• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Functional analysis of the novel brain-specific receptor tyrosine kinase "Sky"

Research Project

Project/Area Number 08680840
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionOsaka University

Principal Investigator

FUNAKOSHI Hiroshi  Osaka University, Assistant Professor, 医学部, 助手 (40273685)

Co-Investigator(Kenkyū-buntansha) MIYAMOTO Kazumasa  Osaka University, Assistant Professor, 医学部, 助手 (60273679)
NAKAMURA Toshikazu  Osaka University, Professor, 医学部, 教授 (00049397)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1997: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1996: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsMolecular cloning / Sky / Axl / c-Mer / Gas6 / Protein S / tyrosine kinase / neurotrophic / tyrosine kinase receptor / ProteinS / survival / neuron
Research Abstract

Sky (also known as Tyro3 and Rse) (Ohashi, et al.1994) is a member of Axl/UFO receptor tyrosine kinase family, which has two immunoglobulin (Ig)-like repeats and two fibronectin type III (FN III) -like repeats in the extracellular domain. Recently, Gas6 has been identified as ligand for all members of Axl receptor tyrosine kinase family ; Axl, Sky and c-Mer with different affinity (in this order). However physiological function of Sky and Gas6 in the nervous system are poorly understood, despite its importance in the nervous system suggested by the structural feature and predominant expression of Sky in the brain. Here we show by RNAse protection assay (RPA) and/or by in situ hybridization analysis that sky and gas6 mRNAs were expressed in adult hippocampus from CA1 region to CA3 region and dentate gyrus.
Furthermore this expression was regulated in a similar manner during development ; levels were low during embryonic stages, gradually increased during development and reaching its highest levels in the adult. Sky-but not Axl-immunoreactivity was observed in the pyramidal layr of adult hippocampus, suggesting the roles of Sky and Gas6 hippocampus during development and in the adult. Recombinant rat Gas6 attenuated hippocampal neuronal cell death caused by serum starvation in vitro, indicating that Gas6 is a novel neurotrophic factor for hippocampal neurons in vitro. Finally, gas6 showed regulated expression in the hippocampus after kainic acid stimulation and in the sciativ nerve after nerve transection. Taken together, these findings indicate the physiological importance of Gas6 and Sky receptor tyrosine kinase in both central and peripheral nervous systems.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (111 results)

All Other

All Publications (111 results)

