Investigation of malignant potential of oral leukoplakia by a diagnostic imaging system
| Project/Area Number |
08672276
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
SATHO Tohru Hokkaido Univ., School of Dentistry, Instructor, 歯学部, 助手 (10178494)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Akira Hokkaido Univ. Dental Hospital, Instructor, 歯学部附属病院, 助手 (90271684)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | oral leukoplakia / malignant potential / flow cytometry / DNAploidy / cell cycle / フローサイトメトリー / コンピューター解析 |
|---|
| Research Abstract |
Flow cytometric analysis of cell cycle fractions and DNA ploidy was performed on 39 biopsy specimens of oral leukoplakia. The aneuploidy rate of these leukoplakias was 9/39 (23%) and the mean DNA index of the aneuploid lesions was 1.34. The aneuploidy rate was significantly higher in severely dysplastic lesions (8/17) than in mildly dysplastic (1/15, p<0.02) and non-dysplastic (0/7, p<0.05) lesions. No significant differences in the percentages of each cell cycle fraction were seen between the diploid and the aneuploid leukoplakias. However, the S phase fraction of the severely dysplastic lesions (23.0%) among the diploid leukoplakias was higher than those of the mildly dysplastic (12.4%) and the non-dysplastic (15.5%) lesions, and the difference between the severely dysplastic and the mildly dysplastic lesions was statistically significant (p<0.001). These results suggest that flow cytometric analysis of cell cycle fractions and DNA ploidy might offer additional information for assessing the malignant potential of oral leukoplakias.
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Report
(3 results)
Research Products
(5 results)
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[Publications] Saito, T., Mizuno, S., Notani, K., Fukuda, H.,Kobayashi, I., Shindoh, M., Kohgo, T.: "Flow cytometric analysis of cell cyclefractions in oral leukoplakia"Int J Oral Maxillofac Surg. 27. 217-221 (1998)
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[Publications] Saito, T., Sugiura, C., Hirai, A, Notani, K, Totsuka, Y.Shindoh,M,Kohgo,T.,Fukuda,H.: "High malignant transformation rate of widespread multiple oral leukoplakias"Oral Dis 1999. in press.
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