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Do Waldeyer's ring tonsillar tissues function as an inductive site and/or effector site of antigen-specific immune response for systemic immunity and mucosal immunity as well?

Research Project

Project/Area Number 08671964
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionShimane Medical University

Principal Investigator

IWAMOTO Jun-ichi (1997-1998)  Shimane Medical Univ. Dept. of Otolaryngology, Assistant, 医学部, 助手 (20284036)

柴 宏巳 (1996)  島根医科大学, 医学部, 助手 (30281760)

Co-Investigator(Kenkyū-buntansha) KAWAUCHI Hideaki  Shimane Medical Univ. Dept. of Otolaryngology, Professor, 医学部, 教授 (50161279)
URABE Shinpei  Shimane Medical Univ. Dept. of Otolaryngology, Assistant (50232921)
SANO Keisuke  Shimane Medical Univ. Dept. of Otolaryngology, Assistant (10263542)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordstonsil / mucosal immunity / inductive site / effector site / NALT / NOD-scid mice / Phylogeny / 口蓋扁桃 / 免疫担当細胞 / ホーミング / ホ-ミング / 扁桃 / 陰窩 / リンパ濾胞
Research Abstract

We examined whether human tonsillar tissues function as an inductive site and/or effector site of antigen-specific immune response for systemic immunity and mucosal immunity as well, by employing experimental studies in mice and pigs and also in a transfer model of human tonsillar lymphocytes into NOD-scid mice. From the phylogenic standpoint, tonsillar tissues locate in different portion of the nasopharynx among different species, but they are commonly provided with squamous or columnar epithelia and crypt formation on the surface and lymphoid follicles and germinal center in the subepithelial region. Lymphoid tissues are composed of B cell and T cell areas. In a couple of animal experiments with immunological and molecular biology technique, it was demonstrated these waldeyer's ring equivalent tissues can be an inductive site of antigen-specific systemic and mucosal immunity and that nasopharyngeal mucosa can be an effector site as well. In transfer experiments of human tonsillar lymphocytes into NOD-scid mice, it was indicated that human tonsils have been continuously stimulated with nasopharyngeal resident microorganisms and therefore tonsillar lymphocytes are able to mount an antigen-specific immune response upon the subsequent antigenic exposure in various distant mucosal sites such as nasopharyngeal mucosae. Furthermore, experimental immunization protocols are still on-going in a syngeneic mini-pig model to have a definite conclusion.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] Hideyuki Kawauchi: "T-cell mucosal immunity in the nasopharynx."Proceedings of New Frontiers in Immunobiology. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 川内秀之: "上気道粘膜の生体防御機構と炎症性疾患の病態と治療"耳鼻咽喉科展望. 43(1). 10-22 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 川内秀之: "ヒト口蓋扁桃リンパ球のマウスへの移植の試み"日本耳鼻咽喉科感染症研究会会誌. 16(1). 60-66 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hideyuki Kawauchi: "The role of tonsils of as an Inductive site of Immune response in nasopharynx."Proceedings of the XVII th European Rhinologic Society and International Symposium on Infection and Allergy of the Nose. 83-87 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hideyuki Kawauchi: "Mucosal immunity of nasopharynx."Proceedings of the XVII th European Rhinologic Society and International Symposium on Infection and Allergy of the Nose. 89-93 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 川内秀之: "鼻粘膜における局所免疫応答機構の解析 -マウスを用いた実験的検討その2-"日本鼻科学会会誌. 36(2). 40-44 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 川内秀之: "上気道免疫の老化.治療80(3)"南山堂. 6 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hideyuki Kawauchi, Keisuke Sane, Hiromi Shiba, Chiaki Sano, Takaya Yamada, Tatsuo Suzuki: "T-cell mucosal immunity in the nasopharynx"New Frontiers in Immunobiology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Chiaki Sano, Toshiaki Shimizu, Hiroko Kajitani, Hideyuki Kawauchi, Haruaki Tomioka: "The modulating effects of proinflammatory cytokines, interferon-γ and tumor necrosis factor-α, and immunoregulating cytokines, IL-10 and transforming growth factor-β on antimicrobial activity of murine peritoneal macrophages against Mycobacterium avium-intracellulare complex"Clinical and Experimental Immunology. 