| Project/Area Number |
08672168
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
病態科学系歯学(含放射線系歯学)
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| Research Institution | Tokyo Women's Medical College |
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Principal Investigator |
ANDO Tomohiro Tokyo Women's Medical College, Lecturer, 医学部, 講師 (80151207)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOO Emiko Tokyo Women's Medical College, Lecturer, 医学部, 講師 (70114791)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Heat shock protein / focal infection / Pustulosis palmaris et plantoris / 歯周病 / 口腔粘膜疾患 / 掌蹠膿胞症 |
|---|
| Research Abstract |
Heat shock proteins (HSP) are highly conserved immunogenic molecules that are induced by a variety of stresses. Structural homology between microbial and human HSP has been postulated to be a basis for autoimmunization in chronic inflammatory diseases. We estimated by ELISA titration the antibody levels to GloEL/GroES,Mycobacterium bovis BCG HSP65 and recombinant human HSP60 in sera of patients with palmoplantar pustulosis (PPP). In comparison with healthy controls (n=22,0.218(]SY.+-。[)0.176), serum anti GroEL/GroES lgG antibodies were elevated in PPP (n=43, 0.342(]SY.+-。[)0.246, p<0.05), but anti M.bovis HSP65 and r-human HSP60 antibodies were not significant difference. There were a correlation between levels of anti GroEL/GroES antibody and r-human HSP60. In PPP, as a focal infectious disease, bacterial HSP might be a antigen, but human HSP60 not be autoantibody.
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