  • [Publications] H.Funakoshi, et al.: "Targdted expreesion of a mulifunctional chimeric neurotrophin to the lesioned nerve accerelate both sensory and motor axons." Proc.Natl.Acad.Sci USA. (in press.). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S.Mizuno, et al.: "Hepatocyte growth factor prevents renal fibrosis and dysfunction in mouse model of chronio renal disease." J.Clin.Invest.(in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Ohmichi, et al.: "Hepatocyte growth factor(HGF)acts as a mesenchymal-derived morphogenic factor during fetal lung development." Development. (in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Miyazawa, et al.: "Protection of hippocampal neurons from is chemia-induced delayed neuronal death by hepatocyte growth factor:A novel neurotrophic factor." J.Celebral Blood Flow metabolism. (in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Lyon, et al.: "Hepatocyte growth factor/scatter factor binds with high affinity to dermatan sulphate." J.Biol.Chem.273. 271-278 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Trupp, et al.: "Complementary and overlapping expression of glial cell line-derived neurotrophic factor(GDNF),c-ret prot-oncogene,and GDNF receptor alpha indicates multiple mechanisms of trophic actions in the adult rat CNS." J.Neurosci. 10. 3554-3567 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Takai, et al.: "Hepatocyte growth factor is constitutively produced by human bone marrow stromal cells and promotes erythropoiesis." Blood. 89. 1560-1565 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] I.S.Weimar, et al.: "Hepatocyte growth factor/scatter factor(HGF/SF)promotes ddhesion of lymphoma cdls to extra-cellular matrix molecules via α4β,and α5β,integrins." Blood. 89. 990-1000 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Nakamura, et al.: "Induction of hepatocyte growth factor in fibroblasts by tumor-denved factors affects invasive growth of tumor cells:In vitro analysis of tumor-stromal interaction." Cancer Res.57. 3305-3313 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] P.Naveilhan, et al.: "1,25-Dihydroxyvitamin D3 regulates the expression of the low-affinity neurotrophin receptor" Mol.Brain Res.41. 259-268 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Hamanoue, et al.: "Neurotrophic effect of hepatocyte growth factor on CNS neurons in vivo." J.Neurosci.Res.43. 554-564 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.J.Tabata, et al.: "Hepatocyte growth factor is involved in the morphogenesis of tooth gern in murine molars." Development. 122. 1243-1251 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Sugimoto, et al.: "Molecular cloning and characterization of a newly identified member of the cadherin family,PB-cadherin." J.Biol.Chem.271. 11548-11556 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Takahashi, et al.: "Hepatocyte growth factor as a key to modulate anti-ulcer action of prostaglandins in stomach." J.Clin.Invest.98. 2604-2611 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] G.Shiota, et al.: "Coexpression of hepatocyte growth factor and its receptor(c-met oncogene)in HGL4 glioblastoma cells." Oncology. 53. 511-516 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 船越 洋: "シナプス-形成と再形成:Sprouting." Clin.Neurosci. 15. 65-68 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 船越 洋、中村 敏一: "運動ニューロン変性と神経栄養因子" 神経研究の進歩. 885-898 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 船越 洋: "運動神経系におけるニューロトロフィン-4の機能" 実験医学. 14. 71-75 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Funakoshi, et al.: "Targeted expression of a multifunctional chimeric neurotrophin to the lesioned nerve accerelate both sensory and motor axons." Proc.Natl.Acad.Sci USA.(in press.).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S.Mizuno, et al.: "Hepatocyte growth factor prevents renal fibrosis and dysfunction in mouse model of chronio renal disease." I.Clin.Invest.(in press.).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Ohmichi, et al.: "Hepatocyte growth factor (HGF) acts as a mesenchymal-derived morphogenic factor during fetal lung develpment." Development. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Miyazawa, et al.: "Protection of hippocampal neurons from ischemia-induced delayd neuronal death by hepatocyte growth factor : A novel neurotrophic factor." J.Celebral Blood Flow Metabolism.(in press.).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Lyon, et al.: "Hepatocyte growth factor/scatter factor binds with high affinity to dermatan sulphate." J.Biol.Chem.273. 271-278 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Trupp, et al.: "Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor alpha indicates multiple mechanisms of trophic actions" in the adult rat CNS.J.Neurosci.10. 3554-3567 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Takai, et al.: "Hepatocyte growth factor is constitutively produced by human bone marrow stromal cells and promotes erythropoiesis." Blood. 89. 1560-1565 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] I.S.Weimar, et al.: "Hepatocyte growth factor/scatter factor (HGF/SF) promotes adhesion of lymphoma cells to extra-cellular matrix molecules via alpha4beta, and alpha5beta" integrins.Blood. 89. 990-1000 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Nakamura, et al.: "Induction of hepatocyte growth factor in fibtoblasts by tumor-derived factors affects invasive growth of tumor cells : In vitro analysis of tumor-stromal interaction." Cancer Res.57. 3305-3313 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] P.Naveilhan, I.et al.: "1,25-Dihydroxyvitamin D3 regulates the expression of the low-affinity neurotrophin receptor." Mol.Brain Res.41. 