| Project/Area Number |
08680894
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
神経・脳内生理学
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| Research Institution | Showa University |
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Principal Investigator |
HOMMA Ikuo Showa University, School of Medicine, Professor, 医学部, 教授 (20057079)
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| Co-Investigator(Kenkyū-buntansha) |
KANAMARU Mitsuko Showa University, Shcool of Medicine, Assistant, 医学部, 助手 (40255716)
IWASE Michiko Showa University, Shcool of Medicine, Assistant, 医学部, 助手 (80119164)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1997: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1996: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | histaminergic neuron, / respiration, / preooptic area / anterior hypothalamus, / medulla oblongata, / microdialysis / 中枢ヒスタミンニューロン / 呼吸機能 / 後部視床下部 / 結節乳頭核 / 頚部交感神経 / 延髄吻側腹外側部 / 気管張力 |
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| Research Abstract |
Central histaminergic neurons locate in the tuberomammillary nucleus of the posterior hypothalamus, and project to all of the brain. Previous study revealed that the tuberomammillary mucleus sends the efferent pathways to the cervical sympathetic nerve, and that the histaminergic neurons involved in this pathway influences tracheal tension through the rostral ventrolateral medulla. The aim of the present study is to examine physiologically and neurochemically the effects of histaminergic neuron on the respiration. Rabbits were anesthetized, paralyzed, vagotomized, artificially ventilated and raised the body temperature. Respiratory frequency was increased with raising body temperature from 39^oC to 41^oC.This effect is prevented by administration of H_1 receptor antagonist, pyrilamine 1 mumol into the preoptic area/anteior hypothalamus, but not affected by cimetidine. 0.4 mumol into the same area. The respiratory frequency was not affected by administration of histamine (50 nmol) into the fourth ventricle, but increased by histamine i.c.v.after histamine H_1 receptor antagonist, pyrilamine i.c.v.and decreased by histamine after H_2 antagonist, cimetidine i.c.v.. The histamine release was increased in the rostral ventrolateral medulla, the solitary nucleus and the raphe magnus by raising body temperature. Results show that central histaminergic neuron affects on the respiration through hypothalamus and medulla oblongata, and that it seems to have a role of adaptation to the circumstances.
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