| Project/Area Number |
08672057
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
小児外科
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| Research Institution | KOBE UNIVERSITY,SCHOOL OF MEDICINE |
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Principal Investigator |
HISANO Katsuya KOBE UNIVERSITY,SCHOOL OF MEDICINE.ASSOCIATE PROFESSOR, 医学部, 助教授 (30135800)
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| Co-Investigator(Kenkyū-buntansha) |
YASUHUKU Masao KOBE UNIVERSITY,SCHOOL OF MEDICINE,CLINICAL FELLOW, 医学部・附属病院, 医員
UETANI Yosiyuki KOBE UNIVERSITY,SCHOOL OF MEDICINE,ASSOCIATE PROFESSOR, 医学部, 助教授 (40168620)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1997: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | FETAL A-V ECMO / ARTIFICIAL PLACENTA / LUNG MATURATION / 肺成熟 / artificial placenta / 胎児肺成熟 / サーファクタント |
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| Research Abstract |
The goat fetuses at about 125 days gestation were placed in the fetal ECMO system. The mean duration of A-V ECMO was 138 hours. The surfactant and electrolytes of the tracheal fluid were analyzed in pre-ECMO and during ECMO.The surfactant of lung tissue, and lung weight were analized in pre-ECMO and afte ECMO.Plasma cortisol and T3 levels were also assayd as hormonal factors that affected lung maturation in pre-ECMO and during ECMO.The phospholipid, phosphatidylcholine and lecithinsphingomeyelin ratio of the tracheal fluid on day 5 during ECMO were elevated above pre-ECMO.The phosphatidylcholine and disturacted phosphatidylcholine of the lung tissue after ECMO were 72.3mg/g and 19.2mg/g, which were significantly higher than pre-ECMO.The wet and dry lung weights after ECMO was 87.8g and 6.3g, which were significantly higher than pre-ECMO.Plasma control levels and T3 levels during ECMO were significantly higher than pre-ECMO.Electron microscopy demonstrated a higher increase of mature type II cells in the lung after ECMO than pre-ECMO.
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