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Suppression of testicular function by chronic stress in macaque monkeys.

Research Project

Project/Area Number 08680907
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

SHIMIZU Keiko  Primate Research Institute Kyoto University Assistant Professor, 霊長類研究所, 助手 (90135616)

Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1997: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1996: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsJapanese monkey / Male / Stress / Testosterone / Cortisol / Testis / マカクザル / ACTH / CRH
Research Abstract

Five sexually mature, male Japanese monkeys (Macaca fuscata fuscata), at least 8 yrs old were used. They were housed in an each outdoor social group cage with some females at the Primate Research Institute, Kyoto University, Japan. After two weeks of blood sampling, they were isolated from a social group to an indoor air-conditioned individual cage in the mid breeding season. After two weeks these males were returned to their home cages. Blood samples were obtained following both the removal and the return two weeks later. Plasma concentrations of luteinizing hormone(LH), testosterone, cortisol, prolactin, and inhibin were determined by specific radioimmunoassays. Plasma concentrations of testosterone were significantly increased after the isolation, whereas cortisol levels were decreased. Following after return to their home cage, these changes were recovered. The absence of a stress response to separation in adult males is in contrast to the presence of a stress response observed in infants, juveniles, and adult females and possibly is due to the differences of environmental temperature.
In the next bleeding season, same monkeys were isolated from a social group to an outdoor individual cage. After two weeks isolation, they were returned to their home cages. Blood samples were obtained in the same manner. Plasma testosterone were significantly increased immediately after both isolation and return, but decreased within the isolation period. In contrast with the previous study, plasma cortisol were elevated immediately after both isolation and return. Plasma LH, prolactin, and inhibin were not changed before and after the isolation. These results showed that the isolation was influenced these males as a stressor. Furthermore, the return to the social group did induce a psychosocial stress response in the males and the degree of the stress.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] Shimizu, Keiko: "Suppression of ovarian function and successful contraception in macaque monkeys following a single injection of medroxyprogesterone acetate." Journal of Reproduction and Development.42(2). 147-151 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shimizu, K.: "Suppression of ovarian function and successfulJ.contraception in macaque monkeys following a single injection of medroxyprogesterone acetate." Reprod.Dev.42(2). 147-15 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Keiko Shimizu: "Suppression of ovarian function and successful contraception in macaque monkeys following single injection of medroxyprogesterone acetate" Journal of Reproduction and Development. 42(2). 147-155 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Joseph Soltis: "Sexual selection in Japanese macaques I:female mate choice or male sexual coercion?" Anim.Behav.54. 725-736 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Joseph Soltis: "Sexual selection in Japanese macaques II:female mate choice and male-male competition" Anim.Behav.54. 737-746 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Akio Mori: "Sexual maturation of female Japanese macaques under poor nutritional conditions and food-enhanced perineal swelling in the Koshima troop." International Journal of Primatology. 18(4). 553-579 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Keiko Shimizu: "Suppression of ovarian function and sucoessful contraception in macaque monkeys following single injection of medroxyprogesterone acetate" Journal of Reproduction and Development. 42(2). 147-155 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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