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Micro vascular architecture and bone formation after Guided Bone Regeneration

Research Project

Project/Area Number 08672105
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionKanagawa Dental College

Principal Investigator

MATSUO Masato  Kanagawa Dental College, Oral Anatomy, Assistant professor, 歯学部, 講師 (30190416)

Co-Investigator(Kenkyū-buntansha) KISHI Yoshiaki  Kanagawa Dental College, Oral Anatomy, Associate professor, 歯学部, 助教授 (60084779)
TAKAHASHI Kazuto  Kanagawa Dental College, Oral Anatomy, professor, 歯学部, 教授 (00084707)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
KeywordsGBR / SEM / resin cast / microcirculation / GBR / PTFE
Research Abstract

Guided bone regeneration (GBR) is a periodontal treatment to restore the loss of alveolar bone. In the present study, nonresorbable and resorbable membranes were applied to the extraction socket / artificial bone cavity and vascular resin cast model was examined under scanning electron microscopy (SEM).
In the observation of nonresorbable membrane, bone aposition was observed upward and sideways beyond the alveolar crest after 14 days postoperation. Regenerated blood vessels were distributed in the newly formed porous bone.30 days following surgery, In the center portion of the extraction socket, newly-formed vascular network and regenerated bone were observed. A flat vascular network from the periosteum was observed on the GBR membrane. 60 days following surgery, Regenerated bone and a vascular network of the bone marrow were observed.
In the observation of resorvable membrane, 90 days after the operation, the membrane, which showed evidence of being resorbed, was found between the superficial vascular network of the oral mucosa and the regenerated alveolar bone. Blood vessels from the periosteum increased in caliber as they passed through the resorbed part of the membrane.
These results indicate that regardless of what type of membrane is used, it only acts as a barrier preventing the oral mucosa from migrating apically to the socket, thereby creating an environment that promotes the proliferation of cells in the socket.
From the viewpoint of the microcirculation, the level reached by blood vessels arising from the periosteum might play an important role in determining the final height of regenerated alveolar bone.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Matsuo M: "Microvascular architecture of alveolar bone after guided bone regeneration with a resorbable membrane." Jpn J Oral Biol. 40. 656-661 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsuo M: "The study of microvascular changes of alveolar bone after guided bone regeneration (GBR) using PTFE membrane" Microcirculation annual. 15. 71-72 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 松尾雅斗: "Guided Bone Regeneration後の周囲組織における骨再生と微細血管構築の変化について。" 神奈川歯学. 33. (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsuo M,Kishi Y,Takahashi K et al.: "Microvascular architecture of alveolar bone after guided bone regeneration with a resorbable membrane." Jpn J Oral Biol.40. 656-661 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsuo M,et al.: "Morphological changes in alveolar bone regeneration and vascularization during healing of extraction soccket using PTFE membrane." KANAGAWASHIGAKU. 33. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takahashi K,Kishi Y,Matsuo M: "Micro circulation surrounding dental implant tissues" HYOUMEN GIJUTU. 49. 696-701 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoshiaki Kishi, Masato Matsuo, et al.: "Microvasucular architecture in two distinct gingival regions divided by an accumulation of dental calculus." Jpn J Oral Biol. 40. 196-200 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsuo M,Kishi Y,Takahashi K et al.: "The study of microvascular changes of alveolar bone after guided bone regeneration (GBR) using PTFE membrane." Microcirculation annual. 15. 71-72 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.MATSUO,Y.KISHI,K.TAKAHASHI.et al.: "Microvascular regeneration after the placement of dental implants." 3rd Asian Congress for MICROCIRCULATION Bangkok, Thailand. 301-304 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Matsuo Y kishiK Takahashi, et al.: "Microvascular architecture and osseous healing after the placement of denta limplants" Sixth World Congress for Microcircuolation Munich Germany. 533-536 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsuo M: "Microvascular architecture of alveolar bone after guided bone regeneration with a resorbable membrane." Jpn J Oral Biol. 40. 656-661 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Matsuo M: "The study of microvascular changes of alveolar bone after guided bone regenration(GBR)using PTFE membrane" Microcirculation annual. 15. 71-72 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 高橋和人: "歯周組織の微小循環 第6回歯根膜の不思議を探る2.抜歯・再植実験で見えてきた歯根膜の厚さセンサーの所在" 歯科技工. 26. 647-653 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 高橋和人: "歯周組織の微小循環 第8回血管の壊れ方1.咬合性外傷はなぜ起こる" 歯科技工. 26. 903-909 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 高橋和人: "歯周組織の微小循環 第10回 顎骨の修復 咬合性外傷は治癒するか" 歯科技工. 26. 1151-1157 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Matsuo: "Microvascular architecture and osseous healing after the placement of denta limplants" Sixth World Congress for Microcircuolation. 533-536 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 高橋和人: "骨膜の処理" 日本歯科評論. 4. 642-643 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 岸 好彰: "インプラントでも天然歯肉と同じ血管網が再構築される" ザ・クインテッセンス. 15. 23-25 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 松尾雅斗: "インプラント周囲組織(peri implant tissue)に炎症防御機構は存在するか?-歯周組織およびインプラント周囲組織の微小循環について-" 歯界展望. 89. 234-235 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 高橋和人: "治癒の病理.臨床編第3巻" 医歯薬出版, 29 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 岸 好彰: "治癒の病理.臨床編第4巻" 医歯薬出版, 14 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Masato MATSUO: "The vascular changes of regenerating process after implantation of HAP and TCP" Microcirculation Annual. 11. 171-172 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 岸好彰: "GBR法による骨の再構築と血管網の関わり" クインテッセンス出版 クインテッセンスyearbook. 23-28 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Masato MATSUO: "Microvascular architecture and osseous healing after the placement of denta limplants." 6th World Congress for Microcircuolation,Munich,. 533-536 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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