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Gas exchange via the mucosa in the middle ear cleft -comparative study of normal ears and inflamed ears-

Research Project

Project/Area Number 08671954
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionNiigata University

Principal Investigator

NONOMURA Naobumi (1997-1998)  Niigata University, School of Medicine, Associate Professor, 医学部, 助教授 (00156217)

中野 雄一 (1996)  新潟大学, 医学部, 教授 (80018316)

Co-Investigator(Kenkyū-buntansha) IKARASHI Fumio  The Nippon Dental University, School of Dentistry at Niigata, Professor, 新潟歯学部, 教授 (30176060)
TAKAHASHI Sugata  Niigata University, School of Medicine, Professor, 医学部, 教授 (10154824)
野々村 直文  新潟大学, 医学部, 助教授 (00156217)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1998: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordsmiddle ear cleft / gas exchange / mucosa / normal ear / inflamed ear
Research Abstract

Experimental study : Using the normal middle ear of the pig, the relationship between the respiratory condition and middle ear pressure was examined. The partial pressure of carbon dioxide in the venous blood and the middle ear pressure were decreased by hyperventilation, and increased by hypoventilation. These findings suggest that bidirectional gas exchange induced by gas diffusion between the middle ear cleft and capillaries in the submucosal connective tissue acts in the normal middle ear. The capacity of gas exchange via the mucosa was also examined in the inflamed ear. Inflammation was induced in the middle ear cleft of the pig and the same experiment in the normal ear was conducted. In some cases, the middle ear pressure changed according to the respiratory condition as in normal ears, whereas in some cases, no apparent change in the middle ear pressure was observed, Based on histological study and quantitative analysis by histomorphometry, it was revealed that gas exchange via the mucosa was impaired by middle ear inflammation, and the degree of impairment was directly proportional to the ratio of the diseased mucosa in the residual middle ear air cell system.
Clinical study : In subjects with normal middle ears, the middle ear pressure was measured while the hyperventilation and hypoventilation was repeated in the supine position. As in the experimental study, the partial pressure of carbon dioxide in the venous blood and the middle ear pressure were decreased by hyperventilation, and increased by hypoventilation, These findings suggest that bidirectional gas exchange acts in the normal human middle ear as well. Gas exchange via the mucosa was examined in the ear exhibited mild otitis media with effusion with type C_2 tympanogram. The findings showed that the capacity of gas exchange via the mucosa was not impaired in the mild otitis media with effusion.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] 山本 裕、 他: "ブタ中耳圧の変化〜正常耳と炎症耳の比較〜" Otology Japan. 6. 405 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fumio Ikarashi, et al: "Pneumatiztion of the tympanic bulla after blockage of the ventilation route through the eustachian tube in the pig" ANNALS OF OTOLOGY, RHINOLOGY & LARYNGOLOGY. 105. 784-790 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 山本 裕、他: "ブタ炎症耳の中耳圧変化-圧変化と組織所見の検討-" Otology Japan. 7. 301 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 五十嵐文雄、他: "中耳腔の経粘膜換気-呼吸状態と中耳圧-" Otology Japan. 7. 302 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 山本 裕、他: "ブタ炎症耳の経粘膜換気能 -含気蜂巣の炎症所見との関係-" Otorogy Japan. 8. 433 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fumio Ikarashi: "The effect of respiratory mode on human middle ear pressure" Auris Nasus Larynx. 25. 349-354 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yamamoto Y,Okura T,Hanazawa H,Nakano Y,Ikarashi F: "Middle ear pressure change in piglets -Comparative study between normal and inflamed ears-" Otology Japan. 6. 405 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ikarashi F,Nakano Y,Okura T: "Pneumatization of the tympanic bulla after blockage of the ventilation route through the eustachian tube in the pig" Ann Otol Rhinol Laryngol. 105. 784-790 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yamamoto Y,Hanazawa H,Nakano Y,Ikarashi F: "Middle ear pressure change in piglets -Relationship between the pressure change pattern and histological findings-" Otology Japan. 7. 301 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ikarashi F: "Gas exchange function through the middle ear moucosa -Relationship between the respiratory mode and middle ear pressure-" Otology Japan. 7. 302 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yamamoto Y,Hanazawa H,Takahashi S,Nakano Y,Ikarashi F: "Gas exchange function through the middle ear mucosa in inflamed ear" Otology Japan. 8. 433 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ikarashi F: "The effect of respiratory mode on human middle ear pressure" Auris Nasus Larynx. 25. 349-354 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 山本 裕、他: "ブタ炎症耳の経粘膜換気能-含気蜂巣の炎症所見との関係-" Otology Japan. 8・4. 432 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fumio Ikarashi: "The effect of respiratory mode on human middle ear pressure" Auris Nasus Larynx. 25・4. 349-354 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 山本 裕、他: "ブタ炎症耳の中耳圧変化-圧変化と組織所見の検討-" Otology Japan. 7・4. 301 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 五十嵐文雄、他: "中耳腔の経粘膜換気-呼吸状態と中耳圧-" Otology Japan. 7・4. 302 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 山本裕、他: "ブタ中耳圧の変化〜正常耳と炎症耳の比較〜" Otology Japan. 6・4. 209- (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Fumio Ikarashi,et al.: "Pneumatization of the tympanic bulla after blockage of the ventilation route through the eustachian tube in the pig" ANNALS OF OTOLOGY,RHINOLOGY & LARYNGOLOGY. 105・10. 784-790 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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