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A Comparative Study between Masticatory Muscular Activity and Regional Brain Function during Gum Chewing as Measured using a Whole-body Positron Emission Tomography

Research Project

Project/Area Number 08835002
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 咀嚼
Research InstitutionTohoku University

Principal Investigator

ITOH Masatoshi  Tohoku University, Cyclotron RI Center, Division of Nuclear Medicine, Professor, サイクロトロンRIセンター, 教授 (00125501)

Co-Investigator(Kenkyū-buntansha) FUJIWARA Takehiko  Tohoku University, Cyclotron RI Center, Div.of Nuclear Medicine, Research Chief, サイクロトロンRIセンター, 助手 (70238632)
IWATA Ren  Tohoku University, Cyclotron RI Center, Div.of Radiochemistry, Senior Researcher, サイクロトロンRIセンター, 助教授 (60143038)
YAMADA Susumu  Tohoku University, Institute for Aging, Department of Functional Imaging, Senior, 加齢医学研究所, 助手 (70182532)
WATANABE Makoto  Tohoku University, School of Dental Medicine, Department of Geriatric Dental Med, 歯学部, 教授 (80091768)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1997: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsMastication / Muscular Activity / Brain Function / Positron Tomography / PET / Brain Imaging / Glucose Metabolism / Energy Metabolism
Research Abstract

The purpose of the study is to investigate the effects of mastication on whole-body activity using regional energy metabolism as a marker. A whole-body positron emission tomography (PET) was carried out using ^<15>O water as a tracer for regional cerebral blood flow (rCBF) in nine normal volunteers. The energy metabolism of masticatory and tongue muscles during chewing was also measured in another four subjects using ^<18>F-fluoro-D-deoxyglucose (FDG). Results : (1) Concerning muscular activity related to mastication, accumulation of FDG was the highest in the intrinsic tongue muscle. Heterogeneous regional uptake of FDG in the masticatory muscles, especially in the masseter muscles was found. FDG-PET could visualize relative workforce of the masticatory muscles at once. We conclude that the tongue plays a very important role in chewing. (2) The whole brain absolute rCBF increased 15% by gum-base chewing compared with the resting condition. Regional increases were most noted in the bilateral primary sensory-motor area. These results suggest that chewing and mastication stimulate brain and may be favorable for keeping our mental health.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (38 results)

All Other

All Publications (38 results)

  • [Publications] 佐藤 亨至, 伊藤 正敏, 他2名: "ポジトロンCTによる咀嚼時脳血流動態と咬合との関連。" 日本矯正歯科学会雑誌. 55・4. 300-310 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 伊藤 正敏, 長沢 治夫, 他1名: "Functional Mappingの臨床応用。PETによる脳機能マッピング" Neurological Surgery. 24・9. 663-783 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 藤本 敏彦, 伊藤 正敏, 他3名: "Whole-body metabolic map with positron emission tomography of a man agter running" Lancet. 348・9022. 266 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 渡部 浩司, 伊藤 正敏, 他6名: "Noninvasive quantification of rCBF using positron emission tomography." J Cereb Blood Flow Metab. 15・4. 311-319 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 長沢 治夫, 伊藤 正敏, 他5名: "PET study of cerebral glucose metabolisn and fluorodopa uptake in patients with corticobasal degeneration" J Neurol Sci. 139・4. 210-217 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 田代 学, 伊藤 正敏, 他五名: "Three-dimensional PET.An approach in psychology." J Int Soc Life Informat Sci. 14・2. 282-287 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 伊藤 正敏, 渡部 浩司, 他9名: "Quantification of brain function using PET" Myers R,Jones T.Academic Press,London, 443 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Singh LN,Higano S,Takahashi S,et al.: "Functional MR Imaging of cortical activation of the cerebral hemispheres during motor tasks." Am J Neuroradiol. 19. 275-280 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K Inoue, R Kawashima, K Satoh, S Kinomura, R Goto, M Koyama, M Sugiura, M Itoh, H Fukuda: "A PET Study of Pointing With Visual Feedback of Moving Hands" J.Neurophysiol. 79. 117-125 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K Inoue, R Kawashima, Ki Satoh, S Kinomura, R Goto, M Sugiura, M Itoh and H Fukuda.: "Activity in the parietal area during visuomotor learing with optical rotation" NeuroReport. 8. 3979-3983 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Fujiwara, T.Watanuki, S.Yamamoto, S.MIYAKE,M.Seo, S.Itoh M.et al.: "Performance evaluation of a large axial field-of-view PET scanner. SET-2400W" Annals of Nuclear Medicine 11. No.4. 307-313 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.M.Deloar, H.Watabe, T.Nakamura, Y.Narita, A.Yamadera, T.Fujiwara and M.Itoh: "Internal Dose Estimation Including the Nasal Cavity and Major Airway for Continuous Inhalation of C1502,1502 and C150 Using the Thermoluminescent Dosimeter Method" J Nucl Med. 38. 1603-1613 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Meguro K,Yamaguchi S,Itoh M,et al.: "Striatal dopamine metabolism correlated with frontotemporal glucose utilization in Alzhiemer's disease : A double-tracer PETS study." Neurology. 49. 941-5 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S Yamaguchi, K Meguro, M Itoh et al.: "Decreased cortical glucose metabolism correlates with hippocampal atrophy in Alzheimer's disease as shown by MRI and PET" J Neurol.Neurosurg Psychiat.62. No.6. 596-600 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Higuchi, M.Arai, H.Nakagawa, T.Higuchi, S.Muramatsu, T.Matsushita, S.Kosaka, Y.Itoh, M.Sasaki, H.: "Regional cerebral glucose utilization is modulated by the dosage of apoprotein E type 4 allele and alpha1-antichymotrypsin type A allele in Alzheimer's disease" Neuroreport. 8. 2639-43 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Itoh M,Miyazaki H,Tashiro M,Xiang X-Z,Higuchi M,Iwata R,Ido T.: "Functional analysis of the brain at rest studied by PET and EEG" J Intl Soc Life Info Sci. 15 (2). 282-292 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tashiro M,Kamada M,Itoh M,Kumano H,Kubota K,et al.: "Brain imaging of patients suffering from cancer" J Intl Soc Life Info Sci. 15 (2). 408-411

