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THE ROLES OF CENTRAL HISTAMINERGIC SYSTEM IN ABNORMAL JAW MOVEMENTS IN RATS.

Research Project

Project/Area Number 08672116
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionDEPARTMENT OF PHARMACOLOGY,TOHOKU UNIVERSITY SCHOOL OF DENTISTRY

Principal Investigator

ONODERA Kenji  DEPARTMENT OF PHARMACOLOGY,TOHOKU UNIVERSITY SCHOOL OF DENTISTRY,ASSOCIATED PROFESSOR, 歯学部, 講師 (40133988)

Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordsorofacial movements / abnormal jaw movements / rats / histaminergic neuron / haloperidol / licking / biting / dyskinesia / ヒスタミン神経 / 運動機能 / ヒスタミン / ドパミン / メタンフェタミン / 線条体 / マイクロダイアリシス / 抗ヒスタミン薬
Research Abstract

Methamphetamine, a psychostimulant, produced abnormal jaw movements such as licking and biting, which behavior is regarded as an animal model of dyskinesia in human. The intracerebroventricular administration of histamine produces anorexia and arousal states in cats and rats. However, the possible involvement of histaminergic system in the actions of methamphetamine is still unclear. Therefore, we examined the effects of histaminergic agents on methamphetamine-induced abnormal jaw movements such as licking and biting, and the effects of dopaminergic agents including methamphetamine on the histaminergic system using microdialysis method in rat brain. From the findings obtained here, it is suggest that central histaminergic system has an inhibitory role in methamphetamine-induced abnormal jaw movements such as licking and biting. Interestingly, when abnormal jaw movements was observed in methamphetamine-treated rats, histamine release of striatum was significantly increased in compared with the saline-treated rats. Pretreatments with sulpiride (10mg/kg)and haloperidol (0.5 mg/kg), dopamine D2 antagonists, blocked the methamphetamine-induced elevations in histamine release in the rat striatum, whereas SCH23390 (0.1 mg/kg), a dopamine D1 receptor antagonist, could not. In this study, we could clarify the inhibitory role of histaminergic system through dopamine D2-receptors in abnormal jaw movements such as licking and biting.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Onodera K., Itoh C., Sato M.and Watanabe: "Motor behavioral fuuction for histamine-dopamin interaction in brain" Inflammation Research. (印刷中). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ito C., Onodera K., Atanabe T., &Sato M.: "Effects of Histamin Agents on methamphtamin-lnduced stereotyped Behavior and Bhavioral Sensitization in rats." Physliop haria cology. 130. 362-367 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ito C., Onodera K., Yamamoodani A Watanabe T&Sato M: "The effect of methample tamcire on ficitamine release in the rat pc thelanus" Pscliet Clin Nearoscrercses. 51. 79-81 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Onodera, K., Itoh, C., Sato, M., Watanabe, T.: "Motor behavioral function for histamine-dopamine interaction in brain." Inflammation Res. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ito, C., Onodera, K., Watanabe, T., Sato, M.: "Effects of methamphetamine-induced stereotyped behavior and behavioral sensitization in rats." Psychopharmacology.130. 362-367 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ito, C., Onodera, K., Yamatodani, A., Watanabe, T., Sato, M.: "The effect of methamphetamine on histamine release in the rat hypothalamus." Psychiat.Clin.Neurosciences.51. 79-81 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ito, C., Onodera, K., Sakurai, E., Sato, M., Watanabe, T.: "Effects of dopamine antagonists on neuronal histamine release in the striatum of rats subjected to acute and chronic treatments with methamphetamine." J.Pharmacol.Exp.Ther.279. 271-276 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ito, C., Onodera, K., Sakurai, E., Sato, M., Watanabe, T.: "The effect of methamphetamine on histamine level and histidine decarboxylase activity in the rat brain." Brain Res.734 (1-2). 98-102 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ito, C., Onodera, K., Sakurai, E., Sato, M., Watanabe, T.: "The Changes of histamine H3 receptors in methamphetamine-treated rat brain." Meth Find Exp Clin Pharmacol. 18 (Suppl.A). 133-138 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Onodera, K., Watanabe, T.: Histamine influences on general behavior : Possible roles of histamine in motor behavior.In : The Neurobiology of Histamine. (Prell, G.D.ed.). Humana Press, New York, in press,

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ito, C., Sato, M., Onodera, K., Watanabe, T.: The role of the brain neuron system in methamphetamine-induced behavioral sensitization in rats. In : Cellular and Molecular Mechanisms of Drugs of Abuse. Cocaine, Ibogaine, and Substituted amphetamines. (Eds.Ali, S,F., Takahashi Y,). The New York Academy of Sciences.New York, 353-60 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Onodera K, Itoh C, Sato M, and Watanabe T: "Motor behavioral function for histamine-dopamine interaction in brain" Inflammation Research. (印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito C., Onodera K., Watanabe T., Sato M.: "Effects methanplataunx induccd stereotyped belavion and behavioral sengitization in rats." Psyclapharmacology. 130. 362-367 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito C., Onodera K, Yamatodani A, Watanabe T & Sato M: "The effect of methamphetamine on bitamine reloaise in thent hgprthelamus" Psychiat.Clin Neurosciences. 51. 79-81 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito C, Onodera K, Sakurai E, Sato M. & Watanabe T: "Effects of dopamine antogonists on micenal histamine relase in the stiatan of rats subjected to acate and chronic" treatments with mutlowphotamine J.Pharmacol.Exp.Ther.279. 271-276 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito C., Onodera K, Sakurai E, Sato M & Watanabe T: "The effect of methamphetamine on luxtamine livels and bistidius decarboxylase activity in the rat brain." Brain Res. 734. 98-102 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito C, Onodera T, Sakurai E, Sato M & Watanabe T: "The changes of histamine H3 receptors in mcthonphutamine-treated lat brain." Moth Find Exp Clin Phamtacol. 18(SupA). 133-138 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Onodera K & Watanabe T: "Histamine inflaenco on general behavior : Possible 10lcs of histamine interaction" Prell.G.D.The Nearobiology of Histamine,Humana Press(印刷中), (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito C, Sato M, Onodera K, Watanabe T: "in rats. Cellular and Melecular Mechanisms of Prags of Abuse,Cocaine,Ibogaine,and substituted Ampletamines. (Eds) Ali SF & Takahash Y." The role of the brain histaminergac reuron system in nethaxplatamine-induced leiriyoral sonsitization, 8 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Chihiro Ito: "The effect of methamphetamine on histamille level and luitidine decarboxylaseactivity in the rat brain." Brain Research. 734. 98-102 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] chihiro Ito: "Effects of Lopamine antagonists on necronel lirtamine release in the striatem of rats subjected to a cuts mdduuiuc trechwat with mathamphetative" Journal of Pharmacalogy and Expuwand Thevepeutics. 279. 271-276 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] chihiro Ito: "Annals of the New York Academy of Scieuces (vol. 801)" New York Academy of Scieuces, 7/452 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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