| Project/Area Number |
08680866
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
TAKANASHI Yoshiaki Kyoto Prefectural University of Medicine, Medical school, Associate Professor, 医学部, 助教授 (40171459)
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| Co-Investigator(Kenkyū-buntansha) |
MAKINO Masahiro Kyoto Prefectural University of Medicine, Medical school, Associate Professor, 医学部, 助手 (80271162)
NARUSE Syouji Kyoto Prefectural University of Medicine, Medical school, Associate Professor, 医学部, 助教授 (50106407)
岩本 一秀 京都府立医科大学, 医学部, 助手 (70232709)
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1998: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1997: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1996: ¥300,000 (Direct Cost: ¥300,000)
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| Keywords | Nonivaseve brain imaging / Magnetoencephalography / Functional magnetic resonance imagining / Visual evoked magnetic field / Inversion problem / 格子点移動法 / 非侵襲的脳機能測定法 / 脳磁図(MEG) / 機能的核磁気共鳴法(fMRI) / 体性感覚誘発磁場 / 非侵襲的能機脳測定法 / 視覚誘発磁場反応 / レチノトピー |
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| Research Abstract |
ABSTRACT.In order to visualize the human retinotopy in vivo we compared the source location of P100m dipoles in visual evoked magnetic fields (VEFs) with the activated area obtained by functional magnetic resonance imaging (fMRI) with EPI method. Checkerboard reversal pattern stimulation was presented to the left and right hemifields, and to the upper and lower quadrant fields of five normal subjects. VEF were recorded using a 129-channel vector neuromagnetic imaging system (Shimadzu Co., SBI-l00). fMRI was obtained by a conventional 1.5T MRI scanner from the same subject using echo planar imaging sequence. In half-field stimulation, the source location of P100m was estimated on the contralateral calcarine sulcus. The location of equivalent current dipole (ECD) in lower quadrant stimuli was below calcarine sulcus. In fMRI, the activated area in half-field stimuli was situated in the lingual gyrus below the contralateral calcarine fissure. However, the activated areas in quadrant stimuli were situated around the posterior part of the contralateral lingual gyrus. Our results show that the locations of ECDs in pattern reversal VEFs roughly agree with the activated area in fMRI.The reliability of source localization of P100m must be reinforced by a fMRI study.
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