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Differences of horizontal collateralizations in commissure and association neurons

Research Project

Project/Area Number 08680827
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionToho University

Principal Investigator

OJIMA Hisayuki  Toho Univ Sch Med Dept Anat, Assist Prof, 医学部, 講師 (00104539)

Co-Investigator(Kenkyū-buntansha) KAKUTA Sachiko  Toho Univ Sch Med Dept Anat, Assist Prof, 医学部, 講師 (80057752)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1998: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1997: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1996: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsIntracellular recording / Excitatory postsynaptic potential / Inhibitory postsynaptic potential / Pyramidal neuron / Auditory cortex / Best frequency / Binaurality / Sound intensity / Non-moroTonic / バイオサイチン / 軸索 / 抑制性シナプス電位
Research Abstract

Responses of layer 2/3 pyramidal neurons to sound stimuli were recorded intracellularly. Under a light Nembutal anaesthesia, pure tones, clicks, white noises, and noises with a defined band width were applied to cats' external meatus under monaural and/or binaural conditions. In many neurons, biocytin was injected after the recording to trace the courses of axons of the recorted neurons.
Excitatory postsynaptic potentials (EPSPs) were induced with best or nearbest frequencies. EPSPs, often associated with action potentials, were followed by hyperpolarizing deflection of the membrane potential (IPSP), which was more conspicous in layer 3 neurons than in layer 2 neurons. In some neurons, if sound intensity was increased, IPSP deflection was increased together with the decreased number of action potentials, revealing the non-monotonic response properties. In some deep layer 3 neurons, binaural stimulation with the best or near-best frequencies or with noise induced less spikes than monaural stimulation of either ear, revealing the EI response properties. Then stronger IPSPs were associated with the binaural stimulation than monaural stimulaiton, and seem to reduce the number of binaurally-induced spikes.
In order to compare axonal trajectories of the neurons with IPSP and without IPSP, some of the recorded and then biocytin-injected neurons have been reconstructed.
These results and some related data have been published in abstract forms and/or in full papers.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] OJIMA et al.: "Molecular Heterogeneity of Vicia villosa-recognized ・・・" Brain Research. 786. 274-280 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] He et al.: "Temporal Integration and Duration Tuning ・・・" J.Neuroscience. 17. 2615-2625 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小島久幸, 小田哲子: "大脳新皮質の水平軸索結合" 脳21. 1. 49-57 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小島久幸 他: "音刺激に対するネコ聴覚皮質錐体細胞の興奮性、抑制性 ・・・" 日本音響学会聴覚研究会資料. H-98-38. 1-8 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] OJIMA & He: "Cortical Convergence Originating from Domains ・・・" Acta Otoralyngologica. S532. 126-128 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小島久幸 他: "聴覚皮質の神経連絡" 日本音響学会誌. 53. 383-391 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ojima H,Murakami K,and Kishi K: "Dual termination modes of corticothalamic fibers originating from pyramids of layers 5 and 6 in cat visual cortical area 17." Neurosci Letters. 208. 57-60 (1966)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ojima H and He J-F: "Cortical convergence originating from domains representing different frequencies in the cat Al." Acta Otolaryngol. S532. 126-128 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ojima H: "Neural network of auditory cortex (Japanese)" The Journal of the Acoustical Society of Japan. 53. 383-391 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] He J-F,Hashikawa T,Ojima H and Kinouchi Y: "Temporal integration and duration tuning in the dorsal zone of cat auditory cortex." J Neurosci. 17. 2615-2625 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ojima H,Sakai M,and Ohyama J: "Molecular heterogeneity of Vicia villosa-recongized perineuronal nets surrounding pyramidal and nonpyramidal neurons in the guinea pig cerebral cortex." Brain Res. 786. 274-280 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ojima H,and Oda S: "Horizontal collaterals in neocortex (Japanese)" BRAIN 21. 1. 49-57 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ojima H,Murakami K,and Kishi K: "Excitatory and inhibitory membrane responses of pyramidal neurons to sound stimuli in cat primary auditory cortex (Japanese)." Reports for auditory research meeting of the Acoustical Society of Japan.H-98-38. 1-8 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] OJIMA et al.: "Molecular Heterogeneity of Vicia, Villosa-recognized." Brain Research. 786. 274-280 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] He et al.: "Temporal Integration and Duration Tuning." J.Neuroscience. 17. 2615-2625 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小島久幸 他: "音刺激に対するネコ聴覚皮質錐体細胞の興奮性、抑制" 日本音響学会聴覚研究会資料. H-98-38. 1-8 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小島久幸 他: "大脳新皮質の水平軸策結合" 脳21. 1. 49-57 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ohyama & Ojima: "Labeling of Pyramidal and Nonpyramidal Neurons with ・・・・" The Journal Comparative Neurology. 389. 453-468 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ojima & He: "Cortical convergence originating from domains representing ・・・・" Acta Otolaryngologica. S532. 126-128 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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