| Project/Area Number |
08672003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
KADO Masanori (1997) Asahikawa Medical College, 医学部, 講師 (90169532)
秋葉 純 (1996) 旭川医科大学, 医学部, 講師 (70150985)
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| Co-Investigator(Kenkyū-buntansha) |
HIKICHI Taiichi 旭川医科大学, 医学部, 助手 (50198983)
門 正則 旭川医科大学, 医学部, 講師 (90169532)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | PVD / Plasmin / Sulfur-hexa-fluoride / 網膜血管新生 / 硝子体 / 網膜新生血管 |
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| Research Abstract |
Our model was designed to investigate if an injection of plasmin and sulfur-hexa-fluoride (SF6) can induce posterior vitreous detachment (PVD) without vitrectomy. One eye each of 15 New Zealand white rabbits was assigned to one of three groups. Eyes in group I received a vitreous injection of i unit of human plasmin (0.1 mL reconstituted in balanced salt solution) and 0.5 mL of SF6 ; eyes in group II received a vitreous injection of plasmin alone ; eyes in group III received a vitreous injection of SF6 alone. Seven days after injection, all animals were monitored electroretinographically then sacrificed, and the eyes were enucleated. After fixation, scanning electron microscopy was performed. In group I eyes, the retinal surface was smooth except for the vitreous base, which showed complete separation of the vitreous cortex from the retina, indicating PVD development. In group II and III eyes, sparse collagen fibers remained on the retinal surface. Vitreous injection of piasmin combined with SF6 can induce PVD without vitrectomy.
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