EVALUATION FOR RISK CAUSED BY PRENATAL STRESS-ITS ENDOCRINOLOGICAL BACKGROUND
Project/Area Number |
08671941
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | TEIKYO HEISEI UNIVERSITY (1998) Teikyo University Junior College (1996-1997) |
Principal Investigator |
OHKAWA Tomi TEIKYO HEISEI UNIVERSITY, DEPT. OF INFORMATICS, ASSOCIATE PROFESSOR, 情報学部, 助教授 (30101695)
|
Project Period (FY) |
1996 – 1998
|
Project Status |
Completed (Fiscal Year 1998)
|
Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥600,000 (Direct Cost: ¥600,000)
|
Keywords | PREGNANCY / PRENATAL STRESS / BETA-ENDORPHIN / SEX STEROID / SDN-POA / BEHAVIOR / RAT / ストレス / 胎仔 / ACTH / オピオイド / 性スラロイド / アロマターゼ |
Research Abstract |
In this study the risk caused by stress during pregnancy was evaluated in view of its endocrine and behavioral deviations in the offspring of the rat. Under maternal stress, plasma testosterone and hypothalamic aromatase activity decreased in the male offspring. The increased plasma corticosterone and decreased hypothalamic CRH were also observed, suggesting stress response of the fetus itself and the suppression of CRH caused by maternal corticosterone. The SDN-POA area of the male offspring decreased correlating to the strength of the stress, which was the result of the decrease in the level of plasma testosterone and hypothalamic aromatase activity in the perinatal period. The prenatal stress affected stress response of the immature male offspring, in which female type of plasma ACTH release was observed in the males experienced the strongest prenatal stress. The playing behavior and male-typical sexual behavior were demasculinized by the prenatal stress. The open field activity was diminished and open field emotionality was enhanced by the prenatal stress. The opioid blocker given prior to the stress exposure effectively prevented the demasculinization of the playing behavior and male-typical sexual behavior, however it prevented the alterations in open field behavior only in the male offspring. These results indicate that the stress-induced activation of beta-endorphin system may be one of the factors, which cause behavioral deviations in the offspring.
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Report
(4 results)
Research Products
(4 results)