259-268 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Hamanoue, et al.: "Neurotrophic effect of hepatocyte growth factor on CNS neurons in vivo.J.Neurosci." Res.43. 554-564 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.J.Tabata, et al.: "Hepatocyte growth factor is involved in the morphogenesis of tooth gern in murine molars." Development. 122. 1243-1251 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Sugimoto, et al.: "Molecular cloning and characterization of a newly identified member of the cadherin family, PB-cadherin." J.Biol.Chem.271. 11548-11556 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Takahashi, et al.: "Hepatocyte growth factor as a key to modulate anti-ulcer action of prostaglandins in stomach." J.Clin.Invest.98. 2604-2611 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] G.Shiota, et al.: "Coexpression of hepatocyte growth factor and its receptor (c-met oncogene) in HGL4 glioblastoma cells." Oncology. 53. 511-516 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Matsumoto, et al.: "HGF : its organotrophic role and therapeutic potential." "Plasminogen-Related Growth Factors" Ciba Foundation Symposium. No.212. 198-214 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Matsumoto, et al.: "Hepatocyte growth factor (HGF) as a tissue organizer for organogenesis and regeneration" Biochem.Biophys.Res.Commun.239. 639-644 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Matsumoto and T.Nakamura: "Pathophysiological aspects and therapeutic potential of hepatocyte growth factor in liver disease." "Internal Medicine and Endocrinology : Pathophysiological and clinical interactions" (eds A.Fabbrini and V.Santiemma.). 95-106 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Matsumoto et al.: "Emerging multipotent aspects of hepatocyte growth factor." J.Biochem.119. 591-600 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Funakoshi, et al.: "Targeted expression of a mulifunctional chimeric neurotrophin to the lesioned nerve accerelate both sensory and motor axons." Proc.Natl.Acad.Sci USA. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] S.Mizuno, et al.: "Hepatocyte growht factor prevents renal fibrosis and dysfunction in mouse model of chronio renal disease." J.Clin.Invest.(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Ohmichi, et al.: "Hepatocyte growth factor (HGF) acts as a mesenchymal-deried morphogenic factor during fetal lung develpment." Development. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] T.Miyazawa, et al.: "Protection of hippocampal neurons from ischemia-induced delayed neuronal death by hepatocyte growth factor : A novel neurotrophic factor." J.Celebral Blood Flow Metabolism. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Lyon, et al.: "Hepatocyte growth factor/scatter factor binds with high affinity to dermatan sulphate." J.Biol.Chem.273. 271-278 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Trupp, et al.: "Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF),c-ret proto-oncogene,and GDNF receptor alpha indicates multiple mechanisms of trophic actions in the adult rat CNS." J.Neurosci. 10. 3554-3567 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] K.Takai, et al.: "Hepatocyte growth factor is constitutively produced by human bone marow stromal cells and promotes erythropoiesis." Blood. 89. 1560-1565 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] I.S.Weimar, et al.: "Hepatocyte growth factor/scatter factor (HGF/SF) promotes adhesion of lymphoma cells to extra-cellular matrix molecules via α4β,and α5β,integrins." Blood. 89. 990-1000 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] T.Nakamura, et al.: "Induction of hepatocyte growth factor in fibroblasts by tumor-derived factors affects invasive growth of tumor cells : In vitro analysis of tumor-stromal interaction." Cancer Res.57. 3305-3313 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] P.Naveilhan, et al.: "1,25-Dihydroxyvitamin D3 regulates the expression of the low-affinity neurotrophin receptor" Mol.Brain Res.41. 259-268 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Hamanoue, et al.: "Neurotrophic effect of hepatocyte growth factor on CNS neurons in vivo." J.Neurosci.Res.43. 554-564 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.J.Tabata, et al.: "Hepatocyte growth factor is involved in the morphogenesis of tooth gern in murine molars." Development. 122. 1243-1251 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] K.Sugimoto, et al.: "Molecular cloning and characterization of a newly identified member of the cadherin family,PB-cadherin." J.Biol.Chem.271. 11548-11556 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Takahashi, et al.: "Hapatocyte growth factor as a key to modulate anti-ulcer action of prostaglandins in stomach." J.Clin.Invest.98. 2604-2611 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] G.Shiota, et al.: "Coexpression of hepatocyte grow factor and its receptor(c-met oncogene) in HGL4 glioblastoma cells." Oncology. 53. 511-516 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 船越洋: "シナプス-形成と再形成:Sprouting." Clin.Neurosci. 15. 65-68 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 船越洋、中村敏一: "運動ニューロン変性と神経栄養因子" 神経研究の進歩. 885-898 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 船越洋: "運動神経系におけるニューロトロフィン-4の機能" 実験医学. 14. 71-75 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Funakoshi,T.Yonemasu and T.Nakamura: "Molecular cloning and regulation of rat axl tyrosine kinase receptor compared with its putatice ligands gas6 and proteinS in the nervous system" Soc.Neurosci.22. S305.15 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Trupp,N.Belluardo,H.Funakoshi,and C.F.Ibanez: "Complementary and overlappinug expression of GDNF,Ret and GDNF receptor-alpha indicates multiple mechanisms of trophic actions・・・" J.Neurosci.