| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Research Abstract |
Free radicals such as ROO can react at random by hydrogen abstraction and a variety of reactions to damage proteins, lipids and vitamins. Many diseases, such as atherosclerosis, inflammation and Perkinson's disease have been proven to be caused by oxygen-derived free radicals.
In this study, we succeeded the efficient synthesis of O^4, O^9-dimethylstealthin A and C,methylated derivatives of potent radical scavengers produced by Streptomyces viridochromogenes, using Suzuki coupling reaction as a key step. This work offers new, rather stable and useful compounds for studying free radical scavenging actions.
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