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Histopathologic and Electrophysiologic Study of Neonatal Normal Mouse Retina Transplanted into Retinal Dystrophic Mice

Research Project

Project/Area Number 08672012
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionToho University

Principal Investigator

YAMAMOTO Shuichi  Toho University, School of Medicine, Associate Professor, 医学部, 助教授 (20230550)

Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsRetinal Transplantation / Retinal Dystrophy / Transgenic Mouse / Electroretinogram / トランジェニックマウス
Research Abstract

1) Transplanted neonatal mouse retina survived without immune suppression for a long period after the transplantation surgery.
2) However, management of the photoreceptor polarity was very difficult, and in only a few cases, photoreceptor outer segments developed with proper direction.
3) Several different methods of transplantation have been tried, however, any better surgical outcomes were not obtained, and further studies had to be postponed.
4) Electroretinograms were examined in patients with different retinal diseases to study retinal function, in order to compare With that of dystrophic mice.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Komiyama M: "Undetectable S-cone electroretinogram b-wave in congeutal stationary night blindness" British Journal of Ophthalnology. 80. 637-639 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamamoto S: "Selective reduction of the S-cone electroretinogram in diabetes" British Journal of Ophthalnology. 80. 973-975 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamamoto S: "Cone electroretinogram to chromtic stimuli in myopic eyes" Vision Research. 37. 2157-2159 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamamoto S: "Normal S cone elecroretinogram b-wave in Oguchi's disease" British Journal of Ophthalnology. 81. 1043-1045 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kamiyama M,Yamamoto S,Nitta K,Hayasaka S: "Undetectable S-cone electroretiogram b-wave in complete congenital stationary night blindness" British Journal of Ophthalmology. 80. 637-639 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamamoto S,Kamiyama M,Nitta K,Yamada T,Hayasaka S: "Selective reduction of the S-cone electroretiogram in diabetes" British Journal of Ophthalmology. 80. 973-975 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamamoto S,Nitta K,Kamiyama M: "Cone electroretinogram to chromatic stimuli in myopic eyes." Vision Research. 37. 2157-2159 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamamoto S,Hayashi M,Takeuchi S,Shirao Y,Kita K,Kawasaki K: "Normal S cone electroretinogram b-wave in Oguchi's disease." British Journal of Ophthalmology. 81. 1043-1045 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamamoto S: "Cone electroretinogram to chromaticstimuli in myopic eyes." Vision Research. 37. 2157-2159 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yamamoto S: "Normal S・cone electro retino gram b-wave in Oguchi's disease" British Journal of Ophtholmology. 81. 1043-1045 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kamiyama M: "Undetectable S-cone electroretinogorm b-wave in complete congenital stationary night blindness" British Journal of Ophthalmology. 80. 637-639 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yamamoto S: "Selective reduction of the S-cone electroretinogram in diabetes" British Journal of Ophthalmology. 80. 973-975 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yamamoto S: "Cone electro retinogram to chromatic stimuli in mycpic eyes" Vision Research. (in print).

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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