| Project/Area Number |
08680925
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
TSUBOI Yoichi Kyoto Univ.Dept of Oral Surg. Assistant Prof., 医学研究科, 助手 (60221420)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Kenichoro Kyoto Univ.Dept of Oral Surg.Associate Prof., 医学研究科, 助教授 (00174269)
EKTESSABI M Ali Kyoto Univ.Dept of Precision Eng.Associate Prof., 工学研究科, 助教授 (50232939)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1997: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1996: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | Titanium / Ion Beam Procedure / Metal Release / Biomaterials |
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| Research Abstract |
We have applied the engineering of semi-conductor technology such as ion beam procedure for the surface modification of titanium based biomaterials. These composite materials coated by TiO<@D22@>D2 and HAP using Ion beam assisted sputter depositioning (IBASD) method had a strong chemical and mechanical properties in virto. Animal experiments showed that these IBASD modified thin films on titanium substrate had a high compatibility both in soft tissue and hard tissue in vivo conditions. The results revealed as follows. 1.Soft tissue reaction : PIXE analysis showed that there was a limited titanium release from TiO2-surface-modified materials in rat abdominal walls in relation to a limited numbers of inflammatory cell migration along the modified surface implants. 2.Hard tissue reaction : The histomorphometric analysis showed that there was statistically higher bone contact in the cortical passage of IBASD-HAP specimens (70.2(]SY.+-。[)4.2) as compared with the control (41.6(]SY.+-。[)14.9, p<0.01). In conclusion, more bone was found adjacent the IBASD-HAP coated implants without any negative effects on bone healing.
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