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Watabe H,Itoh M,Cunningham V,Lammertsma AA,Bloomfield P,et al.: "Noninvasive quantification of rCBF using positron emission tomography" J Cereb Blood Flow Metab. 15. 311-319 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tashiro M,Xiang X-Z,Okamura N,Ishizaki H,Miyazaki H,Ishii K,Itoh M.: "Three-dimensional PET : An approach in psychology" J Int Soc Life Informat Sci. 14 (2). 282-287 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Itho M,Miyazaki H,Takahashi Y.: "Imaging of mind using positron emission tomography" J Int Soc Life Informat Sci. 14 (1). 76-85 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Itho M,Watabe H,Miyake M,Hagisawa S,Fujiwara T,et al.: Noninvasive determination of arterial input of ^<15>O tracers, using a dual cutaneous beta-detector set above the radial artery Myers R (eds) Quantification of brain function using PET. Academic Press, London, 67-71 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Watabe H,Itoh M,Cunningham VJ,Lammertsma AA,Bloomfield PM,et al.: Noninvasive quantification of rCBF using positron emission tomography Myers R (eds) Quantification of brain function using PET. Academic Press, London, 191-195 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mejia MA,Itoh M,Watabe H,Fujiwara T,Nakamura T.: Quantiative noninvasive estimation of rCBF by using [150] water and PET Myers R (eds) Quantification of brain function using PET. Academic Press, London, 206-208 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 井上健太郎、 伊藤正敏他6名: "Activity in the parietal area during visuomotor learning with optical rotation" NeuroReport. 8・4. 3979-3983 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 藤原竹彦、 伊藤正敏他10名: "Performance evaluation of a large axial field-of-view PET scanner : SET-2400W" Annals of Nuclear Medicine. 11・4. 4307-313 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] H.M.Deloar, 伊藤正敏他6名: "Internal Dose Estimation Including the Nasal Cavity and Major Airway for Continuous Inhalation of C1502,1502 and C150 Using the Thermoluminescent Dosimeter Method" Journal of Nuclear Medicine. 38・4. 1603-1613 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 目黒謙一、 伊藤正敏他3名: "Striatal dopamine metabolism correlated with frontotemporal glucose utilization in Alzheimer's disease : A double-tracer PETS study" Neurology. 49・2. 941-945 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 山口智、 伊藤正敏他5名: "Decreased cortical glucose metabolism correlates with hippocampal atrophy in Alzheimer's disease as shown by MRI and PET" J Neurol.Neurosurg Psychiat. 62・6. 596-600 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 樋口真人、 伊藤正敏他7名: "Regional cerebral glucose utilization is modulated by the dosage of apoprotein E type 4 allele and α1-antichymotrypsin type A allele in Alzheimer's disease" Neuroreport. 8・6. 2639-2643 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 伊藤正敏、 宮崎浩他5名: "Functional analysis of the brain at rest studied by PET and EEG" J Intl Soc Life Info Sci. 15・2. 282-292 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Singh LN, 高橋昭喜: "Functional MR imaging of cortical activation of the cerebral hemispheres during motor tasks." American Journal of Neuroradiology. 19・1. 2113-2197 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 佐藤亨至、伊藤正敏他2名: "ポジトロンCTによる咀嚼時脳血流動態と咬合との関連。" 日本矯正歯科学会雑誌. 55・4. 300-310 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 伊藤正敏、長沢治夫他1名: "Functional Mappingの臨床応用。PETによる脳機能マッピング" Neurological Surgery. 24・9. 663-783 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 藤本夫敏彦,伊藤正敏他3名: "Whole-body metabolic map with positron emission tomography of a man after running" Lanet. 348・9022. 266 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 渡部浩司、伊藤正敏他6名: "Noninvasive quantification of rCBF using positron emission tomography." J、 Cereb Blood Flow Metab.15・4. 311-319 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 長沢治夫、伊藤正敏他5名: "PET study of cerebral glucose metabolism and fluorodopa uptake in patients with corticobasal degeneration" J、 Neurol Sci.1994・4. 210-217 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 田代学、伊藤正敏他五名: "Three-dimensional PET : An approach in psychology." J、 Int Soc、 Life Informat Sci.14・2. 282-287 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 伊藤正敏、渡部浩司他9名: "Quantification of brain functon using PET" Myers R, Jones T. Academic Press, London, 443 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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