| Project/Area Number |
08835015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
咀嚼
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| Research Institution | Nagasaki University |
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Principal Investigator |
HOTOKEZAKA Yuka (1997) Nagasaki University, School of Dentistry, Instructor, 歯学部, 助手 (10244089)
山田 美穂 (1996) 長崎大学, 歯学部附属病院, 助手 (80200749)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Takashi Nagasaki University, School of Dentistry, Prof., 歯学部, 教授 (30172406)
SATO Hironobu Nagasaki University, School of Dentistry, Assoc.Prof., 歯学部, 助教授 (00145955)
佛坂 由可 長崎大学, 歯学部, 助手 (10244089)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | mandible / Bone mineral density / QCT |
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| Research Abstract |
We conducted volunteer studies to assess age-related changes of the mandibular condyle bone mineral density (BMD) and its correlation to the spinal BMD.Quantitative computed tomography was performed on the condyles and spines (L1-3) of 210 healthy volunteers (114 men and 96 women ; aged 5 to 85 years). A separate study was performed on 73 young student subjects (39 men and 34 women, aged 23 to 25 years). The mandibular condyle BMDshowed age-related changes similar to those of the spinal BMD.However, when expressed by T-score, the age-related decrement rates of the mandibular condyle BMD in men and women were lesser in extent compared with those of the spine BMD.Correlations in BMD between the mandibular condyle and spine were high in women (r = 0.78, p<0.0001), but moderate in men (r= 0.58, p< 0.0001). Gender-related difference was more dramatic when assessed in the young student group ; the mandibular condyle and spinal BMDs were highly correlated in women (r=0.82, p<0.0001), but no correlation was found in men (r=0.22). Taken together, these results showed that the mandibular condyle BMD decreased with age in a similar fashion to the lumbar spine BMD,suggesting the same regulatory mechanisms as in the spinal BMD.However, aside from the lumbar spine BMD, additonal undefined factor (s) may be involved in maintaining the mandibular BMD.
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