Clinical signs and synovial fluid analysis in the temporomandibular joint of mandibular prognathism patients

• Project/Area Number: 08672319
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Saga Medical School
• Principal Investigator: GOTO Masaaki Saga Medical School, Department of Oral and Maxillofacial Surgery, Associate professor, 医学部, 助教授 (10145211)
• Co-Investigator(Kenkyū-buntansha): KUBOTA Eiro Kanagawa Dental College, Second Department of Oral and Maxillofacial Surgery, Pr, 歯学部, 教授 (50170030) ; NOGUCHI Nobuhiro Saga Medical School, Department of Oral and Maxillofacial Surgery, Resident, 医学部, 助手 (40284658) ; TOYOTA Jun-Ichiro Saga Medical School, Department of Oral and Maxillofacial Surgery, Resident, 医学部, 助手 (80281202) ; KATSUKI Takeshi Saga Medical School, Department of Oral and Maxillofacial Surgery, Professor, 医学部, 教授 (70038868)
• Project Period (FY): 1996 – 1997
• Project Status: Completed (Fiscal Year 1997)
• Budget Amount: ¥2,100,000 (Direct Cost: ¥2,100,000); Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000); Fiscal Year 1996: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: Madnibular prognathism / Jam movement / Synovial fluid analysis

Research Abstract

The purpose of this study is to tolally evaluate temporomandibular joint (TMJ) function.of mandibular prognathism patients by synovial fluid analysis, radiological examinations, and computerized jaw movement analysis.
Synovial fluid (SF) from TMJs with asymptomatic mandibular prognathism patients showed significantly lower levels (76.7(]SY.+-。[)95.3 pg/100 ug of SF protein) of IL-1 beta than TMF internal derangement (ID) patients (330.1(]SY.+-。[)347.7 pg/100 ug of SF protein). SF IL-6 and IL-8 levels tended to be lower than those of ID.No deformities of TMJ components wererevealed in asymptomatic TMJs of all mandibular prognathism patients. Computerized jaw movement analysis system showed no emergence of TMJ cliking and/or crepitation after orthgnatic surgery in all saymtomatic TMJs preoperatively.
In conclusion, SF of inflammatory mediators tended to be lower levels in the asymtomatic TMJs of mandibular prognathism with malocclsion than ID TMJs

Research Products

• [Publications] Kubota E et al: "Synovial fluid cytokines and proteinases as markers of temporomandibular joint disease" J Oral Maxillofac Surg. 56. 192-198 (1998)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Imamura H.et al: "IL-6 and IL-8 levels in synovial fluid correlate with osteoarthritis in the temporomandibular joint" Int J Oral Maxillofac Surg. (1998)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Eiro Kubota, Takao Kubota, Jun Matsumoto, Takanori Shibata, and Ken-Ichiro Murakami: "Synovial fluid cykokines and proteinases as markers of temporomandibular joint disease" J Oral Maxillofac Surg. 56. 192-198 (1998)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Kubota E et al: "Synovial fluid cytokines and proteinases as markers of temporomandibular joint disease" J Oral Maxillofac Surg. 56(1). 192-198 (1998)
• [Publications] Imamura H.et al: "IL-6 and IL-8 levels in synovial fluid correlate with osteoarthritis in the temporomandibular joint" Int J Oral Maxillofac Surg. (1998)