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Experimental Research on Revensibility of Noise Induced Hearing Impaivment

Research Project

Project/Area Number 08672001
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionUniversity of Occupational and Environmental Health

Principal Investigator

YOSHIDA Masatumi  University of Occupational and Environmental Health, Medical School, Otolaryngol Asociate Professor, 医学部, 助教授 (00182783)

Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1997: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsNoise exposure / solicylate / 2f_1-f_2 distortion product / Cochleon microphoncas / Otoacoustic emission / Electrical Stimuletion / Hearing impariment / outer hair cell / 2f1-f2歪成分
Research Abstract

Results and conclusions of the researches during the period from 1996 to 97 were as follows.
1. Suppression of the 2f1-f2 distortion product (DP) by the third tone was measured in cochlear microphonics (CM) and otoacoustic emissions (OAE). The suppression properties in the CM-DP and the DPOAE were similar to each other. This indicated that the both DP have a common generation mechanisms, and that the data on the CM-DP obtained from our animal experiments on acoustic overstimulation can be applied aptly to the DPOAE in daily clinic.
2. Acoustic responses were evoked by direct electrical simulation to the cochlea using a constant alternating current stimulator made in our laboratory. Measurement of the acoustic responses, electrically evoked otoacoustic emissions (EEOAEs) , in which stable responses could be obtained with simple and easy preparation, was considered a potential procedure for assessing the electro-mechanical transduction of the outer hair cells in vivo.
3. The EEOAEs were measured after acoustic overstimulation or administration of salicylate, both of which produced temporary threshold elevation of the compound action potential in similar magnitude to each other. The output of EEOAE was reduced by around 12dB after salicylate administration, although acoustic overstimulation resulted in little diminution in the EEOAE output. These data suggested that the temporary threshold elevations in hearing were caused by suppression of the electro-mechanical transduction of the outer hair cells in salicylate administration and of the mechano-electrical transduction in acoustic overstimulation.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] 吉田 雅文: "電気刺激により誘発される耳音響放射" 日本耳鼻咽喉科学会会報. 100・12. 1459-1464 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 藤村 和伸: "CM及び耳音響放射の2f_1-f_2歪成分に対する第3音の抑圧効果" 日本耳鼻咽喉科学会会報. 100・8. 8-845 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M Aoyagi: "Different effects norse and sclicylate and their interactions on the guninea pig cochlea." Eur Arch Otorhinc laiyngol.253・3. 429-434 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 吉田 雅文: "モルモット蝸牛内自発交流電位の外部音による抑圧" 日本耳鼻咽喉科学会会報. 99・4. 327-332 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M, Yoshida: "Physiolo,Basis of Occupational Health,Shirak K et al ed." SPB Acad Publ,Ainsterdam,The Nether lands, 278 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M Yoshida et al: "Otoacoustic emissions evoked by electrical stimulation" J Otolaryngol Jpn. 100. 1495-1464 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K Fujimura et al: "Suppression tuning characteristics of 2f1-f2 distortion product in cochlear microphonics and otoacoustic" J Otolaryngol Jpn. 100. 839-845 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M Aoyagi et al: "Different effects of noise and salicylate and their interactions on the guinea gig cochlea." Eur Arch Otorhinolaryngol. 253. 429-434 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M Yoshida et al: "Suppression of spontaneous AC potentials in guinea pig cochlea by external tones" J Otolaryngol Jpn. 99. 327-332 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M Yoshida et al: Mechanisms underlying noise induced temporal threshold shift in hearing.in physiological basis of occupational health, K shiraki et al ed.SPB Acad Publ, Amsterdam, 278 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 吉田雅文: "電気刺激により誘発される耳音響放射" 日本耳鼻咽喉科学会会報. 100・12. 1459-1464 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 藤村和伸: "CM及び耳音響放射の2f_1-f_2歪成分に対する第3音の抑圧効果" 日本耳鼻咽喉科学会会報. 100・8. 839-845 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Aoyagi: "Different effects of noise and Salicylate and ther interactions on the grinea pig cochlea." Eur.Arch Oporhinolaryrgol. 253・3. 429-434 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 吉田雅文: "モルモット蝸牛内自発交流電位の外部音による抑圧" 日本耳鼻咽喉科学会会報. 99・4. 327-332 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Yoshida: "Physiol Basis of Oceapatinal Health.Shiraki K et al ed." SPB Acad publ.Ainsterdam.The Nether lands, 278 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 吉田雅文他: "モルモット蝸牛自発交流電位の外部音による抑圧" 日本耳鼻咽喉科学会会報. 99・2. 327-332 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 牧嶋和見,吉田雅文 他: "高周波数域オ-ジオメータの開発とその臨床応用" Audiology Japan. 39・2. 158-163 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 吉田雅文: "聴こえ(音受容)のメカニズム" 総合リハビリテーション. 24・10. 1003-1005 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Aoyagi,M.Yoshida et al: "Different effects of noise and salicylete and their intevaction on the guirea pig cochlea" Europian Archives of Otorhino laryngology. 253・. 429-434 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 是永克実,牧嶋和見,吉田雅文他: "垂直性OKNとOKANの方向非対称性に関する実験的研究" 日本耳鼻咽喉科学会会報. 99・8. 1085-1996 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Yoshida et al: "Physiological Basis of Occupational Hearth, Ed by K.Shirck" SPB Academic Publishing,Amsterdam, 273 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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