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Endogenous signal-responsive drug release from bioactive bone cement

Research Project

Project/Area Number 08680946
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKobe Pharmaceutical Univesity

Principal Investigator

OTSUKA Makoto  Kobe Pharmaceutical University, Associate Professor, 薬学部, 助教授 (90160548)

Co-Investigator(Kenkyū-buntansha) SUGIYAMA Yuichi  University of Tokyo, Professor, 薬学部, 教授 (80090471)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1997: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1996: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsOsteoporosis / Drug delivery system / apatite / biomaterials / sustained drug release / atificial bone / intelligent materials / bone mineral density / 骨粗鬆症, / 薬物送達システム, / アパタイト, / バイオマテリアル, / 徐放化, / 人工骨, / インテリジェントマテリアル, / 除放化
Research Abstract

Osteoporotic fractures are observed more commonly among post-menopausal women, since bone mechanical strength is closely related to bone mineral density which reflects nutritional factors such as calcium and vitamin D.Since steroid hormones with estrogenic activity such as oestradiol and estron are considered to be related to the regulation of bone resorption and bone formation, bone remodeling after menopause becomes relatively inactive due to a decrease in the amount of hormone amount with the subsequent decrease in the mineral density of the bone. We designed a delivery system for several drugs using a biocompatible self-setting calcium phosphate cement which is transformed into hydroxyapatite in the body. The effect of plasma calcium levels on the oestradiol release from a self-setting apatite bone cement containing oestradiol in ovariectomized rats was investigated. The in-vitro release profiles from the cements in simulated body fluid containing 0.5 and 10mg/100mL calcium indicated that the oestradiol release rate decreased with increasing calcium concentration in dissolution media, suggesting that the in-vitro oestradiol release from apatite bone cement was dependent on the calcium concentration in the buffer. We applied this finding to the drug delivery system and reported that oestradiol release osteoporisi rats was greater than that observed in healthy rats after subcutaneous implantation of oestradiol-loaded cement, indicating that the in-vivo oestradiol release from apatite bone cement was dependent on plasma calcium levels.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] A.A.Baig, et al.: "Effect of Carbonate Content and Crystallinity on the Metastable Equilibirium Solubility Behavior of Carbonated Apatite," J.Colloid Inter.Sci.179. 608-617 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] C.Hamasnishi, et al.: "A Self-Setting TTCP-DCPD Apatite Cement of Release of Vancomycin" Applied Biomaterials. 33. 139-143 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Otsuka, et al.,: "Plasma Calcium Level-Responsive Oestradiol Release From Self-Setting Apatitic Bone Cement in Ovariectomized Rats." Pharm.Sci.2 (7). 321-323 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Otsuka, et al.: "Effect of Micropore Structure on Drug Release from Self-Setting Calcium Phosphate Cement Containing Anti Cancer Agent" Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems. 1996. 367-368 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Otuska, et al.: "Osteroporosis-Responsive Estradiol Release from Self-Seting Apatitic Bone Cement" Proceedings of the 23rd International Symposium on Controlled Release of Bioactive Matrials.23. 186-187 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Otsuka, et al.: "In Vitro and in vivo Indomethacin Release form Self-Setting Bioactive Bone Cement" Bioceramics. 9. 271-274 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.A.BAIG,et al.: "Effect of Carbonate Content and Crystallinity on the Metastable Equilibirium Solubility Behavior of Carbonated Apatite" J.Colloid Inter.Sci.179. 608-617 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] C.HAMANISHI,et al.: "A Self-Setting TTCP-DCPD Apatite Cement for Release of Vancomycin" Applied Biomaterials. 33. 139-143 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.OTSUKA,et al.: "Plasma Calcium Level-Responsive Oestradiol Release From Self-Setting Apatitic Bone Cement in Ovariectomized Rats" Pharm.Sci.2(7). 321-323 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.OTSUKA,et al.: "Effect of Micropore Structure on Drug Release frm Self-Setting Calcium Phosphate Cement Containing Anti-Cancer Agent" Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems. 1996. 367-368 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.OTSYKA,et al.: "Osteroporosis-Responsive Estradiol Release from Self-Seting Apatitic Bone Cement" Proceedings of the 23rd International Symposium on Controlled Release of Bioactive Matrials. 23. 186-187 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.OTSUKA,et al.: "In Vitro and in vivo Indomethacin Release from Self-Setting Bioactive Bone Cement" Bioceramics. 9. 271-274 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.A.Baig.et al.,: "Eefect of Carbonate Content and Crystallinity on the Metastable Equilibirium Solubility Behavior of Carbonated Apatite" J.Colloid Inter.Sci.,. 179,. 608-617 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] C.Hamasnishi.et al.,: "A Self-Setting TTCP-DCPD Apatite Cement for Release of Vancomycin," Applied Biomaterials,. 33,. 139-143 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Otsuka,et al.,: "Plasma Calcium Level-Responsive Oestradiol Release From Self-Setting Apatitic Bone Cement in Ovariectomized Rats," Pharm.Sci.,. 2(7). 321-323 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Otsuka,et al.,: "Effect of Micropore structure on Drug Release from Self-Setting Calcium Phosphate Cement Containing Anti-Cancer Agent," Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems,. 1996. 367-368 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Otsuka,et al.,: "Osteroporosis-Responsive Estradiol Release from Self-Seting Apatitic Bone Cement," Proceedings of the 23rd International Symposium on Controlled Release of Bioactive Matrials,. 23,. 186-187 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Otsuka,et al.,: "In Vitro and in vivo Indomethacin Release from Self-Setting Bioactive Bone Cement," .Bioceramics. 9,. 271-274 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] A.A.Baig,et al.: "Effect of Carbonate Content and Crystallinity on the Metastable Equilibirium Solubility Behavior of Carbonated Apatite." J.Colloid Inter.Sci.179. 608-617 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Z.Wang,et al.: "Calculation of Intercrystalline Solution Composition druing In Vitro Subsurface Lesion Formation in Dental Minerals." J.Pharm.Sci.85. 117-128 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] C.Hamasnishi,et al.: "A Self-Setting TTCP-DCPD Apatite Cement for Release of Vancomycin." Applied Biomaterials.33. 139-143 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Otsuka,et al.: "Plasma Calcium Level-Responsive Estradiol Release From Self-Setting Apatitic Bone Cement in Ovariectomized Rats." Pham.Sci.2. 321-323 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Otsuka,et al.: "Effect of Micropore Structure on Drug Release from Self-Setting Calcium Phosphate Cement Containing Anti-Cancer Agent." Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems.1996. 367-368 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Otsuka,et al.: "Osteoporosis-reponsive Estradiol Release From Selt-Setting Apatitic Bone Cement" Proceedings of the 23rd International Symposium on Controlled Release of Bioactive Matrials.23. 186-187 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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