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Biochemical Properties of Peptides Induced by Abnormal Occulusion

Research Project

Project/Area Number 08835024
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 咀嚼
Research InstitutionFukuoka Dental College

Principal Investigator

ABE Kimio  Fukuoka Dental College, Prof.Dos, Ph.D.Dept.Oral Biochem., 歯学部, 教授 (70076016)

Co-Investigator(Kenkyū-buntansha) ISHIBASHI Kazunari  Accistant.Ph.D.Fukuoka Dental College, Dept.of Oral Biochemistry, 歯学部, 助手 (50122768)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsAbnormal occulusion / Peptide / Saliva / Rat and human's / HPLC / Amino acid sequence / Primary structure / Glix-rich protein / Glix-rich protein
Research Abstract

This study was designed to determine whether some proteins were affected by the abnormal occulusion and thereafter induced various peptides. Different dental treatment such as feeding with dental caries diet (D-2OOO), tooth extraction and orthodontic treatment was carried out in this study. In humans and rats, some proteins of parotid and submandibular salivas were affected by thee abnormal occulusion, but proline- and histidine-rich, and glutamine/glutamic acid-rich proteins were only degraded into various peptides. We do not know why such discrimination was occurred by the abnormal occulusion. Amino acid sequences and concentrations of induced peptides (P19, 20, 21, 24, 28 and 31, which we termed by HPLC) were elucidated and determined quantitatively after various treatments.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] 石橋 一成、阿部 公生: "ヒスタミンの種類と生物作用に関する研究の最近の動向" 福岡歯科大学学会雑誌. 23・1. 1-12 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 西浦 利博、阿部 公生: "ラット唾液のシステインプロテアーゼインヒビター(ラットシスタチン S)" 福岡歯科大学学会雑誌. 23・3. 321-338 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 椛島 俊作ほか: "〓蝕誘発性高シュークロス食によるラット顎下腺唾液ペプチドの分泌促進" 歯科基礎医学会雑誌. 38・6. 611-619 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Abe,K.et al.: "The effects of 5-hydroxydopamine on salivary flow ‐‐‐" Experimental Physiology. 81. 645-653 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 藤江 徹,高潮ほか: "矯正力に対する生体反応" 歯科基礎医学会雑誌. 30(補冊). 481 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Abe, K., Okina, A., Yano, T., Gao, C., Ohmori, H., Ishibashi, K., Nishiura, T.andLetic-Gavrilovic, A.: "Abnormally high levels of cystatin S in submandibular glands, saliva and gingiva of plaqueresistant rats." J.Dent.Res.77(11). 1913-1919 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamada, K., Letic-Gavrilovic, A., Mori, M., Nishiura, T., Nagata, H.and Abe, K.: "Immunohistochemical and quantitative analysis of cystatin S in the submandibular and sublingual glands of rats" Stom.Glas.S.45. 19-25 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tashiro.M., Letic-Gavrilovic, A., Nakamura, H., Ohkuma, K., Egashira, Y., Ohmori, H., Nagata, H., Harada, M.and Abe, K.: "The effects of 6-hydroxydopamine and potential antagonists on flow rates and protein secretion by rat submandibular glands." Stom.Glas.S.44. 131-137 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Moroi, R., Yamaza, T., Nishiura, T., Nishimura, Y., Terada, Y., Abe, K., Himeno, M.and Tanaka, T.: "Immunocytochemical study of cathepsin L and rat salivary cystatin-3 in rat osteoclasts treated with E-64 in vivo." Archs Oral Biol.42(4). 305-315 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Letic-Gavrilovic Anka and Abe Kimio: Morphology and function of the salivary glands and saliva.CIP-katalogizacijia u publikaciji, Narodna biblioteka Srbije, Beograd, 1-360 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 石橋 一成、阿部 公生: "ヒスタチンの種類と生物作用に関する研究の最近の動向" 福岡歯科大学学会雑誌. 23・1. 1-12 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 西浦 利博、阿部 公生: "ラット唾液のシステインプロテアーゼインヒビター(ラットシスタチン S)" 福岡歯科大学学会雑誌. 23・3. 321-338 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 椛島 俊作ほか: "齲触誘発性高シュークロス食によるラット顎下腺唾液ペプチドの分泌促進" 歯科基礎医学会雑誌. 38・6. 611-619 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Abe,K.et al.: "The effects of 5-hydroxydopamine on salivary flow ‐‐‐‐‐" Experimental Physiology. 81. 645-653 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 藤江 徹, 高潮ほか: "矯正力に対する生体反応" 歯科基礎医学会雑誌. 30(補冊). 481 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Abe,K.,Itoh,T.,Tashiro,M.et al.: "The effects of 5-hydroxydopamine on salivary flow rates and protein secretion by the submandibular-----" Experimental Physiology. 81. 645-653 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 石橋一成、阿部公生: "ヒスタチンの種類と生物作用に関する研究の最近の動向" 福岡歯大誌. 23・1. 1-21 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 西浦利博、阿部公生: "ラット唾液のシステインプロテアーゼインヒビター" 福岡歯大誌. 23・3. 321-338 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 椛島俊作ほか: "齲蝕誘発性高シュークロス食によるラット顎下腺唾液ペプチドの分泌促進" 歯基礎誌. 38・6. 611-619 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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