| Project/Area Number |
08835002
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
咀嚼
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
ITOH Masatoshi Tohoku University, Cyclotron RI Center, Division of Nuclear Medicine, Professor, サイクロトロンRIセンター, 教授 (00125501)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Takehiko Tohoku University, Cyclotron RI Center, Div.of Nuclear Medicine, Research Chief, サイクロトロンRIセンター, 助手 (70238632)
IWATA Ren Tohoku University, Cyclotron RI Center, Div.of Radiochemistry, Senior Researcher, サイクロトロンRIセンター, 助教授 (60143038)
YAMADA Susumu Tohoku University, Institute for Aging, Department of Functional Imaging, Senior, 加齢医学研究所, 助手 (70182532)
WATANABE Makoto Tohoku University, School of Dental Medicine, Department of Geriatric Dental Med, 歯学部, 教授 (80091768)
|
|---|
| Project Period (FY) |
1996 – 1997
|
| Project Status |
Completed (Fiscal Year 1997)
|
| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1997: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
|
|---|
| Keywords | Mastication / Muscular Activity / Brain Function / Positron Tomography / PET / Brain Imaging / Glucose Metabolism / Energy Metabolism |
|---|
| Research Abstract |
The purpose of the study is to investigate the effects of mastication on whole-body activity using regional energy metabolism as a marker. A whole-body positron emission tomography (PET) was carried out using ^<15>O water as a tracer for regional cerebral blood flow (rCBF) in nine normal volunteers. The energy metabolism of masticatory and tongue muscles during chewing was also measured in another four subjects using ^<18>F-fluoro-D-deoxyglucose (FDG). Results : (1) Concerning muscular activity related to mastication, accumulation of FDG was the highest in the intrinsic tongue muscle. Heterogeneous regional uptake of FDG in the masticatory muscles, especially in the masseter muscles was found. FDG-PET could visualize relative workforce of the masticatory muscles at once. We conclude that the tongue plays a very important role in chewing. (2) The whole brain absolute rCBF increased 15% by gum-base chewing compared with the resting condition. Regional increases were most noted in the bilateral primary sensory-motor area. These results suggest that chewing and mastication stimulate brain and may be favorable for keeping our mental health.
|
