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Effects of ginseng root on nervous, endocrine and immune systems, and its application to an anti-stress drug

Research Project

Project/Area Number 08672566
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 医薬分子機能学
Research InstitutionIwate Medical University

Principal Investigator

TACHIKAWA Eiichi  Iwate Medical University, School of Medicine, Department of Pharmacology, Associate Professor, 医学部, 助教授 (50146031)

Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
KeywordsGinseng root / Ginseng saponin / Ginsenoside / Adrenal medulla / Adrenal cortex / Catecholamine / Cortisol / Stress / ムスカリン / 薬用人参 / 人参サポニン
Research Abstract

The aim of this study is to scientifically prove the pharmacological effect of ginseng root on nervous, endocrine and immune systems.
1.In the representative each group of ginseng saponins (the panaxadiol, the panaxatriol and the oleanolic saponins), the panaxatriol saponin ginsenoside-Rg_2 was a potent, selective bolocker of nicotinic acetylcholine receptors. On the other hand, the panaxadiol saponin ginsenoside-Rg_3 seemed to be antagonists for various receptors, while the oleanolic saponin ginsenoside-Ro did not affect them.
2.The inhibitory properties of ginsenoside-Rg_3 that strongly inhibited acetylcholine-induced catecholamine secretion from bovine adrenal chromaffin cells as a model of nervous systems exceptionally in the panaxadiol saponins was similar to those of ginsenoside-Rg_2, indicating that ginsenoside-Rg_3 as well as -Rg_2 inhibited the secretion due to the blockade of NA^+ influx through nicotinic acetylcholine receptor-operated cation channels.
3.There was the relationship between the inhibitory effects and the structures of ginseng saponins and the effect is a unique property for ginsenosides.
4.The saponin fraction suppressed the cortisol synthesis in adrenal fasciculata cells as a model of endocrine systems.
Furthermore, we are investigating the effects of ginseng root on polysaccharide-induced cytokine production in lymphocytes and the anti-stress action of ginseng root and ginsenosides in vivo.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 伊藤 浩司、立川 英一: "牛副腎皮質細胞のコルチゾール産生に対するインターフエロンの効果" 岩手医学雑誌. 49. 229-238 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 立川 英一、工藤 賢三 ら: "薬用人蔘サポニンの受容体-応答に対する効果" 日本薬理学雑誌. 110. 126p-131p (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tachikawa, E., Kondo, Y., et al.: "Effects of interferon-α reduces catecholamine secretion from bovine adrenal chromaffin cells stimulated by acetylcholine." Naunyn-Scmiedeberg's Arch.Pharmacol.356. 669-705 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kudo, K., Tachikawa, E., et al.: "Properties of ginseng saponin inhibition of catecholamine secretion in bovine adrenal chromaffin cells." Eur.J.Pharmacol.139. 341-144 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Itoh, K.and Tachikawa, E.: "Effects of interferons on cortisol synthesis in bovine cortical cells." J.Iwate med.Ass.49. 229-238 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tachikawa, E., Kudo, K., Kashimoto, T.and Takahashi, E.: "Effects of ginseng saponins on receptor stimulation-responses." Folia Pharmacol.Jpn.110. 126-131 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tachikawa, E., Kondo, Y., Kashimoto, T., Yanagihara, N., Toyohira, Y.and Izumi, F.: "Effects of interferon-alpha reduces catecholamine secretion from bovine adrenal chromaffin cells stimulated acetylcholine." Naunyn-Scmiedeberg's Arch.Pharmacol.356. 699-705 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kudo, K., Tachikawa, E., Kashimoto, T.and Takahashi, E.: "Properties of ginseng saponin inhibition of catecholamine secretion in bovine adrenal chromaffin cells." Eur.J.Pharmacol. 341. 139-144 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] E.Tachikawa, et al.: "Interferon-α reduces catecholamine secretion from bovine adrenal chromaffin cells stimulated by acetylcholine" Naunyn-Schmiedeberg′s Arch Pharmacol. 356. 699-705 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] K.Kudo, et al.: "Properties of ginseng saponin inhibition of catecholamine secretion in bovine adrenal chromaffin cells" Eur.J.Pharmacol.(in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] K.Kodo,et al.: "Comparison between ginsenoside-Rg_2 and -Rg_3 effects on catecholamine secretion from adrenal chromaffin cells" The Japanese Journal of Pharmacology. 73. 79P (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 立川英一ら: "紅参サポニンのアセチルコリン受容体拮抗作用" The Ginseng Review. 22. 103-106 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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