| Project/Area Number |
08671934
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tokyo Women's Medical College (T.W.M.C) |
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Principal Investigator |
TAKAGI Koichiro Tokyo Women's Medical College (T.W.M.C) School of Med., Associate professor, 医学部, 助教授 (90154749)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAI Keiji Tokyo Women's Medical College (T.W.M.C) School of Med., Resident, 医学部, 助手 (30260962)
MURAOKA Mitsue Tokyo Women's Medical College (T.W.M.C) School of Med., Assistant professor, 医学部, 講師 (60147387)
吉岡 美和子 東京女子医科大学, 医学部, 助手 (90256587)
斉藤 理恵 東京女子医科大学, 医学部, 助手 (20225741)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1997: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | nitric oxide / pregnancy / intrauterine growth restriction / hypoxia / perinatal period |
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| Research Abstract |
Gene expression of the endothelial nitric oxide synthase (eNOS) was examined by competitive reversed polymerase chain reaction (RT-PCR) assay in rat fetal organs with intrauterine growth restriction (IUGR). Both fetuses and placentas from the uterine horns with ligation to the uterine artery were significantly smaller than those of the contralateral horns of the uteri. Messenger RNA (m RNA) abundance of eNOS in the placenta with IUGR was significantly less than that of the control. Messenger RNA abundance in the fetal brain and liver was below detection limit of our assay. Unlike preproendothelin-1 m RNA,eNOS m RNA level in the kidney with IUGR showed no significant change with hypoxia.
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