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Investigation of malignant potential of oral leukoplakia by a diagnostic imaging system

Research Project

Project/Area Number 08672276
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

SATHO Tohru  Hokkaido Univ., School of Dentistry, Instructor, 歯学部, 助手 (10178494)

Co-Investigator(Kenkyū-buntansha) SATOH Akira  Hokkaido Univ. Dental Hospital, Instructor, 歯学部附属病院, 助手 (90271684)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsoral leukoplakia / malignant potential / flow cytometry / DNAploidy / cell cycle / フローサイトメトリー / コンピューター解析
Research Abstract

Flow cytometric analysis of cell cycle fractions and DNA ploidy was performed on 39 biopsy specimens of oral leukoplakia. The aneuploidy rate of these leukoplakias was 9/39 (23%) and the mean DNA index of the aneuploid lesions was 1.34. The aneuploidy rate was significantly higher in severely dysplastic lesions (8/17) than in mildly dysplastic (1/15, p<0.02) and non-dysplastic (0/7, p<0.05) lesions. No significant differences in the percentages of each cell cycle fraction were seen between the diploid and the aneuploid leukoplakias. However, the S phase fraction of the severely dysplastic lesions (23.0%) among the diploid leukoplakias was higher than those of the mildly dysplastic (12.4%) and the non-dysplastic (15.5%) lesions, and the difference between the severely dysplastic and the mildly dysplastic lesions was statistically significant (p<0.001). These results suggest that flow cytometric analysis of cell cycle fractions and DNA ploidy might offer additional information for assessing the malignant potential of oral leukoplakias.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] T.Saito他: "Flow cytometric analysis of cell cycle fractions in oral leukoplakia"Int J Oral Maxillofac Surg. 27. 217-221 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Saito他: "High malignant transformation rate of widespread multiple oral leukoplakias"Oral Dis. (印刷中). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Saito, T., Mizuno, S., Notani, K., Fukuda, H.,Kobayashi, I., Shindoh, M., Kohgo, T.: "Flow cytometric analysis of cell cyclefractions in oral leukoplakia"Int J Oral Maxillofac Surg. 27. 217-221 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Saito, T., Sugiura, C., Hirai, A, Notani, K, Totsuka, Y.Shindoh,M,Kohgo,T.,Fukuda,H.: "High malignant transformation rate of widespread multiple oral leukoplakias"Oral Dis 1999. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tohru.Saito: "Flow cytometric amalysis of cell cycle fractions in oral leukoplakia" Int.J.Oral Maxillo Pac.Surg.(印刷中).

    • Related Report
      1997 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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