| Co-Investigator(Kenkyū-buntansha) |
IKE Hiromi Osaka Dental University, Faculty of Dentistry, Assistant, 歯学部, 助手 (30222855)
TODA Isumi Osaka Dental University, Faculty of Dentistry, Assistant, 歯学部, 助手 (20197891)
TAKEMURA Akimichi Osaka Dental University, Faculty of Dentistry, Recturer, 歯学部, 講師 (00155045)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Research Abstract |
It is necessary to control the absorption of alveolar bone after tooth extraction for prosthodontic treatment. The guided bone regeneration (GBR) method has been reported on the application to the extracted tooth socket, and how to use an absorbable membrane to reduce the patient's pain. This study investigated the contribution of human dura mater to microvascularization and osteogenetic changes in extracted sockets by SEM observation.
Materials and Methods
The upper incisors in Macaca fuscota were bilaterally extracted, and the human dura mater was applied and covered one of the sockets. The other side was the control. After application, the gingivoperiosteal flap was carefully sutured. At 1,2,4,6 and 8 weeks after postoperatively, microvascular casts prepared by the plastic injection method were examined by SEM.
At 1 week, both site sockets were filled with the newly-formed sinusoidal capillaries which elongated from the socket wall ; no bone formation was observed. At 2 weeks in the experimental site, the newly-formed microvascularization was denser than the control. At 4 weeks, the bottom half of the both site sockets were filled with newly-formed bone trabeculae, but in the experimental site, the new bone trabeculae was denser. At 6 weeks, the both site sockets were filled with new bone trabeculae. However, we observed a shallow concave at the top of each socket. At 8 weeks, in the experimental site, the extracted socket was filled with the new bone trabeculae, and the edge of the socket was flat. While in the control site, the shallow concave was still observable.
We conclude that the human dura mater contributes to the osseous healing of the socket left by extraction and prevents the absorption of alveolar bone.
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