| Project/Area Number |
08672447
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | School of Pharmacy, Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
HANZAWA Yuji Tokyo University of Pharmacy and Life Science, School of Pharmacy, Associate Professor, 薬学部, 助教授 (10096688)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | Early transition metal / Zirconocene-butene complex / Catalytic reaction / Diastereoselective synthesis / Regioselective reaction / Asymmetric synthesis / ハイドロジルコネーション / ジルコノセン-(1-ブテン)錯体 / エポキシオレフィン / 不斉触媒反応 / 環変換反応 / Schwartz試薬 / ビニルエポキシド / ビニルシクロアルカン / ジアステレオ選択性 / ジルコノセン等価体 / Z-アリルジルコノセン |
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| Research Abstract |
In our ongoing research project on asymmetric catalytic reactions using low-valent zirconocene complex, we have exploited enormous possibilities of low-valent zirconium complex, zirconocene-butene complex, for organic synthesis. During the past term of the project we established several new zirconocene-butene complex-mediated synthetic procedures which must be elaborated to be catalytic and asymmetric. At present we could developed a new zirconocene-butene complex catalyzed ring opening reactions of vinyl cyclopropane derivatives whose stoichiometric reactions have been applied to stereocontrolled syntheses of steroidal side chains. Although the asymmetric version of these reaction has not been succeeded yet, we are currently continueing the research to find the most effective chiral ligand for zirconium metal complex.
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