| Project/Area Number |
08680930
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | KUMAMOTO UNIVERSITY |
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Principal Investigator |
SAKAKIDA Miciharu KUMAMOTO UNIVERSITY,SCHOOL OF MEDICINE,ASSISTANT PROFESSOR, 医学部・附属病院, 助手 (50170577)
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| Co-Investigator(Kenkyū-buntansha) |
SHIROTANI Tetsuya KUMAMOTO UNIVERSITY,SCHOOL OF MEDICINE,ASSISTANT PROFESSOR, 医学部・附属病院, 助手 (30274715)
SHICHIRI Motoaki KUMAMOTO UNIVERSITY,SCHOOL OF MEDICINE,PROFESSOR, 医学部, 教授 (00028515)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | closed-loop subcutaneous insulin infusion algorithm / wearable artificial endocrine pancreas / short-acting insulin analogue (Insulin Lispro) / regular insulin |
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| Research Abstract |
Considering the management and safety of the insulin delivery route when a wearable artificial endocrine pancreas is applied to ambulatory diabetic patients for long-term basis, we developed a subcutaneous insulin infusion algorithm by analyzing the dynamics of subcutaneously injected short-acting insulin analogue (Insulin Lispro) by a three-compartmental model. Principally, the insulin infusion algorithm was developed as a transfer function with the first order delay in both proportional and derivative actions to blood glucose concentrations. The parameters for this algorithm were calculated to simulate a physiological plasma insulin profile as possible.
By applying this algorithm with regular insulin, diabetic patients showed a 2-hr postprandial hyperglycemia and a delayd hyperinsulinemia, folowed by hypoglycemic episodes during 4 to 5 hr after oral glucose load, just as obervrd in computer simulation study. However using Insulin Lispro, a near-physiological glycemic control (postprandial blood glucose of 153.1(]SY.+-。[)8.3 mg/100 ml at 60 min, and 90.3(]SY.+-。[)7.1 mg/100 ml at 180 min, respectively) could be achieved without showing any delayd hyperinsulinemia nor hypoglycemia. Daily glycemic excursions were also controlled near-physiolosically and though the daily insulin requirement (731.7(]SY.+-。[)160.5 mU/kg/day) was slightly higher, but not significantly different from that with intravenous insulin infusion (622.3(]SY.+-。[)142.6 mU/kg/day).
These results indicate that the application of the subcutaneous insulin infusion algorithm with Insulin Lispro is feasible for long-term glycemic control with the wearable artificial endocrine pancreas in ambulatory diabetic patients.
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