| Project/Area Number |
08671989
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | TOHO UNIVERSITY |
|---|
Principal Investigator |
USUI Nobuo Toho University, 2^<nd> Department of Otorhinolaryngology, Professor, 医学部, 教授 (30057533)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HARA Toshiaki Toho University, 2^nd Depaetment of Otorhinolaryngology, Instructor, 医学部, 助手 (80266965)
OHKI Motfumi Toho University, 2^<nd> Department of Otorhinolaryngology, Assistant Professor, 医学部, 講師 (60185212)
|
|---|
| Project Period (FY) |
1996 – 1997
|
| Project Status |
Completed (Fiscal Year 1997)
|
| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1996: ¥1,800,000 (Direct Cost: ¥1,800,000)
|
|---|
| Keywords | Allergic Rhinitis / Nasal Blood Flow / Tissue oxigen pressure |
|---|
| Research Abstract |
Congestion and decongestion of the nasal mucosa are induced by dilatation and shrinkage of capacitance vessels. But the diameter of capacitance vesels is not always compatible with changes in nasal blood flow.
Our first study was that nasal voume and nasal blood flow were measured in normal subects and patients with allergic rhinitis. Nasal air volume was measured with acoustic rhinometry, and nasal blood flow was determined with the invetion of laser doppler floemeter. As a result, the changes in nasal air volume and nasal blood flow showed decreases after topical nasal decongestant. However it was no significant correlation between the rates of change for either nasal air volume or nasal blood flow. This result suggests that the vessels in the various parts of the nasal mucosa don't always respond in the same way.
On the other hand, tissue oxigen ppressure is correlated with blood flow. Recently, new tissue oxigen monitoring was invented and several authors reproted this method was useful to measure blood flow in tissues of brain or heart musssle. Then, tissue oxigen prrssure in nasal mucosa was measured at rest, after dongestant nasal spray and after methacoline nasal spray. The result showed that tissue oxigen pressure was decreased after decongestant nasal spray and incresed after methacoline nasal spray. This result suggest that nasal blood flow is influenced by alphastimulant and cholinergic factor. Therefore, in order to investigate the pathophysiology of nasal allergy, the analysis of blood circulation and the study of another chemotactic factors are required in detail.
|