115(3). 435-442 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Masashi Suzuki, Hideyuki Kawauchi, Goro Mogi: "Clinical efficacy of an antiallergic drug on otitis media with effusion in association with allergic rhinitis"Auris, Nasus, Larynx. 26(2). 123-129 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Masashi Suzuki, Hideomi Kerakawauchi, Hideyuki Kawauchi, Goro Mogi: "Efficacy of an antiallergic drug on otitis media with effusion in association with allergic rhinitis -An experimental study-"Annals of Otology, Rhinology & Laryngology. 108(6). 554-558 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hideyuki Kawauchi, Takaya Yamada, Keisuke Sano, Ryoutro Ishimitsu, Tatsuo Suzuki: "Mucosal immunity of nasopharynx-an experimental study in TCR-transgenic (OVA23-3) mice"Rhinology Supplement. 15. 56 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hideyuki Kawauchi, Keisuke Sano, Hiromi Shiba, Ryotaro Ishimitsu: "The role of tonsils of as an Inductive site of Immune response in nasopharynx"Proceedings of the XVII th European Rhinologic Society and International Symposium on Infection and Allergy of the Nose. 83-87 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hideyuki Kawauchi, Ryotaro Ishimitsu, Keisuke Sano, Takaya Yamada, Tatsuo Suzuki: "Mucosal immunity of nasopharynx"Proceedings of the XVII th European Rhinologic Society and International Symposium on Infection and Allergy of the Nose. 89-93 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 柴 宏巳: "ヒト鼻咽腔粘膜における抗原提示細胞の分布" 耳鼻咽喉科免疫アレルギー. 16(1). 21-25 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tomoko Nagata: "Conjugation of ubiquitin-like polypeptide to intracellular acceptor proteins" Biochimica et Biophysica Acta. 1401. 319-328 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 川内 秀之: "ヒト口蓋扁桃リンパ球のマウスへの移植の試み:NOD-scidマウスを用いた検討" 口咽科. 10(2). 149-160 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 川内 秀之: "ヒト口蓋扁桃リンパ球のマウスへの移植の試み" 日本耳鼻咽喉科感染症研究会会誌. 16(1). 60-66 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hideyuki Kawauchi: "Mucosal immunity of nasopharynx" Proceedings of the X VII th European Rhinologic Society and International Symposium on Infection and Allergy of the Nose. 83-87 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hideyuki Kawauchi: "The Role of Tonsils as an Inductive Site of Immune Response in Nasopharynx" Proceedings of the X VII th European Rhinologic Society and International Symposium on Infection and Allergy of the Nose. 89-93 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 川内秀之: "鼻咽喉の局所粘膜免疫応答における扁桃の役割" 口腔咽頭科. 8(3). 337-344 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hideyuki Kawauchi: "Mucosal immunity of nasopharynx : an experimental study in mice." Proceedings of the 16World Congressof Ptorhinolaryngology Head and Neck Surgery,Australoa,Sydney,March 2-7,1997. 1717-1720 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 川内秀之: "鼻粘膜における局所免疫応答機構の解析・マウスを用いた実験的検討-その2-" 日本鼻科学会誌. 36(2). 40-44 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 川内秀之: "TCRトランスジェニックマウス(OVA23-3)を用いた鼻粘膜局所免疫応答の実験的検討" 耳鼻咽喉科免疫アレルギー. 15(2). 158-159 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 柴 宏巳: "ヒト鼻咽腔粘膜における抗原提示細胞の分布について" 耳鼻咽喉科免疫アレルギー. 15(2). 166-167 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 川内秀之: "ヒト口蓋扁桃リンパ球のマウスへの移植の試み-NOD-scidマウスを用いた検討-" 日本耳鼻咽喉科感染症研究会会誌(発表予定). 16. (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 川内秀之: "JOHNS Vol.12.中耳の免疫と感染論" 東京医学社, 6 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 川内秀之: "医学のあゆみ177.Nasal tolerance(経鼻免疫寛容)と鼻疾患に対するその応用" 医歯薬出版, 4 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 川内秀之: "鼻咽腔の局所粘膜免疫応答における扁桃の役割" 口腔・咽頭科. 8(3). 337-344 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Taiji Katoh: "Intracranial Invasion of an Extramedullary Plasmacytoma in the Paranasal Sinus:A Case Report with a Reference to Magnetic Resonance Imaging." American Journal of Rhinology. 10. 371-376 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hideyuki Kawauchi: "Experimental and clinical study of azelastine hydrochloride on otitis media with effusion coupled with nasal allergy." Recent advances in otits media.461-463 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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