• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

IMMUNOLOGIC, GENETIC AND EPSTEIN-BARR VIROLOGICAL STUDIES OF MALIGNANCIES IN HEAD AND NECK LESION

Research Project

Project/Area Number 08671976
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionASAHIKAWA MEDICAL COLLEDE (1998)
Sapporo Medical University (1996-1997)

Principal Investigator

HARABUCHI Yasuaki  ASAHIKAWA MEDICAL COLLEDE,PROFESSOR, 医学部, 教授 (80208686)

Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1998: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1997: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
KeywordsHEAD AND NECK MALIGNANCIES / NASAL T / NK-CELL LYMPHOMA / EPSTEIN-BARR VIRUS / IMMUNOLOGY / VIROROGY / 上咽頭癌 / EBウィルス / NK細胞リンパ種 / 頭頚部 / 悪性腫瘍 / 耳下腺 / 鼻腔
Research Abstract

1) First, we investigated phenotypic, genotypic and Epstein-Barr virus (EBV) features of nasal T-cell lymphomas (NTL). We found that that NTL may be derived from the lineage of NK or N K-like T-cells and that EBV may play a role in the lymphomagenesis.
2) The levels of soluble intercellular adhesion molecule-1 (ICAM-1) were significantly higher in NTL than that in other head and neck lymphomas as well as that in healthy adult controls. The intense expression of the ICAM-1 was found in the tissues from NTL.These data may be one of the clue to an understanding of this particular lymphoma.
3) Analyses of prognostic factors non-Hodgkin's lymphoma of Waldeyer's ring revealed that prognosis was associated with primary disease in the base of tongue, stage III-IV, B-symptoms, highly histologic grade, T-cell phenotype, elevated LDH levels, decreased peripheral blood lymphocytes counts, or negative response on delayed type hypersensitivity skin reactions. Multivariate analysis showed that both stage III-IV and T-cell phenotype were significant independent risk factor for death.
4) Finally, we examined the presence of EBV in the lymphomas of sino-nasal region and determined its relation with clinical, phenotypic, and genotypic features. Twenty-three patients with nasal lymphomas had pan T-antigens MT1 and/or CD2 ; while all 7 sinus lymphomas displayed pan B-antigen L26. EBER transcripts were identified in 20 of 23 patients with NTL, but was never detected in sinus lymphomas. The natural killer (NK) cell phenotype CD56, monoclonal EBV genome, EBNA1, and LMP1, were detected in all EBER-positive NTL tested. The rearrangements of T-cell receptor (TCR) genes were shown in 11 of 1 3 NTL tested. NTL showed significantly lower survival rates as compared to the other types of sino-nasal lymphomas.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Harabuchi Y, Imai S, Wakashima J, et al.: "Nasal T-cell lymphoma causally associated with Epstein-Barr virus : Clinicopathologic, phenotypic, and genotypic studies." Cancer. 77. 2137-2149 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Harabuchi Y, Kataura A, Imai K.: "Circulating intercellular adhesion molecule-1 and its cellular expression in head and neck non-Hodgkin's lymphomas, including lethal midline granuloma." Ann Otol Rhinol laryngol. 105. 634-642 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Harabuchi Y, Tsubota H, Ohguro S, Himi T, et al.: "Prognostic factors and treatment outcome in non-Hodgkin's lymphoma of Waldeyer's ring." Acta Oncologica. 36. 413-420 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 原渕保明,今井章介,形浦昭克,大里外誉郎.: "特集 EBウイルスとヒトがん -最近の展望- リンパ腫とEBウイルス 鼻性T細胞リンパ腫." 日本臨床. 55. 394-399 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 原渕保明,形浦昭克: "進行性鼻壊疽(鼻性T細胞リンパ腫)." 耳鼻咽喉科診療Q&A.25. 448-1449ノ3 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 原渕保明.: "進行性鼻壊疽(鼻性T細胞リンパ腫)" 研修医のための耳鼻咽喉科・頭頚部外科.178-181 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Harabuchi Y, Imai S, Kataura A, Osato T, Kon S.: "Nasal T-cell lymphoma causally associated with Epstein-Barr virus.In.Epstein-Barr virus and human cancer" Gann Monograph on Cancer Research;. 45. 129-137 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Harabuchi Y,Imai S,Wakashima J,Hirao M,Kataura A,Osato T,Kon S.: "Nasal T-cell lymphoma causally associated with Epstein-Barr virus : Clinicopathologic, phenotypic, and genotypic studies." Cancer. 77. 2137-2149 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Harabuchi Y,Kataura A,Imai K.: "Circulating intercellular adhesion molecule-1 and its cellular expression in head and neck non-Hodgkin's lymphomas, including lethal midline granuloma." Ann Otol Rhinol Laryngol. 105. 634-642 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Harabuchi Y,Tsubota H,Ohguro S,Himi T,Asakura K,Kataura A,Ohuchi A,Hareyama M.: "Prognostic factors and treatment outcome in non-Hodgkin's lymphoma of Waldeyer's ring." Acta Oncologica. 36. 413-420 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Harabuchi Y,Imai S,Kataura A,Osato T,Kon S.: "Nasal T-cell lymphoma causally associated with Epstein-Barr virus. In : Osato T,Takada K,Tokunaga M,eds. Epstein-Barr virus and human cancer." Japan Scientific Societies Press, Tokyo, Gann Monograph on Cancer Research. 45. 129-137 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Harabuchi Y,Imai S,Wakashima J,et al.: "Nasal T-cell lymphoma causally associated with Epstein-Barr virus : Clinicopathologic,phenotypic,and genotypic studies." Cancer. 77. 2137-2149 (1996)

