow up / 超大量化学療法 / 卵巣癌
Research Abstract

BACKGROUND.Next results were obtained by high dose chemotherapy(HDC) with autologous bone marrow transplantation in advanced and refractory ovarian cancer.
PATIENTS AND METHODS.After maximum debulking surgery of the 105 epithelial ovarian cancer patients, HDC with stem cell support was given composed of cyclophosphamide 1600-2400 mg/m^2 adriamycin 80-100 mg/m^2+ cisplatin 100-150 mg/m^2(n=58), or carboplatin 900-1500 mg/m^2+ cyclophosphamide 3000 mg/m^2. ABMT or PBSCT were performed 48 hours or 72 hours after HDC, respectively.
RESULTS.Five- and 8-years overall survivals(OS) by FIGO stage were I c(n13) : 92.3%.92.3%, II (n=12) : 73.3%.73.3%, LII (n=46) : 58.1%.48.8%, lV(n=19) : 33.7%. 33.7% , relapsedlrefractory(n=15) : 37.5%.37.5% , and disease free survival(DFS) were I c : 92.3%.92.3%, II : 73.3%.73.3%, III : 35.7%.31.7%, IV : 22.6%.22.6% , relapsedlrefractory : 31.0%.31.0%. In 65 stage 1III/V patients, 5-year OS accordinng to the residual tumor size before performing HDC were 0-0.5 cm (n=35) : 74.3%, 0.6-2 cm(n=13) : 30.8%, >2 cm(n=17) : 22.6%. Best results of long long term survival were obtained in 35 patients with small volume residual disease(0-0.5cm). Histologically, patients with mucinous and clear cell adenocarcinoma showed significantly worse long term survivals than other histologies.
FUTURE STRATEGY.For better long term survivals, we are now planning HDC with peripheral blood stem cell transplantation containg multi drugs including pacitaxel, which sensitive for epithelial ovarian cancers.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (34 results)

All Other

All Publications (34 results)

  • [Publications] 篠塚 孝男 他: "卵巣癌大療化学療法における骨髄抑制に対する末梢血幹細胞移植法の効果" Oncology & Chemotherapy. 12. 107-112 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 篠塚 孝男 他: "末梢血幹細胞移植・G-CSF併用による進行卵巣癌の治療" Oncology & Chemotherapy. 13. 83-86 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 篠塚 孝男 他: "超大量化学療法" 癌の臨床 臨時増刊号. 43. 1391-1400 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 篠塚 孝男 他: "婦人科癌の最新治療動向 特集. 卵巣癌の最新治療動向 : 新しい化学療法〜高濃度化学療法の意義(PBSCTを主に)〜" 癌治療と宿主. 10. 50-56 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 篠塚 孝男 他: "表層上皮性卵巣悪性腫瘍での治療成績(特集 婦人科癌に対する造血幹細胞移植)" Oncology & Chemotherapy. 14. 227-231 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shinozuka T, et al.: "High-dose chemotherapy with autologous stem cell support in patients. with ovarian cancer : Long-term results of 105 patients." Cancer.(in press.). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 篠塚 孝男: "婦人科がん治療学-4. 卵巣癌. D薬物療法" 金原出版(株), 野田 起一朗 監修 野澤 茂朗, 大川 智彦 編集., 426 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 篠塚 孝男: "新臨床外科学(第3版)-4. 婦人科腫瘍" (印刷中),

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shinozuka T,et al.: "Efficacy of peripheral blood stem cell transplantation in high dose chemotherapy against ovarian cancer." Oncology and Chemotherapy. 12. 107-112 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shinozuka T,et al.: "Peripheral blood stem cell transplantation in combination with G-CSF administration in the treatment of advanced ovarian cancer." Oncology and Chemotherapy. 13. 83-86 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shinozuka T,et al.: "Ultra-high dose chemotherapy." JP J Cancer Clinic. 43. 1391-1400 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shinozuka T,et al.: "New approach for the treatment of ovarian cancer-high dose chemotherapy with peripheral blood stem cell transplantation." Cancer Therapy & Host. 10. 50-56 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shinozuka T,et al.: "Results of high dose chemotherapy with hematopoietic stem cell support in epithelial ovarian cancer." Oncology and Chemotherapy. 14. 227-231 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shinozuka T,et al.: "High-dose chemotherapy with autologous stem cell support in the treatment of patients with ovarian carcinoma." Long-term results for 105 patients.Cancer. (in press.). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shinozuka T.: Chemotherapy.In : Nozawa S,Ookawa T,eds.Therapeutics in Gynecological Cancers : Ovarian cancer. Tokyo : Kanehara & Co LTD., 426 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shinozuka T.: Gynecologic tumor.In : New Clinical Surgery. Tokyo : Igakushoin ; in press., (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 篠塚 孝男 他: "婦人科癌の最新治療動向 特集.卵巣癌の最新治療動向:新しい化学療法〜高濃度化学療法の意義(PBSCTを主に)〜" 癌治療と宿主. 10. 50-56 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 篠塚 孝男 他: "表層上皮性卵巣悪性腫瘍での治療成績(特集 婦人科癌に対する造血幹細胞移植)" Oncology & Chemotherapy. 14. 227-231 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shinozuka T,et al.: "High-dose chemotherapy with autologous stem cell support in patients.with ovarian cancer:Long-term results of 105 patients." Cancer.(In press.). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 篠塚 孝男: "婦人科がん治療学-4.卵巣癌.D薬物療法" 金原出版(株).野田起一郎 監修 野澤 志朗,大川 智彦 編集, 426 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 篠塚 孝男: "新臨床外科学(第3版)-4.婦人科腫瘍" (印刷中),

    • Related Report
      1998 Annual Research Report
  • [Publications] Shinozuka T.: "High-dose chemotherapy with hematopoietic progenitor cell support in patients with epithelial ovarian canoer:Lorg te resul" Proc Am Soc Clin Oncol. 16. 378a (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 篠塚 孝男: "末梢血幹細胞移植,G-CSF併用による進行卵巣癌の治療" Oncol.Chemothera. 13. 83-86 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 篠塚 孝男,宮本 壮: "超大量化学療法" 癌の臨床. 43・11. 1391-1400 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 篠塚孝男,宮本壮,村松俊成,牧野恒久: "進行再発卵巣癌に対する自家骨髄移植(ABMT)法を併用した大量CAP療法" 産婦人科の世界. 49・6. 55-60 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 篠塚 孝男,宮本 壮: "卵巣癌化学療法におけるPBSCTの適応と方法" 産婦人科の実際. 46・1. 63-69 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 篠塚 孝男,平澤 猛: "末梢血幹細胞移植による進行卵巣癌の治療" 臨床婦人科産科. 51・7. 739-744 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 篠塚 孝男: "婦人科がん治療学ー卵巣癌・薬物療法" 金原出版(株),野田起一郎(監修) 野澤志朗(編集),大川智彦(編集), 426 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 篠塚孝男: "造血幹細胞移植法を併用した卵巣癌の超大量化学療法" 日本産婦人科・新生児血液学会誌. 5・4. 117-127 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 篠塚孝男: "進行卵巣癌に対する末梢血幹細胞移植法" 産婦人科の実際. 45・3. 331-337 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 宮本壮 篠塚孝男: "卵巣癌大量化学療法における骨髄抑制に対する末梢血幹細胞移植法の効果" Oncology & Chemotherapy. 12・2. 107-112 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 篠塚孝男: "造血幹細胞移植を応用した卵巣癌治療" Bio therapy. 10・9. 1139-1146 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 篠塚孝男: "卵巣癌化学療法におけるPBSCTの適応と方法」" 産婦人科の実際. 46・1. 63-69 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 篠塚孝男: "末梢血幹細胞移植.G-CSF併用による進行卵巣癌の治療" Oncology & Chemotherapy. 13・2. (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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