(in press.). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 船越洋: "運動神経系におけるニューロトロフィン-4の機能" 実験医学. 14. 71-74 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 船越洋: "Sprouting" Clinical Neuroscience. Vol.15(3). 289-292 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Yamazaki et al.: "Biphasic changes in serum hepatocyte growth factor after transcatheter arterial chemoembolization theraphy for hepatocellular carcinoma." Cytokine. 8. 178-182 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Imai et al.: "Expression of hepatocyte growth factor and c-met mRNAs during rat chemically induced hepatocarcinogenesis in the Solt-Farber model." Carcinogenesis. 17. 19-24 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] I.Fabregat et al.: "Epidermal growth factor,but not hepatocyte growth factor,suppresses the apoptosis induced by transforming growth factor-beta in fetal hepatocytes in primary culture." FEBS Lett.384. 14-18 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] P.Gines et al.: "Inhibitory actions of cyclic adenosine monophosphate and pertussis toxin define two distinct epidermal growth factor-regulated pathways leading to activation of mitogen-activated protein kinase in rat hepatocytes." Hepatology. 23. 1167-1173 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] K.Sugimoto et al.: "Molecular cloning and characterization of a newly identified member of the cadherin family,PB-cadherin." J.Biol.Chem.271. 11548-11556 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Takada et al.: "HGF prevent tacrolimus (FK506) -induced nephrotoxicity in SHR rats." Transplant.Proc.28. 1089-1090 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Adachi et al.: "Mitogen-activated protein kinase activation in hepatocyte growth factor-stimulated rat hepatocytes : Involvement of protein tyrosine kinase and protein kinase C." Hepatology. 23. 1244-1253 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.J.Gomez-Lechon et al.: "Cell cycle progression proteins (cyclins),oncogene expression and signal transduction during the proliferative response of human hepatocytes to hepatocyte growth factor." Hepatology. 23. 1012-1019 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Adachi et al.: "Phospholipase D activation in hepatocyle growth factor-stimulated rat hepatocytes mediates the expression of c-jun and c-fos : Involvement of protein tyrosine kinase,protein kinase C,and Ca^<2+>." Hepatology. 24. 1274-1281 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] K.Liu et al.: "Change in hepatic handling of hepatocyte growth factor during liver regeneration in rats." Am.J.Physiol.269(in press). (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] N.Torok et al.: "Upregulation of molecular motor encoding genes during HGF-and EGF-induced cell motility." J.Biol.Chem.(in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Hiscox et al.: "Expression of HGF/SF and its receptor cMET in human colon cancers." Cancer Investigations. (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] G.Shiota et al.: "Coexpression of hepatocyte growth factor and its receptor (c-met oncogene) in HGL 4 glioblastoma cells." Lab.Invest. (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] K.Takai et al.: "Hepatocyte growth factor is constitutively produced by humman bone marrow stromal cells and promotes erythropoiesis." Blood. (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] K.Matsumoto et al.: "Acquisition of invasive phenotype in gallblader cancer cells via looped interaction of stromal fibroblasts and canoer cells mediated by HGF." Jap.J.Cancer Res.87. 702-710 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Nakamura et al.: "Cloning and expression of xenopus HGF-like protein (HLP) and Ron/HLP receptor implicate their involvement in early neural development." Biochem.Biophys.Res.Commun.224. 564-573 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.G.Chang et al.: "Serum Repatocyte growth factor concentration in patients with various degrees of chronic renal failure." Nephrology. 2. 175-179 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Ueno et al.: "Exogenous hepatocyte growth factor markedly stimulates liver regeneration following portal branch ligation in dogs." Cancer Chemoter.and Pharmacol.38. 233-237 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Nakamura et al.: "A vaschlar modulator,hepatocyte growth factor (HGF),is associated with systolic blood pressure." Hypertension. 28. 409-413 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] E.Ichimura et al.: "Over expression of c-met/HGF receptor in human non small cell lung cancinoma in vitro and in vivo its prognostic significance." Jap.J.Cancer Res.87. 1063-1069 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] W.G.Jiang et al.: "Hepatocyte growth factor induces tyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin and enhances cell matrix interaction." Oncology Reports. 3. 819-823 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Aoki et al.: "Molecular cloning of Xenopus c-met/hepatocyte growth factor receptor and its regional expression during early development." J.Biochem.120. 961-968 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Iwazawa et al.: "Primary human fibroblasts induce diverse tumor invasiveness -Involvement of HGF as an important paracrine factor." Jap.J.Cancer Res.87. 1134-1142 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Kasai et al.: "Hepatocyte growth factor is a paracrine regulator of rat prostate epithelial growth." Biochem.Biophys.Res.Commun.228. 646-652 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Takahashi et al.: "Hepatocyte growth factor as a key to modulate anti-ulcer action of prostaglandins in stomach." J.Clin.Invest.98. 