    • Related Report
      1998 Annual Research Report
  • [Publications] Harabuchi Y,Kataura A,Imai K.: "Circulating intercellular adhesion molecule-1 and its cellular expression in head and neck non-Hodgkin's lymphomas,including lethal midline granuloma." Ann Otol Rhinol Laryngol. 105. 634-642 (1996)

    • Related Report
      1998 Annual Research Report
  • [Publications] Harabuchi Y,Tsubota H,Ohguro S,Himi T,et al.: "Prognostic factors and treatment outcome in non-Hodgkin's lymphoma of Waldeyer's ring." Acta Oncologica. 36. 413-420 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 原渕保明,今井章介,形浦昭克,大里外誉郎.: "特集 EBウィルスとヒトがん -最近の展望- リンパ腫とEBウィルス 鼻性T細胞リンパ腫." 日本臨床. 55. 394-399 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 原渕保明,形浦昭克: "進行性鼻壊疽(鼻性T細胞リンパ腫)" 耳鼻咽喉科診療Q&A.25. 448-1449ノ3 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 原渕保明.: "進行性鼻壊疽(鼻性T細胞リンパ腫)" 研修医のための耳鼻咽喉科・頭頚部外科.178-181 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Harabuchi Y,Imai S,Kataura A,Osato T,Kon S.: "Nasal T-cell lymphoma causally associated with Epstein-Barr virus. In.Epstein-Barr virus and human cancer" Gann Monograph on Cancer Research ;. 45. 129-137 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 原渕保明,他: "リンパ腫とEBウイルス・鼻性T細胞リンパ腫" 日本臨床. 55. 394-399 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Harabuchi.Y,et al.: "Nasal T-cell lymphoma causall'y associated with Epstein-Barrviru" Gann Monograph on Cancer Research. 45. 129-137 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Harabuchi Y,et al: "Circulating intercellular adhesion molecule^<-1>(ICAM-1) and its cellular expression in head and neck non-Hodgkin'lymphoma" Annals Oto Rhino Laryngol. 105(8). 634-642 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Harabuchi Y,et al: "Nasal T-cell lymphoma causally associated with Epstein-Barrvirus : Clinicopathologic,phenotypic,and genotypic studies." Cancer. 77. 2137-2149 (1996)

    • Related Report
      1996 Annual Research Report

URL: 

Published: 1996-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi