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中枢神経細胞の運動性変性予防と回復促進に関する運動処方作りのための基礎的研究

Research Project

Project/Area Number 08680109
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 体育学
Research InstitutionNagoya Institute of Technology

Principal Investigator

藤墳 規明  名古屋工業大学, 工学部, 教授 (60101268)

Co-Investigator(Kenkyū-buntansha) 藤墳 規明  名古屋工業大学, 工学部, 教授 (60101268)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordsラット海馬体 / 酸素分圧 / 神経細胞変性 / 酸素電極 / 持久的水泳 / 雌ラット / 頚動脈閉塞 / 海馬体アンモン角CAl / 細胞変性 / アルギニン染色 / 持久的水泳運動 / 細胞外グルコース濃度
Research Abstract

我々は、先の研究において、強度の強い運動を負荷すると、ラット海馬体の神経細胞に変性が起きることを報告した。本研究は、上述のような運動の中枢神経細胞に対するマイナスの効果を避けるための手立てを策定する目的で以下の基礎的研究を行った。実際には、海馬体の神経細胞が低酸素に極めて脆弱であることから、海馬体での酸素分圧に着目し、(1)酸素電極と測定補助具の意匠、および(2)水泳運動中のラット海馬体での局所酸素分圧の測定を行った。酸素電極は、+極に白金、-極にプラチナ線を用い、ポラログラフを描く方法を用いた。in vitro実験において、酸素分圧の測定誤差は変動係数にして平均4.6%であった。この酸素電極と補助具を用いて、水泳中のラット海馬体に平均4.6%であった。この酸素電極と補助具を用いて、水泳中のラット海馬体における局所酸素分圧を測定した。安静温水浴群には2時間の温水浴(33℃)、無負荷群には重りなしの2時間水泳、5g負荷群には5gの重りを付けた2時間水泳、さらに10g負荷群には10gの重りを付けた2時間水泳を課した。その結果、5g負荷群では、運動開始と共に酸素分圧の上昇が見られ、運動後には安静値に戻った。しかし、10g負荷群では、上述と同様に運動初期に酸素分圧の上昇が見られたが、運動後半から継続的に低下し、運動後の回復期には、安静値を有意に下回る値(70%)で推移した。このことは、中枢神経系のトレーニングには、軽度の持久的運動が効果的であることを示唆している。

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Nakai、N.、et al.: "Exercise training prevents muturation-induced decrease in insurin sensitivity"Journal of Applied Physiology. 80(6). 1963-1967 (1996)

    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoshimura、A.、et al.: "Glycogen depression of the intrafusal fibers in a mouse muscle spindle during prolonged swimmimg"American Journal of Physiology. 271. R398-R408 (1996)

    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakai、N.、et al.: "Activity of liver pyruvate dehydrogenase complex and 3-hyfroxyaclyl-CoA dehydrogenase in sand rat (psammomys obesus)"Life Science. 60. 51-56 (1996)

    • Related Report
      1998 Final Research Report Summary
  • [Publications] Taniguchi、K.、et al.: "The valine catabolic pathway in human liver : Effects of cirrhosis on enzyme activity"Hepatology. 24. 1395-1398 (1996)

    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakai、N.、et al.: "Effects of aging on the activities of pyruvate dehydrogenase complex and its kinase in rat heart"Life Science. 60. 2309-2314 (1997)

    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fujitsuka、N.、: "Intramembrane strucuture of the sensory axon terminals in bullfrog muscle spindles"Anatomical Record. 252. 340-354 (1998)

    • Related Report
      1998 Final Research Report Summary
  • [Publications] 伊藤文雄編: "クローズアップ生理学"名古屋大学出版会. 300 (1996)

    • Related Report
      1998 Final Research Report Summary
  • [Publications] 宮村実晴編: "最新運動生理学"真興交易医書出版. 404 (1996)

    • Related Report
      1998 Final Research Report Summary
  • [Publications] Murakami,T.: "Induction of nuclear respiratory factor-1 expression by an acute bout of exercise in rat muscle" Biochemical et Biophysica Acta. 1381. 113-122 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fujitsuka,N.: "Intramembrane structure of the sensory axon terminals in bullfrog muscle spindle" Anatomical Record. 252. 340-354 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tsukamura,M.: "Dietary maltitol decreases the increase of 1,2-dimethylhydrazine-induced cecum and proximal colon tumors in rats." Journal of Nutrition. 128. 536-540 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakai,N.: "Insulin activation of pyruvate dehydrogenase complex is enhanced by exercise training" Metabolism. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] 今泉和彦・石原昭彦: "最新運動生理科学実験法" 大修館書店, 280 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Taniguchi,K.: "The valine catabolic pathway in human liver : Effect of cirrhosis on enzyme activities" Hepatology. 24. 1395-1398 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakai,N: "Effects of aging on the activities of pyruvate dehydrogenase complex and its kinase in rat heart" Life Science. 60. 2309-2314 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakai,N: "Activities of liver pyruvate dehydrogenase complex and 3-hydroxyacyl-CoA dehydrogenase in sand rat (PSAMMOMYS OBESUS)" Life Science. 60. 51-55 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Murakami,T.: "Enlargement of glycogen store in rat liver and muscle by fructose-diet intake and exercise training" Journal of Applied Physiology. 82. 772-775 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kobayashi,R.: "Gender difference in regulateion of branched-chin amino acid catabolism" Biochemical Journal. 327. 449-453 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Fujitsuka,N.: "Expression of immediate early gene followed by a bout of endurance treadmill run in the hippocampal neurons of rats" Abstracts of XXXIII International Congress of Physiological Sciences. 9061-27 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 伊藤文雄編: "クローズアップ臨床栄養学" 名古屋大学出版会, 350 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 今泉和彦・石原昭彦編: "運動生理学実験法" 大修館書店, 300 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakai,N.: "Exercise training prevents muturation-induced decrease in insulin sensitivity." Journal of Applied Physiology. 80(6). 1963-1967 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yoshimura,A.: "Glycegen depletion of the intrafusal fibers in a mouse muscle spindle during prolonged swimming." American Journal of Physiology. 271. R398-R408 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nakai,N.: "Activities of liver pyruvate dehydrogenase complex and 3-hydroxyaclyl-CoA dehydrogenase in sand rat (Psammomys obesus)." Life Science. 60. 51-55 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Taniguchi,K.: "The valine catabolic pathway in human liver : Effect of cirrhosis on enzyme activities." Hepatology. 24. 1395-1398 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nakai,N.: "Effects of aging on the activities of pyruvate dehydrogenase complex and its kinase in rat heart." Life Science. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Murakami,T.: "Enlargement of glycogen store in rta liver and muscle by fructose diet and exercise training" Journal of Applied Physiology. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] 伊藤文雄編: "名古屋大学出版会" クローズアップ生理学, 243 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 宮村実晴編: "新興貿易医書出版" 最新生理学, 404 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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