2604-2611 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] G.Shiota et al.: "Inhibitory effect of hepatocyte growth factor on metastosis of hepatocellular carcinoma in transgenic mice." Res.Commun.Mole.Pahol.Pharmacol.91. 33-39 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] K.Matsumoto et al.: "Heparin functions as a hepatotrophic factor by inducing production of hepatocyte growth factor." Biochem.Biophys.Res.Commun.227. 455-461 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Nakamura et al.: "Ikpatocyte growth factor (HGF) is a novelmember of endothelium-specific growth factors : additive stimulatory effect of HGF with basic fibroblast growth factor,but not vascular endothelial growth factor." J.Hypertens.14. 1067-1072 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Mizuguchi et al.: "Recovery of mRNA expression of tryptophan 2,3-dioxygenase and serine dehydratase in long-term cultures of primary rat hepatocytes." J.Biochem.120. 511-517 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] A.Uchiyama et al.: "Interleukin 4 inhibits hepatocyte growth factor-induced invasion and migration of colon carcinoma." J.Cell.Biochem.62. 443-453 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Dalmau et al.: "Nitric oxide inhibits DNA synthesis and induces activation of poly (ADP-ribose) polymerase in cultured rat hepatocytes." Exp.Cell Res.228. 14-18 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Z.G.Han et al.: "Regulaition of motility,invasiveness and growth of lung cancer cells by hepatocyte growth factor/scatter factor." Surg.Res.Commun.18. 217-229 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Hayashi et al.: "Autocrine-paraqrine effects of over-expression of hepatocyte growth factor gene on growth of endothelial cells." Biochem.Biophys.Res.Commun.220. 539-545 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Amaike et al.: "Human recombinant HGF prevents lethal side effects of cyclosporin A in mice." Cytokine. 8. 387-394 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] R.J.Mason et al.: "Hepatocyte growth factor is a mitogen for alveolar type II cells in rat lavage fluid." Am.J.Physiol.271. L46-L53 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] N.Nakayama et al.: "Hepatocyte growth factor and c-mer expression in Long-Evans Cinnamon rats with spontaneous hepatitis and hepatoma." Hepatology. 24. 596-602 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Ohmichi et al.: "In vivo mitogenic action of hepatocyte growth factor on branchial epithelial cells : Pulmotrophic role of HGF in lung regeneration." Am.J.Physiol.270. L1031-L1039 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.I.Guillen et al.: "The hepatocyte growth factor regulates the synthesis of acute-phase proteins in human hepatocytes. Divergent effects on IL-6-stimulated genes." Hepatology. 23. 1345-1352 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Hayashi et al.: "Autocrine-paraqrine effects of over-expression of hepatocyte growth factor gene on growth of endothelial cells." Biochem.Biophys.Res.Commun.220. 539-545 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Amaike et al.: "Human recombinant HGF prevents lethal side effects of cyclosporin A in mice." Cytokine. 8. 387-394 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] R.J.Mason et al.: "Hepatocyte growth factor is a mitogen for alveolar tyoe II cells in rat lavage fluid." Am.J.Physiol.271. L46-L53 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] N.Nakayama et al.: "Hepatocyte growth factor and c-met expression in Long-Evans Cinnamon rats with spontaneous hepatitis and hepatoma." Hepatology. 24. 596-602 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Ohmichi et al.: "In vivo mitogenic action of hepatocyte growth factor on branchial epithelial cells : Pulmotrophic role of HGF in lung regeneration." Am.J.Physiol.270. L1031-L1039 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.I.Guillen et al.: "The hepatocyte growth factor regulates the synthesis of acute-phase proteins in human hepatocytes. Divergent effects on IL-6-stimulated genes." Hepatology. 23. 1345-1352 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Kubo et al.: "Hepatocyte proliferation induced in rats by lead nitrate is suppressed by several tumor necrosis factor-α inhibitors." Hepatology. 23. 104-114 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Takada et al.: "Serum HGF levels in acute renal rejection after living related renal transplantation." Transplant.Intern.9. 151-154 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Joaquin et al.: "Hepatocyte growth factor and transforming growth factor beta regulates 6-phosph of ructo-2-kinase/fructose-2,6-bisphos-phatase gene expression in rat hepatocyte primary cultures." Biochem.J.314. 235-240 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Takahashi et al.: "Constitutive expression of hepatocyte growth factor may maintain the sheet construction of gastric epithelial cells through facilitating actin-myosin contractile system." Biochem.Biophys.Res.Commun.219. 40-46 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.J.Tabata et al.: "Hepatocyte growth factor is involved in the morphogenesis of tooth gern in murine molars." Development. 122. 1243-1251 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Kobayashi et al.: "Induction of hepatocyte growth by intraportal infusion of hepatocyte growth factor into beagle dogs." Biochem.Biophys.Res.Commun.220. 7-12 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 中村敏一: "バイオサイエンス用語ライブラリー" 羊土社, 232 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 松本邦夫 他: "骨形成・吸収シグナリングと骨疾患" 羊土社, 90-96 (1996)

    • Related Report
      1996 Annual Research Report

URL: 

Published: 1996-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi