Effects of FTY720 on experimental autoimmune uveoretinitis (EAU) and experimental melanin-protein-induced uveitis (EMIU)
| Project/Area Number |
08672046
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | KURUME UNIVERSITY |
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Principal Investigator |
HIKITA Naofumi Kurume University, Ophthalmology, Associate professor, 医学部, 助教授 (80173152)
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| Co-Investigator(Kenkyū-buntansha) |
KUROSE Shinichi Kurume University, Ophthalmology, Clinical fellow, 医学部, 助手 (40225298)
IKEDA Eiko Kurume University, Ophthalmology, Clinical fellow, 医学部, 助手 (70222875)
WATANABE Shiho Kurume University, Ophthalmology, Clinical fellow, 医学部, 助手
YOSHIMURA Koichi Kurume University, Ophthalmology, Lecture, 医学部, 講師 (30240352)
MOCHIZUKI Manabu Kurume University, Ophthalmology, Professor, 医学部, 教授 (10010464)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Immumosuppressant / FTY720 / EAU / EMIU / uveitis / animal / systemic treatment / topical treatment / 実験的自己免疫性ぶどう膜炎(EAU) / メラニン起因性ぶどう膜炎(EMIU) / EMIU / Uveitis / rat |
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| Research Abstract |
The effects of FTY720 both on EAU and EMIU in Lewis rat were studied in this research. Systemic and topical administration of FTY720 suppressed the development of EAU and EMIU,and also showed therapeutic efect even after the development of disease. Thus, FTY720 may become one of the therapeutic alternatives for refractory uveitis in humans.
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Report
(3 results)
Research Products
(2 results)
