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Studies on anti-dementia effects of Kampo medicines and their active ingredients

Research Project

Project/Area Number 08672546
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionThe Kitasato Institute

Principal Investigator

YAMADA Haruki  Oriental Medicine Reseach Center, Research Director, 東洋医学総合研究所・基礎研究部, 部長 (60096691)

Co-Investigator(Kenkyū-buntansha) YABE Takeshi  Oriental Medicine Reseach Center, Researcher, 東洋医学総合研究所・基礎研究部, 研究員 (40239835)
KIYOHARA Hiroaki  Oriental Medicine Reseach Center, Chief Researcher, 東洋医学総合研究所・基礎研究部, 室長 (70161601)
TORIZUKA Kazuo  Oriental Medicine Reseach Center, Research Vice-Director, 東洋医学総合研究所・臨床研究部, 副部長 (60135035)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsAlzheimer Disease / Kami-untan-to / ChAT / NGF / Polygalae Radix / 遠志 / アルツハイマー型痴呆
Research Abstract

In order to findeffective Kampo formulas for dementia due to cholinergic deficits, about 60 kinds of the formulas were screened effect on choline acetyltransferase (ChAT) activity in rat septal cultlured cell. Of these Kampo formulas, only one formula, named Kami-untan-to (KUT ; Jia-weiwen-dan-tang) showed the remarkable induction of ChAT activity in the cultured septal cells. When KUT was orally administrated to the ibotenic aacid-induced basel forebrain lesioned rats and aged rats, mean latency was significantly increased on passive avoidance test and ChAT activity in cerebral cortex was also increased. KUT increased nerve growth factor (NGF) mRNA levels in vivo and in vitro. Intracellular singal transduction and gene expression associated with the action of KUT with the activation of cAMP-PKA pathways and the induction of c-for mRNA may important roles for an enhancing effect of KUT on NGF secretion in the cells.
In order to idenatify the essential component herbs in KUT,extracts of individual component herbs in KUT and KUT minus one component herb were preparaed and their effects on the ChAT activity and NGF secretion were examined. The results suggested that constituents containing cinnamoly moiety in Polygalae Radix-extract may relatae to pharmacological activities of KUT on ChAT activity and NGF secretion.
In conclusion, present results indicated that KUT is a neurotrophic-like agents which is effective to the cholinergic nervous system and may be usefulas a potential therapeutic agent in diseases exhibiting cholinergic deficits.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Yabe, T., Toriizuka, K.and Yamada, H.: "Kami-untan-to(KUT)improves cholinergic deficits in aged rats" Phytomedicine. 2(1). 45-50 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yabe, T.and Yamada, H.: "Kami-untan-to enhance choline acetyltransferase and nerve growth factor mRNA levels in brain cultured cell" Phytomedicine. 2(3). 361-367 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 矢部 武士、山田 陽城: "「気血水」と中枢神経系に対する漢方方剤の作用-基礎研究から-" P&M Kampo. 1(3). 32-37 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yabe, T., Iizuka, S., Komatsu, Y.and Yamada, H.: "Enhancements of choline acetyltransferase activity and nerve growth factor Secvetion by Polygalae Radix-extract containing active ingredients on Kami-untan-to" Phytomedicine. 4(3). 199-205 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yabe, T.and Yamada, H.: "Induction mechanism of nerve growth factor synthesis by Kami-untan-to;Role of cyclic AMP and c-fos mRNA accumlation" Phytomedicine. 4(3). 191-198 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Yabe, K.Torizuka and H.Yamada: "Kami-untan-to (KUT) improves cholinergic deficits in aged rats." Phytomedicine. 2(3). 45-50 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Yabe, and H.Yamada: "Effects of Kampo medicines on central nevous systems" P&M Kampo. Vol.1, No.3. 32-37

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Yabe and H.Yamada: "Kami-untan-to echance choline acetyltransferase and nerve growth factor mRNA levels in brain cultured cells." Phytomedicine. 3(4). 361-367 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Yabe, S.Iizuka, Y.Komatsu, and H.Yamada: "Enhancements of choline acetyltransferase activity and nerve growth factor secretion by polygalae Radix-extract containing active ingredients on Kami-untan-to" Phytomedicine. 4(3). 199-205 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Yabe and H.Yamada: "Induction mechanism of nerve growth factor synthesis by Kami-untan-to ; Role of cycli AMP and c-fos mRNA accumulation." Phytomedicine. 4(3). 191-198 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Yabe, S.Iizuka, Y.Komatsu and H.Yamada: "Enhancements of choline acetyltransferase activity and nerpe growth factor secretion by Polygalae Radix-extnect contsining active ingredients on Kami- nutan-tc." Phytomedicine. 4(3). 199-205 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] T.Yabe and H.Yamada: "Induction mechanism of nerve growth factor synthesis by kami-untau-to)Role of cyclic AMP and c-fos mRNA accumulation" Phytomedicine. 4(3). 191-198 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] T.Yabe,K.Torizuka and H.Yamada: "Kami-untan-to (KUT) improves chdinergic deficits in aged rats" Phytomedicine. 2(1). 45-50 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Yabe and H.Yamada: "Kami-untan-to enhance choline acetyltransferase and nerve growth factor mRNA levels in brain cultured cells" Phytomedicine. 2(3). 361-367 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 矢部武士、山田陽城: "「気・血・水」と中枢神経系に対する漢方方剤の作用-基礎研究から-" P&M Kampo. 1(3). 32-37 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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