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Difference of relay modes in synaptic organization of the somatic and visceral thalamic nuclei.

Research Project

Project/Area Number 08680810
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NAKAMURA Yasuhisa  Tokyo Medical & Dental Univ.Faculty of Medicine, Professor, 医学部, 教授 (70025625)

Co-Investigator(Kenkyū-buntansha) IZUMI Masahide  Tokyo Medical & Dental Univ.Faculty of Medicine, Research Associate, 医学部, 助手 (70262186)
SATO Fumi  Tokyo Medical & Dental Univ.Faculty of Medicine, Research Associate, 医学部, 助手 (60205961)
OTAKE Kazuyoshi  Tokyo Medical & Dental Univ.Faculty of Medicine, Lecturer, 医学部, 講師 (10168966)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordsthalamus / VL / VA / PVT / MGN / thalamic reticular nucleus / axonal transport / EM 3-D reconstruction / 小脳 / 脚内核
Research Abstract

We observed light and electron microscopically somatic and visceral thalamic nuclei to know their characteristics of the synaptic organization. Wechose the ventral lateral (VL) and ventral anterior (VA) nuclei as the motor, the medial geniculate nucleus (MGN) as the sensory and the paraventricular thalamic nucleus (PVT) as the visceral nuclei.
In the VL,three-dimensional reconstruction from serial ultrathin sections revealed that cerebellar terminals (CLRs) predominantly made synaptic contacts on primary and secondary dendrites of thalamocortical projection neurons (TCNs), whereas, cortical terminals made synapses on distal dendrites. Presynaptic dendrites (PSDs) of intrinsic neurons and axon terminals of unidentified origins (Ps) made synapses on every order of dendrites and neuronal somata. The synaptic complex (synaptic triad), formed by the CLR,dendrites of the TCN and the PSD was also analyzed. Terminals from the thalamic reticular nucleus (TRN), which belong to P were located independently from the synaptic triad. In the VA,entopeduncular terminals (ELPs) mainly made synaptic contacts with somata and primary dendrites of TCNs. The synaptic triad among the ELP,TCN dendrites and PSD was also observed. Because the ELP is inhibitory in nature, the PSD may play a role of disinhibition against the TCN.TRN terminals in the VA often showed serial synapses in which they were posynaptic to ELPs or terminals with round vesicles.
We studied the corticocortical connections to know the morphological bases of auditory information processing. During this study we examined the relationship between auditory related cortical areas and the subnuclei of the MGN precisely.
About the PVT,we proved that neurons in the Barrington's nucleus which is known as the micturition center sent axons to both the spinal cord and the PVT by axon collaterals. We also observed that many PVT neurons gave off axons to both the limbic cortex and nucleus accumbens by collaterals.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Ruggiero, D.A., Mutui, E.P., Otgake, K. & Anwar, M.: "Central and primary visceral afferents to nucleus tractus colitarii may generate nitric oxide as a membrane-permaeant neuronal messenger." Journal of Comparative Neurology. 364. 51-67 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Otake, K. & Nakamura, Y.: "Single neurons in Barrigton´s nucleus projecting to both the paraventricular thalamic nucleus and the spinal cord by way of axon collaterals:a double labeling study in the rat." Neuroscience Letters. 209. 97-100 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sato, F., Nakamura, Y. & Shinoda, Y.: "Three-dimensional analysis of cerebellar terminals and their postsynaptic components in the ventral lateral nucleus of the cat thalamus." Journal of Comparative Neurology. 371. 537-551 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ruggiero, D.A., Mtui, E.P.Otake, K. & Anwar, M.: "Vestibular afferents to the dorsal vagal complex:substrate for vestibular-autonomic interactions in the rat." Brain Research. 743. 294-302 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sato, F., Nakamura, Y. & Shinoda, Y.: "Serial electron microscopic reconstruction ofaxon terminals on physiologically identified thalamocortical neurons in the cat ventral lateral nucleus." Journal of Comparative Neurology. 388. 613-631 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Otake, K. & Nakamura, Y.: "Single midline thalamic neurons projecting toboth the ventral striatum and the prefrontal cortex in the rat." Neuroscience. (in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Izumi, M. & Nakamura, Y.: "The organization of the ipsilateral corticocortical projections of the middle sylvian syrus(A II)in the cat cerebral cortex:an anterograde and retrograde tracing study." Brain Research Bull.(in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ruggiero, D.A., Mtui, E.P., Otake, K.& Anwar, M.: "Central and primary visceral afferents to nucleus tractus solitarii may generate nitric oxide as a membrane-permeant neuronal messenger." J.Comp.Neurol. 364. 51-67 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Otake, K.& Nakamura, Y.: "Single neurons in Barrigton's nucleus projecting to both the paraventricular thalamic nucleus and the spinal cord by way of axon collaterals : a double labeling study in the rat." Neurosci.Lett.209. 97-100 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sato, F,Nakamura, Y.& Shinoda, Y.: "Three-dimensional analysis of cerebellar terminals and their postsynaptic components in the ventral lateral nucleus of the cat thalamus." J.Comp.Neurol.371. 537-551 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ruggiero, D.A., Mtui, E.P., Otake, K.& Anwar, M.: "Vestibular afferents to the dorsal vagal complex : substrate for vestibular-autonomic interactions in the rat." Brain Res.743. 294-302 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sato, F., Nakamura, Y.& Shinoda, Y.: "Serial electron microscopic reconstruction of axon terminals on physiologically identified thalamocortical neurons in the cat ventral lateral nucleus." J.Comp.Neurol.388. 613-631 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Otake, K.& Nakamura, Y.: "Single midline thalamic neurons projecting to both the ventral striatum and the prefrontal cortex in the rat." Neuroscience. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Izumi, M.& Nakamura, Y.: "The organization of the ipsilateral corticocortical projections of the middle sylvian gyrul (A II) in the cat cerebral cortex : an anterograde and retrograde tracing study." Brain Res.Bull.(in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ruggiero,D.A., Mtui,E.P.Otake,K. & Anwar,M.: "Vestibular afferents to the dorsal vagal complex: substrate for vestibular-autonomic interactions in the rat." Rrain Research. 743. 294-302 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sato,F.,Nakamura,Y. & Shinoda,Y.: "Serial electror.microscopic reconstruction of axon terminals on physiologically identified thalamocortical neurous in the cat ventral lateral nucleus." Journal of Comparative Neurology. 388. 613-631 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Otake,K. & Nakamura,Y.: "Single midline thelamic neurons projecting to both the ventral striatum and the prefrontal cortex in the rat." Neuroscience. in press. (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Izumi,M. & Nakamura,Y.: "The organization of the ipsilateral corticocortical projections of the middle sylvian gyrus (A II)in the cat cerebral cortex : an anterograde and retrograde tracing study." Brain Research Bull.(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sato,F.,Nakamura,Y.& Shinoda,Y.: "Three-Dimensional Analysis of Cerebellar Terminals and Their Postsynapic Components in the Ventral Lateral Nucleus of the Cat Thalamus" Journal of Comparative Neurology. 371. 537-551 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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